FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3165862178> ?p ?o ?g. }

• W3165862178 endingPage "545" @default.
• W3165862178 startingPage "545" @default.
• W3165862178 abstract "Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of neonatal sepsis and meningitis in infants. Limitations of prenatal GBS screening and intrapartum antibiotic prophylaxis render developing GBS vaccines a high priority. In this study, we developed an enzyme-linked immunosorbent assay (ELISA) for the practical and large-scale evaluation of GBS capsular polysaccharide (PS) vaccine immunogenicity against three main serotypes, Ia, III, and V. GBS-ELISA was developed and subsequently validated using a standardized curve-fitting four-parameter logistic method. Specificity was measured using adsorption of serum with homologous and heterologous PS. Homologous adsorption showed a ≥75% inhibition of all three serotypes, whereas with heterologous PS, IgG GBS-ELISA inhibited only ≤25% of serotypes III and V. However, with serotype Ia, IgG antibody levels decreased by >50%, even after adsorption with heterologous PS (III or V). In comparison, the inhibition opsonophagocytic killing assay (OPA) of serotypes Ia GBS exhibited a reduction in opsonophagocytic activity of only 20% and 1.1% for serotypes III and V GBS, respectively. The precision of the GBS-ELISA was assessed in five independent experiments using four serum samples. The coefficient of variation was <5% for all three serotypes. This standardized GBS-ELISA would be useful for GBS vaccine development and its evaluation." @default.
• W3165862178 created "2021-06-07" @default.
• W3165862178 creator A5009082444 @default.
• W3165862178 creator A5013371090 @default.
• W3165862178 creator A5035385618 @default.
• W3165862178 creator A5038612839 @default.
• W3165862178 creator A5048122883 @default.
• W3165862178 creator A5056005181 @default.
• W3165862178 creator A5058540147 @default.
• W3165862178 creator A5068492828 @default.
• W3165862178 creator A5081947809 @default.
• W3165862178 creator A5091370008 @default.
• W3165862178 date "2021-05-21" @default.
• W3165862178 modified "2023-10-01" @default.
• W3165862178 title "Development and Validation of Enzyme-Linked Immunosorbent Assay for Group B Streptococcal Polysaccharide Vaccine" @default.
• W3165862178 cites W1536299500 @default.
• W3165862178 cites W1589482850 @default.
• W3165862178 cites W1815119967 @default.
• W3165862178 cites W1894280218 @default.
• W3165862178 cites W2023284037 @default.
• W3165862178 cites W2096093282 @default.
• W3165862178 cites W2119888547 @default.
• W3165862178 cites W2129655108 @default.
• W3165862178 cites W2136755398 @default.
• W3165862178 cites W2342773131 @default.
• W3165862178 cites W2462488121 @default.
• W3165862178 cites W2561215256 @default.
• W3165862178 cites W2571306756 @default.
• W3165862178 cites W2759912437 @default.
• W3165862178 cites W2768050546 @default.
• W3165862178 cites W2870582212 @default.
• W3165862178 cites W2900629010 @default.
• W3165862178 cites W2907953173 @default.
• W3165862178 cites W2941444953 @default.
• W3165862178 cites W2964921937 @default.
• W3165862178 cites W2988206860 @default.
• W3165862178 cites W2999076846 @default.
• W3165862178 cites W3081894944 @default.
• W3165862178 cites W3082594120 @default.
• W3165862178 cites W3082776820 @default.
• W3165862178 doi "https://doi.org/10.3390/vaccines9060545" @default.
• W3165862178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8224333" @default.
• W3165862178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34064299" @default.
• W3165862178 hasPublicationYear "2021" @default.
• W3165862178 type Work @default.
• W3165862178 sameAs 3165862178 @default.
• W3165862178 citedByCount "1" @default.
• W3165862178 countsByYear W31658621782023 @default.
• W3165862178 crossrefType "journal-article" @default.
• W3165862178 hasAuthorship W3165862178A5009082444 @default.
• W3165862178 hasAuthorship W3165862178A5013371090 @default.
• W3165862178 hasAuthorship W3165862178A5035385618 @default.
• W3165862178 hasAuthorship W3165862178A5038612839 @default.
• W3165862178 hasAuthorship W3165862178A5048122883 @default.
• W3165862178 hasAuthorship W3165862178A5056005181 @default.
• W3165862178 hasAuthorship W3165862178A5058540147 @default.
• W3165862178 hasAuthorship W3165862178A5068492828 @default.
• W3165862178 hasAuthorship W3165862178A5081947809 @default.
• W3165862178 hasAuthorship W3165862178A5091370008 @default.
• W3165862178 hasBestOaLocation W31658621781 @default.
• W3165862178 hasConcept C10389963 @default.
• W3165862178 hasConcept C104317684 @default.
• W3165862178 hasConcept C126322002 @default.
• W3165862178 hasConcept C159047783 @default.
• W3165862178 hasConcept C159654299 @default.
• W3165862178 hasConcept C185592680 @default.
• W3165862178 hasConcept C203014093 @default.
• W3165862178 hasConcept C2777785397 @default.
• W3165862178 hasConcept C2777860557 @default.
• W3165862178 hasConcept C2778276568 @default.
• W3165862178 hasConcept C2780115692 @default.
• W3165862178 hasConcept C2780868878 @default.
• W3165862178 hasConcept C523546767 @default.
• W3165862178 hasConcept C54355233 @default.
• W3165862178 hasConcept C55493867 @default.
• W3165862178 hasConcept C71924100 @default.
• W3165862178 hasConcept C86803240 @default.
• W3165862178 hasConcept C89423630 @default.
• W3165862178 hasConceptScore W3165862178C10389963 @default.
• W3165862178 hasConceptScore W3165862178C104317684 @default.
• W3165862178 hasConceptScore W3165862178C126322002 @default.
• W3165862178 hasConceptScore W3165862178C159047783 @default.
• W3165862178 hasConceptScore W3165862178C159654299 @default.
• W3165862178 hasConceptScore W3165862178C185592680 @default.
• W3165862178 hasConceptScore W3165862178C203014093 @default.
• W3165862178 hasConceptScore W3165862178C2777785397 @default.
• W3165862178 hasConceptScore W3165862178C2777860557 @default.
• W3165862178 hasConceptScore W3165862178C2778276568 @default.
• W3165862178 hasConceptScore W3165862178C2780115692 @default.
• W3165862178 hasConceptScore W3165862178C2780868878 @default.
• W3165862178 hasConceptScore W3165862178C523546767 @default.
• W3165862178 hasConceptScore W3165862178C54355233 @default.
• W3165862178 hasConceptScore W3165862178C55493867 @default.
• W3165862178 hasConceptScore W3165862178C71924100 @default.
• W3165862178 hasConceptScore W3165862178C86803240 @default.
• W3165862178 hasConceptScore W3165862178C89423630 @default.
• W3165862178 hasIssue "6" @default.
• W3165862178 hasLocation W31658621781 @default.

• next