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- W3166000047 abstract "Abstract We show that the zebrafish maternal-effect mutation too much information ( tmi ) corresponds to zebrafish prc1-like ( prc1l ), which encodes a member of the MAP65/Ase1/PRC1family of microtubule-associated proteins. Embryos from tmi/prc1l homozygous mutant mothers display cytokinesis defects in meiotic and mitotic divisions in the early embryo, indicating that tmi/prc1l has a role in midbody formation during cell division at the egg-to-embryo transition. Unexpectedly, maternal tmi/prc1l function is also essential for the reorganization of vegetal pole microtubules required for embryonic axis induction. While Prc1 is widely regarded to crosslink microtubules in an antiparallel conformation, our studies provide evidence for an additional function of Prc1 in the bundling of parallel microtubules in the vegetal cortex of the early embryo during cortical rotation and prior to mitotic cycling. These findings highlight common yet distinct aspects of microtubule reorganization that occur during the egg-to-embryo transition, driven by maternal product for the midbody component Prc1l and required for embryonic cell division and pattern formation." @default.
- W3166000047 created "2021-06-22" @default.
- W3166000047 creator A5009189724 @default.
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- W3166000047 creator A5082674382 @default.
- W3166000047 creator A5085719085 @default.
- W3166000047 date "2021-06-11" @default.
- W3166000047 modified "2023-09-26" @default.
- W3166000047 title "A midbody component homolog, <i>too much information/prc1-like</i>, is required for microtubule reorganization during both cytokinesis and axis induction in the early zebrafish embryo" @default.
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- W3166000047 doi "https://doi.org/10.1101/2021.06.10.447958" @default.
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