FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166016144> ?p ?o ?g. }

• W3166016144 abstract "Several classes of antibiotics have reduced the mortality caused by infectious diseases; however, orally administered antibiotics alter the composition of gut microbiota, leading to dysbiosis-related disease. Therefore, in this study, we used 16S rRNA gene sequencing- and metabolomics-based approaches to investigate the effects of oral vancomycin on gut bacterial microbiota and the metabolome in biospecimens collected from healthy men. Samples collected from 11 healthy men were analyzed using 16S rRNA gene sequencing and metabolomics. 16S rRNA gene sequencing was performed to analyze the gut bacterial microbiota, and GC-TOFMS-based untargeted metabolomics was performed to analyze fecal, urine, and plasma metabolomics. Spearman’s rank correlation was utilized to explore the associations between gut bacterial microbiota and metabolome. Fecal 16S rRNA gene sequencing analysis showed decreased relative abundance of genera belonging to the phyla Bacteroidetes and Firmicutes, and increased relative abundance of genera of the phyla Proteobacteria and Fusobacteria. Fecal metabolomics analysis showed that levels of uracil, L-aspartic acid, lithocholic acid, and deoxycholic acid were significantly higher at baseline, whereas that of dihydrouracil was significantly higher after vancomycin administration. No significant metabolic markers were selected from urine and plasma metabolomics analysis. This study demonstrates that oral vancomycin administration induces alterations in gut bacterial microbiota and metabolome. Correlation analysis between our two datasets shows that alteration of the gut bacterial microbiota, induced by oral vancomycin, potentially affected the systemic activity of dihydropyrimidine dehydrogenase. This correlation should be further examined in future studies to define the effects of gut bacterial microbiota on drug-metabolizing enzymes, thereby contributing to the development of personalized therapy." @default.
• W3166016144 created "2021-06-22" @default.
• W3166016144 creator A5005301507 @default.
• W3166016144 creator A5022675590 @default.
• W3166016144 creator A5065271933 @default.
• W3166016144 creator A5074532898 @default.
• W3166016144 creator A5088839759 @default.
• W3166016144 creator A5091770295 @default.
• W3166016144 date "2021-05-27" @default.
• W3166016144 modified "2023-10-18" @default.
• W3166016144 title "Assessment of Oral Vancomycin-Induced Alterations in Gut Bacterial Microbiota and Metabolome of Healthy Men" @default.
• W3166016144 cites W190540197 @default.
• W3166016144 cites W1980588823 @default.
• W3166016144 cites W1980914602 @default.
• W3166016144 cites W1992174684 @default.
• W3166016144 cites W2003099302 @default.
• W3166016144 cites W2010427019 @default.
• W3166016144 cites W2012490955 @default.
• W3166016144 cites W2015567271 @default.
• W3166016144 cites W2018274907 @default.
• W3166016144 cites W2034638097 @default.
• W3166016144 cites W2035378093 @default.
• W3166016144 cites W2045869506 @default.
• W3166016144 cites W2055043387 @default.
• W3166016144 cites W2055568666 @default.
• W3166016144 cites W2061156796 @default.
• W3166016144 cites W2061543580 @default.
• W3166016144 cites W2062222093 @default.
• W3166016144 cites W2071273298 @default.
• W3166016144 cites W2085646040 @default.
• W3166016144 cites W2091330822 @default.
• W3166016144 cites W2093413494 @default.
• W3166016144 cites W2093500216 @default.
• W3166016144 cites W2100637729 @default.
• W3166016144 cites W2109976115 @default.
• W3166016144 cites W2110300022 @default.
• W3166016144 cites W2111188921 @default.
• W3166016144 cites W2114766231 @default.
• W3166016144 cites W2131848047 @default.
• W3166016144 cites W2134897177 @default.
• W3166016144 cites W2135959117 @default.
• W3166016144 cites W2139090295 @default.
• W3166016144 cites W2157107905 @default.
• W3166016144 cites W2167062509 @default.
• W3166016144 cites W2168716870 @default.
• W3166016144 cites W2295182096 @default.
• W3166016144 cites W2341031032 @default.
• W3166016144 cites W2343175653 @default.
• W3166016144 cites W2477430876 @default.
• W3166016144 cites W2499588178 @default.
• W3166016144 cites W2517182458 @default.
• W3166016144 cites W2529282553 @default.
• W3166016144 cites W2614426869 @default.
• W3166016144 cites W2617940752 @default.
• W3166016144 cites W2716620671 @default.
• W3166016144 cites W2767521922 @default.
• W3166016144 cites W2771045365 @default.
• W3166016144 cites W2790569372 @default.
• W3166016144 cites W2800454479 @default.
• W3166016144 cites W2890582054 @default.
• W3166016144 cites W2893759281 @default.
• W3166016144 cites W2899120957 @default.
• W3166016144 cites W2945204225 @default.
• W3166016144 cites W2951912016 @default.
• W3166016144 cites W2974361058 @default.
• W3166016144 cites W2999175750 @default.
• W3166016144 cites W3005732162 @default.
• W3166016144 cites W3030441098 @default.
• W3166016144 cites W3106333843 @default.
• W3166016144 cites W4211193962 @default.
• W3166016144 cites W4233197966 @default.
• W3166016144 cites W4247001379 @default.
• W3166016144 cites W4294326454 @default.
• W3166016144 doi "https://doi.org/10.3389/fcimb.2021.629438" @default.
• W3166016144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8190408" @default.
• W3166016144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34123865" @default.
• W3166016144 hasPublicationYear "2021" @default.
• W3166016144 type Work @default.
• W3166016144 sameAs 3166016144 @default.
• W3166016144 citedByCount "7" @default.
• W3166016144 countsByYear W31660161442022 @default.
• W3166016144 countsByYear W31660161442023 @default.
• W3166016144 crossrefType "journal-article" @default.
• W3166016144 hasAuthorship W3166016144A5005301507 @default.
• W3166016144 hasAuthorship W3166016144A5022675590 @default.
• W3166016144 hasAuthorship W3166016144A5065271933 @default.
• W3166016144 hasAuthorship W3166016144A5074532898 @default.
• W3166016144 hasAuthorship W3166016144A5088839759 @default.
• W3166016144 hasAuthorship W3166016144A5091770295 @default.
• W3166016144 hasBestOaLocation W31660161441 @default.
• W3166016144 hasConcept C135870905 @default.
• W3166016144 hasConcept C203014093 @default.
• W3166016144 hasConcept C21565614 @default.
• W3166016144 hasConcept C2777165150 @default.
• W3166016144 hasConcept C2777695942 @default.
• W3166016144 hasConcept C2779676784 @default.
• W3166016144 hasConcept C2779825944 @default.
• W3166016144 hasConcept C42062724 @default.
• W3166016144 hasConcept C523546767 @default.
• W3166016144 hasConcept C539455810 @default.

• next