Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166019870> ?p ?o ?g. }
- W3166019870 endingPage "1712" @default.
- W3166019870 startingPage "1701" @default.
- W3166019870 abstract "Haloquinones (XQs) are a group of carcinogenic intermediates of the haloaromatic environmental pollutants and newly identified chlorination disinfection byproducts (DBPs) in drinking water. The highly reactive hydroxyl radicals/alkoxyl radicals and quinone enoxy/ketoxy radicals were found to arise in XQs and H2O2 or organic hydroperoxides system, independent of transition-metal ions. However, it was not clear whether these haloquinoid carcinogens and hydroperoxides can cause oxidative DNA damage and modifications, and if so, what are the underlying molecular mechanisms. We found that 8-oxodeoxyguanosine (8-oxodG), DNA strand breaks, and three methyl oxidation products could arise when DNA was treated with tetrachloro-1,4-benzoquinone and H2O2 via a metal-independent and intercalation-enhanced oxidation mechanism. Similar effects were observed with other XQs, which are generally more efficient than the typical Fenton system. We further extended our studies from isolated DNA to genomic DNA in living cells. We also found that potent oxidation of DNA to the more mutagenic imidazolone dIz could be induced by XQs and organic hydroperoxides such as t-butylhydroperoxide or the physiologically relevant hydroperoxide 13S-hydroperoxy-9Z,11E-octadecadienoic acid via an unprecedented quinone-enoxy radical-mediated mechanism. These findings should provide new perspectives to explain the potential genotoxicity, mutagenesis, and carcinogenicity for the ubiquitous haloquinoid carcinogenic intermediates and DBPs." @default.
- W3166019870 created "2021-06-22" @default.
- W3166019870 creator A5010459854 @default.
- W3166019870 creator A5023333681 @default.
- W3166019870 creator A5044549205 @default.
- W3166019870 creator A5058532575 @default.
- W3166019870 creator A5091688285 @default.
- W3166019870 date "2021-06-18" @default.
- W3166019870 modified "2023-10-17" @default.
- W3166019870 title "Mechanistic Study on Oxidative DNA Damage and Modifications by Haloquinoid Carcinogenic Intermediates and Disinfection Byproducts" @default.
- W3166019870 cites W1489844805 @default.
- W3166019870 cites W1492600479 @default.
- W3166019870 cites W1566956508 @default.
- W3166019870 cites W165436564 @default.
- W3166019870 cites W1963656281 @default.
- W3166019870 cites W1963677661 @default.
- W3166019870 cites W1963712961 @default.
- W3166019870 cites W1965431138 @default.
- W3166019870 cites W1972925686 @default.
- W3166019870 cites W1974747095 @default.
- W3166019870 cites W1975111679 @default.
- W3166019870 cites W1977284972 @default.
- W3166019870 cites W1978788346 @default.
- W3166019870 cites W1980406629 @default.
- W3166019870 cites W1981463058 @default.
- W3166019870 cites W1986216535 @default.
- W3166019870 cites W1990436129 @default.
- W3166019870 cites W1990995854 @default.
- W3166019870 cites W1991402805 @default.
- W3166019870 cites W1994048261 @default.
- W3166019870 cites W1994218094 @default.
- W3166019870 cites W1997453048 @default.
- W3166019870 cites W1997678698 @default.
- W3166019870 cites W2001728345 @default.
- W3166019870 cites W2002543880 @default.
- W3166019870 cites W2004372709 @default.
- W3166019870 cites W2005645371 @default.
- W3166019870 cites W2011970030 @default.
- W3166019870 cites W2014496233 @default.
- W3166019870 cites W2015309343 @default.
- W3166019870 cites W2016279068 @default.
- W3166019870 cites W2016429792 @default.
- W3166019870 cites W2024568462 @default.
- W3166019870 cites W2024824638 @default.
- W3166019870 cites W2024849484 @default.
- W3166019870 cites W2025095151 @default.
- W3166019870 cites W2026591289 @default.
- W3166019870 cites W2026643562 @default.
- W3166019870 cites W2027310628 @default.
- W3166019870 cites W2027973177 @default.
- W3166019870 cites W2029084438 @default.
- W3166019870 cites W2029398242 @default.
- W3166019870 cites W2030838466 @default.
- W3166019870 cites W2031669135 @default.
- W3166019870 cites W2035426198 @default.
- W3166019870 cites W2035565332 @default.
- W3166019870 cites W2038449573 @default.
- W3166019870 cites W2038976515 @default.
- W3166019870 cites W2044272924 @default.
- W3166019870 cites W2047840739 @default.
- W3166019870 cites W2051159467 @default.
- W3166019870 cites W2052323419 @default.
- W3166019870 cites W2053873233 @default.
- W3166019870 cites W2054752346 @default.
- W3166019870 cites W2060245901 @default.
- W3166019870 cites W2065127825 @default.
- W3166019870 cites W2065532262 @default.
- W3166019870 cites W2066756161 @default.
- W3166019870 cites W2069932077 @default.
- W3166019870 cites W2071213636 @default.
- W3166019870 cites W2077450957 @default.
- W3166019870 cites W2081444345 @default.
- W3166019870 cites W2081767706 @default.
- W3166019870 cites W2081868798 @default.
- W3166019870 cites W2087276593 @default.
- W3166019870 cites W2089304463 @default.
- W3166019870 cites W2095358649 @default.
- W3166019870 cites W2101173364 @default.
- W3166019870 cites W2108664872 @default.
- W3166019870 cites W2116346328 @default.
- W3166019870 cites W2116776396 @default.
- W3166019870 cites W2119612457 @default.
- W3166019870 cites W2131860315 @default.
- W3166019870 cites W2132023404 @default.
- W3166019870 cites W2135445369 @default.
- W3166019870 cites W2139885239 @default.
- W3166019870 cites W2140291328 @default.
- W3166019870 cites W2147742582 @default.
- W3166019870 cites W2148357975 @default.
- W3166019870 cites W2149254097 @default.
- W3166019870 cites W2149343603 @default.
- W3166019870 cites W2151824008 @default.
- W3166019870 cites W2154765758 @default.
- W3166019870 cites W2156386262 @default.
- W3166019870 cites W2163293903 @default.
- W3166019870 cites W2252583923 @default.
- W3166019870 cites W2319549623 @default.
- W3166019870 cites W2322281855 @default.