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- W3166039206 abstract "Abstract Aging is a multifaceted process of accumulation of damages and waste in cells and tissues; age-related changes in mitochondria and in respiratory metabolism have been in the focus of aging research for decades. Here we investigated age-related changes in respiration rates, lactate/pyruvate ratio, a commonly used proxy for NAD+/NADH balance, and mitochondrial membrane potential in 4 genotypes of an emerging model organism for aging research, a cyclic parthenogen Daphnia magna . We show that total body weight-adjusted respiration rate decreases with age, although this decrease is small in magnitude and not observed in anaesthetized animals, thus likely to be accounted for by decrease in locomotion and feeding activity. Lactate/pyruvate ratio and mitochondrial membrane potential (Ψ mt ) showed no age-related changes, with a possible exception of Ψ mt measured in the optical lobe and in epipodites (excretory organs) in which Ψ mt showed a maximum at middle age. We conclude that actuarial senescence in Daphnia is not caused by a decline in respiratory metabolism and discuss possible mechanisms of maintaining mitochondrial healthspan throughout the lifespan." @default.
- W3166039206 created "2021-06-22" @default.
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- W3166039206 date "2021-06-07" @default.
- W3166039206 modified "2023-10-15" @default.
- W3166039206 title "Lack of Age-related Respiratory Changes in Daphnia" @default.
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- W3166039206 doi "https://doi.org/10.1101/2021.06.05.447222" @default.
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