Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166064327> ?p ?o ?g. }
- W3166064327 abstract "Dysregulation of ketone metabolism has been reported in various types of cancer. In order to find out its role in acute myeloid leukemia (AML) pathogenesis, we first analyzed the expression levels of 10 key genes involved in ketone metabolism in AML blasts and CD34 + hematopoietic stem cells (HSCs) from healthy donors. We found that the expression level of BDH1 was significantly lower in AML than in normal HSCs. The downregulation of BDH1 gene expression in AML cell lines as compared with normal HSCs was further confirmed with real-time RT-PCR. Analysis of TCGA and other database revealed that the downregulation of BDH1 was associated with worse prognosis in AML patients. In addition, we showed that overexpression of BDH1 inhibited the viability and proliferation of AML cells. In contrast, BDH1 knock-down promoted AML cell growth. Collectively, our results suggest the previously unappreciated anti-tumor role of BDH1 in AML, and low BDH1 expression predicts poor survival." @default.
- W3166064327 created "2021-06-22" @default.
- W3166064327 creator A5008770459 @default.
- W3166064327 creator A5009588850 @default.
- W3166064327 creator A5014211312 @default.
- W3166064327 creator A5028462736 @default.
- W3166064327 creator A5030342643 @default.
- W3166064327 creator A5031868763 @default.
- W3166064327 creator A5033599023 @default.
- W3166064327 creator A5034176758 @default.
- W3166064327 creator A5036951329 @default.
- W3166064327 creator A5039249865 @default.
- W3166064327 creator A5061507138 @default.
- W3166064327 creator A5065332989 @default.
- W3166064327 creator A5078812361 @default.
- W3166064327 creator A5079925141 @default.
- W3166064327 creator A5086567390 @default.
- W3166064327 date "2021-06-04" @default.
- W3166064327 modified "2023-09-25" @default.
- W3166064327 title "Anti-Tumor Effects of BDH1 in Acute Myeloid Leukemia" @default.
- W3166064327 cites W2000630389 @default.
- W3166064327 cites W2053612269 @default.
- W3166064327 cites W2070591736 @default.
- W3166064327 cites W2088253442 @default.
- W3166064327 cites W2104910696 @default.
- W3166064327 cites W2109065151 @default.
- W3166064327 cites W2112364188 @default.
- W3166064327 cites W2112743065 @default.
- W3166064327 cites W2116408939 @default.
- W3166064327 cites W2116858301 @default.
- W3166064327 cites W2118985891 @default.
- W3166064327 cites W2155631120 @default.
- W3166064327 cites W2171482205 @default.
- W3166064327 cites W2234115940 @default.
- W3166064327 cites W2343932903 @default.
- W3166064327 cites W2461928138 @default.
- W3166064327 cites W2521804113 @default.
- W3166064327 cites W2531874824 @default.
- W3166064327 cites W2559537906 @default.
- W3166064327 cites W2579809204 @default.
- W3166064327 cites W2585860512 @default.
- W3166064327 cites W2587156779 @default.
- W3166064327 cites W2603634294 @default.
- W3166064327 cites W2787647367 @default.
- W3166064327 cites W2809999132 @default.
- W3166064327 cites W2889621268 @default.
- W3166064327 cites W2892430625 @default.
- W3166064327 cites W2947242537 @default.
- W3166064327 cites W2965696960 @default.
- W3166064327 cites W2966025128 @default.
- W3166064327 cites W3006635774 @default.
- W3166064327 cites W3008847232 @default.
- W3166064327 cites W3015891595 @default.
- W3166064327 cites W3047309129 @default.
- W3166064327 cites W4231346141 @default.
- W3166064327 doi "https://doi.org/10.3389/fonc.2021.694594" @default.
- W3166064327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8213090" @default.
- W3166064327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34150668" @default.
- W3166064327 hasPublicationYear "2021" @default.
- W3166064327 type Work @default.
- W3166064327 sameAs 3166064327 @default.
- W3166064327 citedByCount "5" @default.
- W3166064327 countsByYear W31660643272021 @default.
- W3166064327 countsByYear W31660643272022 @default.
- W3166064327 crossrefType "journal-article" @default.
- W3166064327 hasAuthorship W3166064327A5008770459 @default.
- W3166064327 hasAuthorship W3166064327A5009588850 @default.
- W3166064327 hasAuthorship W3166064327A5014211312 @default.
- W3166064327 hasAuthorship W3166064327A5028462736 @default.
- W3166064327 hasAuthorship W3166064327A5030342643 @default.
- W3166064327 hasAuthorship W3166064327A5031868763 @default.
- W3166064327 hasAuthorship W3166064327A5033599023 @default.
- W3166064327 hasAuthorship W3166064327A5034176758 @default.
- W3166064327 hasAuthorship W3166064327A5036951329 @default.
- W3166064327 hasAuthorship W3166064327A5039249865 @default.
- W3166064327 hasAuthorship W3166064327A5061507138 @default.
- W3166064327 hasAuthorship W3166064327A5065332989 @default.
- W3166064327 hasAuthorship W3166064327A5078812361 @default.
- W3166064327 hasAuthorship W3166064327A5079925141 @default.
- W3166064327 hasAuthorship W3166064327A5086567390 @default.
- W3166064327 hasBestOaLocation W31660643271 @default.
- W3166064327 hasConcept C10205521 @default.
- W3166064327 hasConcept C104317684 @default.
- W3166064327 hasConcept C109159458 @default.
- W3166064327 hasConcept C127561419 @default.
- W3166064327 hasConcept C203014093 @default.
- W3166064327 hasConcept C2778461978 @default.
- W3166064327 hasConcept C2778729363 @default.
- W3166064327 hasConcept C2779282312 @default.
- W3166064327 hasConcept C2780942790 @default.
- W3166064327 hasConcept C28328180 @default.
- W3166064327 hasConcept C502942594 @default.
- W3166064327 hasConcept C54355233 @default.
- W3166064327 hasConcept C62112901 @default.
- W3166064327 hasConcept C71924100 @default.
- W3166064327 hasConcept C81885089 @default.
- W3166064327 hasConcept C86803240 @default.
- W3166064327 hasConcept C95444343 @default.
- W3166064327 hasConceptScore W3166064327C10205521 @default.
- W3166064327 hasConceptScore W3166064327C104317684 @default.