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• W3166075723 abstract "One of the characteristics of the failing human heart is a significant alteration in its energy metabolism. Recently, a ketone body, β-hydroxybutyrate (β-OHB) has been implicated in the failing heart’s energy metabolism as an alternative “fuel source.” Utilization of β-OHB in the failing heart increases, and this serves as a “fuel switch” that has been demonstrated to become an adaptive response to stress during the heart failure progression in both diabetic and non-diabetic patients. In addition to serving as an alternative “fuel,” β-OHB represents a signaling molecule that acts as an endogenous histone deacetylase (HDAC) inhibitor. It can increase histone acetylation or lysine acetylation of other signaling molecules. β-OHB has been shown to decrease the production of reactive oxygen species and activate autophagy. Moreover, β-OHB works as an NLR family pyrin domain-containing protein 3 (Nlrp3) inflammasome inhibitor and reduces Nlrp3-mediated inflammatory responses. It has also been reported that β-OHB plays a role in transcriptional or post-translational regulations of various genes’ expression. Increasing β-OHB levels prior to ischemia/reperfusion injury results in a reduced infarct size in rodents, likely due to the signaling function of β-OHB in addition to its role in providing energy. Sodium-glucose co-transporter-2 (SGLT2) inhibitors have been shown to exert strong beneficial effects on the cardiovascular system. They are also capable of increasing the production of β-OHB, which may partially explain their clinical efficacy. Despite all of the beneficial effects of β-OHB, some studies have shown detrimental effects of long-term exposure to β-OHB. Furthermore, not all means of increasing β-OHB levels in the heart are equally effective in treating heart failure. The best timing and therapeutic strategies for the delivery of β-OHB to treat heart disease are unknown and yet to be determined. In this review, we focus on the crucial role of ketone bodies, particularly β-OHB, as both an energy source and a signaling molecule in the stressed heart and the overall therapeutic potential of this compound for cardiovascular diseases." @default.
• W3166075723 created "2021-06-22" @default.
• W3166075723 creator A5037069754 @default.
• W3166075723 creator A5075596275 @default.
• W3166075723 creator A5083685156 @default.
• W3166075723 date "2021-06-08" @default.
• W3166075723 modified "2023-10-18" @default.
• W3166075723 title "Beta-Hydroxybutyrate, Friend or Foe for Stressed Hearts" @default.
• W3166075723 cites W1834962231 @default.
• W3166075723 cites W1971666606 @default.
• W3166075723 cites W1972483153 @default.
• W3166075723 cites W1982345388 @default.
• W3166075723 cites W1983813327 @default.
• W3166075723 cites W1992670654 @default.
• W3166075723 cites W1993772368 @default.
• W3166075723 cites W1993976394 @default.
• W3166075723 cites W1996042816 @default.
• W3166075723 cites W1996061153 @default.
• W3166075723 cites W1999259221 @default.
• W3166075723 cites W2003154208 @default.
• W3166075723 cites W2012425798 @default.
• W3166075723 cites W2016902863 @default.
• W3166075723 cites W2018308829 @default.
• W3166075723 cites W2020647227 @default.
• W3166075723 cites W2021517048 @default.
• W3166075723 cites W2036551825 @default.
• W3166075723 cites W2044176656 @default.
• W3166075723 cites W2058065156 @default.
• W3166075723 cites W2061059566 @default.
• W3166075723 cites W2079224025 @default.
• W3166075723 cites W2081262717 @default.
• W3166075723 cites W2089503694 @default.
• W3166075723 cites W2090600090 @default.
• W3166075723 cites W2109037116 @default.
• W3166075723 cites W2110824259 @default.
• W3166075723 cites W2112351720 @default.
• W3166075723 cites W2114445980 @default.
• W3166075723 cites W2117216951 @default.
• W3166075723 cites W2127189135 @default.
• W3166075723 cites W2127500778 @default.
• W3166075723 cites W2131007152 @default.
• W3166075723 cites W2131438908 @default.
• W3166075723 cites W2132197309 @default.
• W3166075723 cites W2133469996 @default.
• W3166075723 cites W2134619125 @default.
• W3166075723 cites W2136503478 @default.
• W3166075723 cites W2137225377 @default.
• W3166075723 cites W2137855436 @default.
• W3166075723 cites W2146264128 @default.
• W3166075723 cites W2151345870 @default.
• W3166075723 cites W2157096314 @default.
• W3166075723 cites W2157201312 @default.
• W3166075723 cites W2158025896 @default.
• W3166075723 cites W2164352080 @default.
• W3166075723 cites W2165316137 @default.
• W3166075723 cites W2166613497 @default.
• W3166075723 cites W2168484037 @default.
• W3166075723 cites W2168854431 @default.
• W3166075723 cites W2171706252 @default.
• W3166075723 cites W2181728476 @default.
• W3166075723 cites W2253712555 @default.
• W3166075723 cites W2256066116 @default.
• W3166075723 cites W2274126817 @default.
• W3166075723 cites W2286317334 @default.
• W3166075723 cites W2297835124 @default.
• W3166075723 cites W2309791126 @default.
• W3166075723 cites W2313390873 @default.
• W3166075723 cites W2337350186 @default.
• W3166075723 cites W2403029062 @default.
• W3166075723 cites W2484301708 @default.
• W3166075723 cites W2486445835 @default.
• W3166075723 cites W2522923643 @default.
• W3166075723 cites W2564174751 @default.
• W3166075723 cites W2587156779 @default.
• W3166075723 cites W2587843731 @default.
• W3166075723 cites W2588251211 @default.
• W3166075723 cites W2608794164 @default.
• W3166075723 cites W2626446274 @default.
• W3166075723 cites W2664551728 @default.
• W3166075723 cites W2742731108 @default.
• W3166075723 cites W2744221345 @default.
• W3166075723 cites W2761703425 @default.
• W3166075723 cites W2767848831 @default.
• W3166075723 cites W2768492618 @default.
• W3166075723 cites W2775570563 @default.
• W3166075723 cites W2803030267 @default.
• W3166075723 cites W2809295497 @default.
• W3166075723 cites W2886295148 @default.
• W3166075723 cites W2888544493 @default.
• W3166075723 cites W2889590224 @default.
• W3166075723 cites W2890368241 @default.
• W3166075723 cites W2896968341 @default.
• W3166075723 cites W2898943946 @default.
• W3166075723 cites W2900413769 @default.
• W3166075723 cites W2903904023 @default.
• W3166075723 cites W2904682193 @default.
• W3166075723 cites W2913394347 @default.
• W3166075723 cites W2917226475 @default.
• W3166075723 cites W2917390463 @default.
• W3166075723 cites W2920947723 @default.

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