Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166118562> ?p ?o ?g. }
- W3166118562 endingPage "837" @default.
- W3166118562 startingPage "837" @default.
- W3166118562 abstract "Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute to numerous disorders. The down-regulation of human cathepsin D is associated with neurodegenerative disorders, such as neuronal ceroid lipofuscinosis. On the other hand, its excessive levels outside lysosomes and the cell membrane lead to tumor growth, migration, invasion and angiogenesis. Therefore, targeting cathepsin D could provide significant diagnostic benefits and new avenues of therapy. Herein, we provide a brief overview of cathepsin D structure, regulation, function, and its role in the progression of many diseases and the therapeutic potentialities of natural and synthetic inhibitors and activators of this protease." @default.
- W3166118562 created "2021-06-22" @default.
- W3166118562 creator A5020547602 @default.
- W3166118562 creator A5027876593 @default.
- W3166118562 creator A5041901471 @default.
- W3166118562 creator A5042813572 @default.
- W3166118562 creator A5055136443 @default.
- W3166118562 creator A5056440307 @default.
- W3166118562 creator A5067754299 @default.
- W3166118562 creator A5070722851 @default.
- W3166118562 creator A5084909220 @default.
- W3166118562 creator A5089887145 @default.
- W3166118562 date "2021-06-05" @default.
- W3166118562 modified "2023-10-18" @default.
- W3166118562 title "Cathepsin D—Managing the Delicate Balance" @default.
- W3166118562 cites W109988810 @default.
- W3166118562 cites W1484795973 @default.
- W3166118562 cites W1486197790 @default.
- W3166118562 cites W1560487523 @default.
- W3166118562 cites W1771394546 @default.
- W3166118562 cites W1853148353 @default.
- W3166118562 cites W1907174433 @default.
- W3166118562 cites W1948319191 @default.
- W3166118562 cites W1972708772 @default.
- W3166118562 cites W1978158294 @default.
- W3166118562 cites W1980738763 @default.
- W3166118562 cites W1994263020 @default.
- W3166118562 cites W1998478158 @default.
- W3166118562 cites W2004024321 @default.
- W3166118562 cites W2010717540 @default.
- W3166118562 cites W2010800171 @default.
- W3166118562 cites W2012033013 @default.
- W3166118562 cites W2012855221 @default.
- W3166118562 cites W2013314062 @default.
- W3166118562 cites W2016995602 @default.
- W3166118562 cites W2022649483 @default.
- W3166118562 cites W2044506403 @default.
- W3166118562 cites W2054241093 @default.
- W3166118562 cites W2055897605 @default.
- W3166118562 cites W2056182070 @default.
- W3166118562 cites W2058813579 @default.
- W3166118562 cites W2059909690 @default.
- W3166118562 cites W2067193602 @default.
- W3166118562 cites W2073012291 @default.
- W3166118562 cites W2073066672 @default.
- W3166118562 cites W2076407831 @default.
- W3166118562 cites W2078846752 @default.
- W3166118562 cites W2085661569 @default.
- W3166118562 cites W2094504380 @default.
- W3166118562 cites W2095004571 @default.
- W3166118562 cites W2106043356 @default.
- W3166118562 cites W2112333706 @default.
- W3166118562 cites W2112355597 @default.
- W3166118562 cites W2115060890 @default.
- W3166118562 cites W2127524206 @default.
- W3166118562 cites W2134369114 @default.
- W3166118562 cites W2141195472 @default.
- W3166118562 cites W2141268120 @default.
- W3166118562 cites W2145396101 @default.
- W3166118562 cites W2147129952 @default.
- W3166118562 cites W2148566118 @default.
- W3166118562 cites W2154959406 @default.
- W3166118562 cites W2155738133 @default.
- W3166118562 cites W2161543439 @default.
- W3166118562 cites W2164231548 @default.
- W3166118562 cites W2175789104 @default.
- W3166118562 cites W2194130644 @default.
- W3166118562 cites W2225842833 @default.
- W3166118562 cites W223962917 @default.
- W3166118562 cites W2277130721 @default.
- W3166118562 cites W2290840312 @default.
- W3166118562 cites W2342739937 @default.
- W3166118562 cites W2397541480 @default.
- W3166118562 cites W2419588819 @default.
- W3166118562 cites W2492124067 @default.
- W3166118562 cites W2521057789 @default.
- W3166118562 cites W2588205705 @default.
- W3166118562 cites W2595479073 @default.
- W3166118562 cites W2595648898 @default.
- W3166118562 cites W2604909312 @default.
- W3166118562 cites W2609025041 @default.
- W3166118562 cites W2614918224 @default.
- W3166118562 cites W2616052569 @default.
- W3166118562 cites W2619414114 @default.
- W3166118562 cites W2728497530 @default.
- W3166118562 cites W2738470169 @default.
- W3166118562 cites W2747319570 @default.
- W3166118562 cites W2755130003 @default.
- W3166118562 cites W2763028934 @default.
- W3166118562 cites W2765409299 @default.
- W3166118562 cites W2769842768 @default.
- W3166118562 cites W2771305340 @default.
- W3166118562 cites W2772796280 @default.
- W3166118562 cites W2773041637 @default.
- W3166118562 cites W2773404756 @default.
- W3166118562 cites W2786028164 @default.
- W3166118562 cites W2789633344 @default.
- W3166118562 cites W2791199363 @default.