FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166128440> ?p ?o ?g. }

• W3166128440 abstract "Abstract Stimulant use, including cocaine, often occurs in a social context whose influence is important to understand to decrease intake and reduce associated harms. Given the regulatory role of the subthalamic nucleus (STN) on cocaine intake and emotions, we investigate its role on such influence of social context on cocaine intake. We explored the influence of peer presence and familiarity on the frequency of self-administered cocaine and its neurobiological basis. We first compared cocaine intake in various conditions (alone or with peers with different characteristics: observing or self-administering, familiar or not, cocaine-naive or not, dominant or subordinate) in rats (n=90). The risk of drug consumption was reduced when a peer was present, observing or self-administering as well, and further diminished when the peer was unfamiliar (vs familiar). The presence of a cocaine-naive peer further decreased cocaine consumption. The presence of a non-familiar and drug-naive peer represents thus key conditions to diminish cocaine intake. We tested the effects of STN lesions in these various conditions and also conducted social experiments to validate the role of STN in social cognition. The STN lesion by itself reduced cocaine intake to the level reached in presence of a stranger naïve peer and affected social cognition, positioning the STN as one neurobiological substrate of social influence on drug intake. Finally, with a translational research approach, we compared the drug intake in these conditions in human drug users (n=77). This human study confirmed the beneficial effect of social presence, especially of strangers. Our results indirectly support the use of social interventions and harm reduction strategies, in particular supervised consumption rooms for stimulant users." @default.
• W3166128440 created "2021-06-22" @default.
• W3166128440 creator A5005576211 @default.
• W3166128440 creator A5008490460 @default.
• W3166128440 creator A5016984939 @default.
• W3166128440 creator A5036189113 @default.
• W3166128440 creator A5039489560 @default.
• W3166128440 creator A5053680286 @default.
• W3166128440 creator A5066655405 @default.
• W3166128440 creator A5068015568 @default.
• W3166128440 creator A5070807274 @default.
• W3166128440 creator A5079614854 @default.
• W3166128440 creator A5081141003 @default.
• W3166128440 creator A5083574223 @default.
• W3166128440 creator A5085208411 @default.
• W3166128440 creator A5087861645 @default.
• W3166128440 date "2021-06-08" @default.
• W3166128440 modified "2023-10-18" @default.
• W3166128440 title "Peer presence and familiarity as key factors to reduce cocaine intake: an effect mediated by the Subthalamic Nucleus" @default.
• W3166128440 cites W1540649781 @default.
• W3166128440 cites W1589737427 @default.
• W3166128440 cites W1808212086 @default.
• W3166128440 cites W1910384141 @default.
• W3166128440 cites W1916096396 @default.
• W3166128440 cites W1970611061 @default.
• W3166128440 cites W1970644932 @default.
• W3166128440 cites W1974322969 @default.
• W3166128440 cites W1988409568 @default.
• W3166128440 cites W1991283773 @default.
• W3166128440 cites W1996236954 @default.
• W3166128440 cites W1997398141 @default.
• W3166128440 cites W1999827951 @default.
• W3166128440 cites W2001297824 @default.
• W3166128440 cites W2001428261 @default.
• W3166128440 cites W2002489793 @default.
• W3166128440 cites W2003392460 @default.
• W3166128440 cites W2003446496 @default.
• W3166128440 cites W2006049216 @default.
• W3166128440 cites W2009350379 @default.
• W3166128440 cites W2011741559 @default.
• W3166128440 cites W2012248381 @default.
• W3166128440 cites W2013654667 @default.
• W3166128440 cites W2019693105 @default.
• W3166128440 cites W2034864387 @default.
• W3166128440 cites W2041716049 @default.
• W3166128440 cites W2041999291 @default.
• W3166128440 cites W2051188477 @default.
• W3166128440 cites W2052047559 @default.
• W3166128440 cites W2055084871 @default.
• W3166128440 cites W2058569645 @default.
• W3166128440 cites W2059756725 @default.
• W3166128440 cites W2060588252 @default.
• W3166128440 cites W2074881763 @default.
• W3166128440 cites W2081404565 @default.
• W3166128440 cites W2084233554 @default.
• W3166128440 cites W2084677746 @default.
• W3166128440 cites W2095221122 @default.
• W3166128440 cites W2098215304 @default.
• W3166128440 cites W2099245189 @default.
• W3166128440 cites W2100054850 @default.
• W3166128440 cites W2103018978 @default.
• W3166128440 cites W2109091674 @default.
• W3166128440 cites W2122560062 @default.
• W3166128440 cites W2124135388 @default.
• W3166128440 cites W2124454555 @default.
• W3166128440 cites W2128211282 @default.
• W3166128440 cites W2145049392 @default.
• W3166128440 cites W2149860264 @default.
• W3166128440 cites W2150483785 @default.
• W3166128440 cites W2152995441 @default.
• W3166128440 cites W2153421686 @default.
• W3166128440 cites W2157436954 @default.
• W3166128440 cites W2168138675 @default.
• W3166128440 cites W2317172122 @default.
• W3166128440 cites W2409888425 @default.
• W3166128440 cites W2513981496 @default.
• W3166128440 cites W2607288014 @default.
• W3166128440 cites W2623764781 @default.
• W3166128440 cites W2746127402 @default.
• W3166128440 cites W2806476950 @default.
• W3166128440 cites W2895626514 @default.
• W3166128440 cites W2897863430 @default.
• W3166128440 cites W2917179929 @default.
• W3166128440 cites W2951725240 @default.
• W3166128440 cites W3016048142 @default.
• W3166128440 cites W4249826380 @default.
• W3166128440 cites W783685611 @default.
• W3166128440 doi "https://doi.org/10.1101/2021.06.08.447497" @default.
• W3166128440 hasPublicationYear "2021" @default.
• W3166128440 type Work @default.
• W3166128440 sameAs 3166128440 @default.
• W3166128440 citedByCount "1" @default.
• W3166128440 countsByYear W31661284402023 @default.
• W3166128440 crossrefType "posted-content" @default.
• W3166128440 hasAuthorship W3166128440A5005576211 @default.
• W3166128440 hasAuthorship W3166128440A5008490460 @default.
• W3166128440 hasAuthorship W3166128440A5016984939 @default.
• W3166128440 hasAuthorship W3166128440A5036189113 @default.
• W3166128440 hasAuthorship W3166128440A5039489560 @default.
• W3166128440 hasAuthorship W3166128440A5053680286 @default.

• next