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- W3166137082 abstract "This paper concerns the facile preparation of alginate beads encapsulating layered double hydroxide (LDH) intercalated with diclofenac sodium as drug delivery systems. To better evaluate the effect of LDH carrier, alginate beads loaded with free diclofenac were also prepared. Composites hydrogel beads were ionotropically crosslinked in CaCl 2 solution at 4 °C. Thermal and barrier properties were evaluated and correlated with the presence of the inorganic phase. Swelling behavior was investigated over time. Release kinetics of diclofenac at different pH and temperatures were evaluated. The diclofenac release behavior appeared to be affected by the presence of LDH, the pH of release medium and the temperature allowing for fabricating a sustainable composite characterized by a triggered drug release rate. Finally, empirical relationships correlating the drug diffusion as a function of temperature and pH were extrapolated. • LDH intercalated with diclofenac loaded in alginate beads were fabricated. • Release kinetics of diclofenac were modeled by applying the Baker-Lonsdale model. • The effects of temperature and pH on the release kinetics of diclofenac were studied. • The drug release was evaluated simulating the in vivo processes at different pHs." @default.
- W3166137082 created "2021-06-22" @default.
- W3166137082 creator A5028940104 @default.
- W3166137082 creator A5042283205 @default.
- W3166137082 date "2021-08-01" @default.
- W3166137082 modified "2023-10-03" @default.
- W3166137082 title "Facile preparation of layered double hydroxide (LDH)-alginate beads as sustainable system for the triggered release of diclofenac: Effect of pH and temperature on release rate" @default.
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- W3166137082 doi "https://doi.org/10.1016/j.ijbiomac.2021.05.217" @default.
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