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- W3166151111 abstract "Reactive intermediates formed during cell membrane metabolism can contribute to carcinogenesis through oxidative damage to DNA. Potential chemopreventive effects of selenium supplementation have been attributed to the antioxidant activity of selenocysteine residues in selenoproteins. Selenoprotein P (SelP) is an extracellular glycoprotein that functions both in selenium distribution and as an antioxidant protein. The major objective of this study was to determine the effect of SelP on lipid hydroperoxides produced during the metabolism of arachidonic acid by 15-lipoxygenase-1. Enzymatic reduction of 15- hydroperoxyeicosatetraenoic acid (15-HpETE) by SelP was observed in a NADPH-coupled biochemical assay. Diphenylpyrenylphosphin was used to measure lipid hydroperoxides in SelP treated human embryonic kidney (HEK-293) cells following exposure to 15-HpETE. Lipid hydroperoxides increased with 15-HpETE treatment of cells, and SelP reduced this effect, even when the protein and metabolite were added simultaneously. This shows that SelP can work as an antioxidant enzyme against reactive intermediates formed during inflammation. This effect may serve to protect cells against the oxidative damage induced by these lipid metabolites. This work is supported by NCI grant CA115616" @default.
- W3166151111 created "2021-06-22" @default.
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- W3166151111 date "2010-04-01" @default.
- W3166151111 modified "2023-09-24" @default.
- W3166151111 title "Selenoprotein P reduces lipid hydroperoxides in human embryonic kidney cells following exposure to 15‐ hydroperoxyeicosatetraenoic acid" @default.
- W3166151111 doi "https://doi.org/10.1096/fasebj.24.1_supplement.916.7" @default.
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