Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166153578> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W3166153578 abstract "Meprin A is a matrix metalloproteinase highly expressed in the kidney and thought to play an important role in several causes of acute kidney injury (AKI). To address the role of meprin A in the early and late phases of renal microcirculatory dysfunction associated with sepsis, we treated mice at 30 min prior to or 7 h post cecal ligation and puncture (CLP) with the meprin A inhibitor actinonin (20 mg/kg). Intravital videomicroscopy was utilized to image renal cortical peritubular capillary perfusion and reactive nitrogen species generation (RNS) using dihydrorhodamine 123 (DHR) at 18 h post CLP. Actinonin prevented the fall in renal capillary perfusion and the increase in RNS at 18 h even when administered at 7 h post CLP without affecting systemic NO generation. Importantly, even late administration of actinonin preserved renal function (as measured by BUN). These data suggest that meprin A may play an important role in the microcirculatory failure and oxidative stress associated with sepsis-induced AKI. Moreover, actinonin should be evaluated further as a possible therapeutic agent because an agent that is protective even after the onset of sepsis would have a great impact on patient outcome. Supported by NIH DK075991." @default.
- W3166153578 created "2021-06-22" @default.
- W3166153578 creator A5004916852 @default.
- W3166153578 creator A5013765402 @default.
- W3166153578 creator A5044761881 @default.
- W3166153578 creator A5073683204 @default.
- W3166153578 date "2010-04-01" @default.
- W3166153578 modified "2023-09-23" @default.
- W3166153578 title "Delayed treatment with actinonin, a meprin A inhibitor, protects the renal microcirculation and renal function during sepsis in mice" @default.
- W3166153578 doi "https://doi.org/10.1096/fasebj.24.1_supplement.968.2" @default.
- W3166153578 hasPublicationYear "2010" @default.
- W3166153578 type Work @default.
- W3166153578 sameAs 3166153578 @default.
- W3166153578 citedByCount "0" @default.
- W3166153578 crossrefType "journal-article" @default.
- W3166153578 hasAuthorship W3166153578A5004916852 @default.
- W3166153578 hasAuthorship W3166153578A5013765402 @default.
- W3166153578 hasAuthorship W3166153578A5044761881 @default.
- W3166153578 hasAuthorship W3166153578A5073683204 @default.
- W3166153578 hasConcept C126322002 @default.
- W3166153578 hasConcept C12722491 @default.
- W3166153578 hasConcept C159641895 @default.
- W3166153578 hasConcept C2778384902 @default.
- W3166153578 hasConcept C71924100 @default.
- W3166153578 hasConcept C98274493 @default.
- W3166153578 hasConceptScore W3166153578C126322002 @default.
- W3166153578 hasConceptScore W3166153578C12722491 @default.
- W3166153578 hasConceptScore W3166153578C159641895 @default.
- W3166153578 hasConceptScore W3166153578C2778384902 @default.
- W3166153578 hasConceptScore W3166153578C71924100 @default.
- W3166153578 hasConceptScore W3166153578C98274493 @default.
- W3166153578 hasFunder F4320332161 @default.
- W3166153578 hasIssue "S1" @default.
- W3166153578 hasLocation W31661535781 @default.
- W3166153578 hasOpenAccess W3166153578 @default.
- W3166153578 hasPrimaryLocation W31661535781 @default.
- W3166153578 hasRelatedWork W1969830406 @default.
- W3166153578 hasRelatedWork W1970095991 @default.
- W3166153578 hasRelatedWork W1979876108 @default.
- W3166153578 hasRelatedWork W2059061787 @default.
- W3166153578 hasRelatedWork W2071226507 @default.
- W3166153578 hasRelatedWork W2156449116 @default.
- W3166153578 hasRelatedWork W2313143502 @default.
- W3166153578 hasRelatedWork W2326608089 @default.
- W3166153578 hasRelatedWork W2328668506 @default.
- W3166153578 hasRelatedWork W2412336661 @default.
- W3166153578 hasRelatedWork W2536739777 @default.
- W3166153578 hasRelatedWork W2570969530 @default.
- W3166153578 hasRelatedWork W2749957791 @default.
- W3166153578 hasRelatedWork W2775655548 @default.
- W3166153578 hasRelatedWork W3033688509 @default.
- W3166153578 hasRelatedWork W3115762799 @default.
- W3166153578 hasRelatedWork W3201721663 @default.
- W3166153578 hasRelatedWork W3209607653 @default.
- W3166153578 hasRelatedWork W389552120 @default.
- W3166153578 hasRelatedWork W3101291361 @default.
- W3166153578 hasVolume "24" @default.
- W3166153578 isParatext "false" @default.
- W3166153578 isRetracted "false" @default.
- W3166153578 magId "3166153578" @default.
- W3166153578 workType "article" @default.