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- W3166154560 abstract "Dermatomyositis (DM) is a systemic autoimmune disease affecting multiple organs, including the skeletal muscle, skin, and lungs. Although DM disease mechanisms are incompletely understood, accumulating evidence suggests that interferons may play a significant role. Consequently, it is of considerable interest that drugs blocking the activity of interferons by inhibiting the Janus Kinase/Signal Transducer and Activator of Transcription (JAK-STAT) pathway have been approved for use in other autoimmune diseases. This manuscript will examine the IFN pathways and their importance in DM, review the existing literature on the use of JAK-STAT inhibitors in patients with adult or juvenile DM, and discuss the potential utility of JAK-STAT inhibitors to treat this disease. Recent reports suggest that muscle and skin involvement in patients with either adult or juvenile DM responds favorably to JAK-STAT inhibitors. Moreover, preliminary data indicates that JAK-STAT inhibitors may be useful to treat clinical manifestations of this disease that are complicated to manage otherwise, such as calcinosis or rapidly progressive interstitial lung disease in DM patients with anti-MDA5 autoantibodies. An increasing number of reports suggest that JAK-STAT inhibitors may be useful to treat the varied manifestations of adult and juvenile DM. However, as most studies were either small or lacked appropriate comparators, further research will be necessary to define the role of these drugs in DM treatment." @default.
- W3166154560 created "2021-06-22" @default.
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- W3166154560 date "2021-06-14" @default.
- W3166154560 modified "2023-10-18" @default.
- W3166154560 title "Inhibiting Interferon Pathways in Dermatomyositis: Rationale and Preliminary Evidence" @default.
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- W3166154560 cites W2000618386 @default.
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- W3166154560 cites W2021382556 @default.
- W3166154560 cites W2033903988 @default.
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- W3166154560 doi "https://doi.org/10.1007/s40674-021-00182-1" @default.
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