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- W3166154691 abstract "Abstract Diversity of cell-types that collectively shape the cortical microcircuit ensures the necessary computational richness to orchestrate a wide variety of behaviors. The information content embedded in spiking activity of identified cell-types remain unclear to a large extent. Here, we recorded spike responses upon whisker touch of anatomically identified excitatory cell-types in primary somatosensory cortex in naive, untrained rats. We find major differences across layers and cell-types. The temporal structure of spontaneous spiking contains high-frequency bursts (≥100 Hz) in all morphological cell-types but a significant increase upon whisker touch is restricted to layer L5 thick-tufted pyramids (L5tts) and thus provides a distinct neurophysiological signature. We find that whisker touch can also be decoded from L5tt bursting, but not from other cell-types. We observed high-frequency bursts in L5tts projecting to different subcortical regions, including thalamus, midbrain and brainstem. We conclude that bursts in L5tts allow accurate coding and decoding of exploratory whisker touch." @default.
- W3166154691 created "2021-06-22" @default.
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- W3166154691 date "2021-06-10" @default.
- W3166154691 modified "2023-10-11" @default.
- W3166154691 title "High-frequency burst spiking in layer 5 thick-tufted pyramids of rat primary somatosensory cortex encodes exploratory touch" @default.
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- W3166154691 doi "https://doi.org/10.1038/s42003-021-02241-8" @default.
- W3166154691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8192911" @default.
- W3166154691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34112934" @default.
- W3166154691 hasPublicationYear "2021" @default.
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