FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166155517> ?p ?o ?g. }

• W3166155517 endingPage "1405" @default.
• W3166155517 startingPage "1405" @default.
• W3166155517 abstract "Age-related macular degeneration (AMD) is a retinal disease leading to impaired vision. Cigarette smoke increases the risk for developing AMD by causing increased reactive oxygen species (ROS) production and damage in the retinal pigment epithelium (RPE). We have previously shown that the cigarette tar component hydroquinone causes oxidative stress in human RPE cells. In the present study, we investigated the propensity of hydroquinone to induce the secretion of interleukin (IL)-1β and IL-18. The activation of these cytokines is usually regulated by the Nucleotide-binding domain, Leucine-rich repeat, and Pyrin domain 3 (NLRP3) inflammasome. ARPE-19 cells were exposed to hydroquinone, and cell viability was monitored using the lactate dehydrogenase (LDH) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide salt (MTT) assays. Enzyme-linked immunosorbent assays (ELISAs) were used to measure the levels of proinflammatory cytokines IL-1β and IL-18 as well as NLRP3, caspase-1, and poly (ADP-ribose) polymerase (PARP). Hydroquinone did not change IL-1β release but significantly increased the secretion of IL-18. Cytoplasmic NLRP3 levels increased after the hydroquinone treatment of IL-1α-primed RPE cells, but IL-18 was equally released from primed and nonprimed cells. Hydroquinone reduced the intracellular levels of PARP, which were restored by treatment with the ROS scavenger N-acetyl-cysteine (NAC). NAC concurrently reduced the NLRP3 levels but had no effect on IL-18 release. In contrast, the NADPH oxidase inhibitor ammonium pyrrolidinedithiocarbamate (APDC) reduced the release of IL-18 but had no effect on the NLRP3 levels. Collectively, hydroquinone caused DNA damage seen as reduced intracellular PARP levels and induced NLRP3-independent IL-18 secretion in human RPE cells." @default.
• W3166155517 created "2021-06-22" @default.
• W3166155517 creator A5021448617 @default.
• W3166155517 creator A5037753197 @default.
• W3166155517 creator A5056896333 @default.
• W3166155517 creator A5071846201 @default.
• W3166155517 creator A5084970795 @default.
• W3166155517 date "2021-06-06" @default.
• W3166155517 modified "2023-10-16" @default.
• W3166155517 title "Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells" @default.
• W3166155517 cites W1636793459 @default.
• W3166155517 cites W1885912605 @default.
• W3166155517 cites W1955806191 @default.
• W3166155517 cites W1970837608 @default.
• W3166155517 cites W1985144223 @default.
• W3166155517 cites W1988950887 @default.
• W3166155517 cites W1990289864 @default.
• W3166155517 cites W2005487633 @default.
• W3166155517 cites W2007014682 @default.
• W3166155517 cites W2011876741 @default.
• W3166155517 cites W2016435749 @default.
• W3166155517 cites W2027172883 @default.
• W3166155517 cites W2033919269 @default.
• W3166155517 cites W2034465933 @default.
• W3166155517 cites W2034682665 @default.
• W3166155517 cites W2050516456 @default.
• W3166155517 cites W2051332099 @default.
• W3166155517 cites W2059563381 @default.
• W3166155517 cites W2064856766 @default.
• W3166155517 cites W2081690682 @default.
• W3166155517 cites W2086919198 @default.
• W3166155517 cites W2088402629 @default.
• W3166155517 cites W2089944736 @default.
• W3166155517 cites W2090921808 @default.
• W3166155517 cites W2090990681 @default.
• W3166155517 cites W2097984332 @default.
• W3166155517 cites W2111586778 @default.
• W3166155517 cites W2125843275 @default.
• W3166155517 cites W2148300265 @default.
• W3166155517 cites W2150452566 @default.
• W3166155517 cites W2165275387 @default.
• W3166155517 cites W2167644235 @default.
• W3166155517 cites W2189185302 @default.
• W3166155517 cites W2264982258 @default.
• W3166155517 cites W2269181396 @default.
• W3166155517 cites W2314903700 @default.
• W3166155517 cites W2326523156 @default.
• W3166155517 cites W2410873461 @default.
• W3166155517 cites W2474736177 @default.
• W3166155517 cites W2572273736 @default.
• W3166155517 cites W2611674820 @default.
• W3166155517 cites W2737555531 @default.
• W3166155517 cites W2757293862 @default.
• W3166155517 cites W2759961393 @default.
• W3166155517 cites W2776988169 @default.
• W3166155517 cites W2783751627 @default.
• W3166155517 cites W2799712672 @default.
• W3166155517 cites W2888458308 @default.
• W3166155517 cites W2911549495 @default.
• W3166155517 cites W2958779309 @default.
• W3166155517 cites W3010988898 @default.
• W3166155517 cites W3011133222 @default.
• W3166155517 cites W3012076471 @default.
• W3166155517 cites W3047400254 @default.
• W3166155517 cites W4293247451 @default.
• W3166155517 cites W3120519649 @default.
• W3166155517 doi "https://doi.org/10.3390/cells10061405" @default.
• W3166155517 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8229790" @default.
• W3166155517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34204067" @default.
• W3166155517 hasPublicationYear "2021" @default.
• W3166155517 type Work @default.
• W3166155517 sameAs 3166155517 @default.
• W3166155517 citedByCount "4" @default.
• W3166155517 countsByYear W31661555172022 @default.
• W3166155517 countsByYear W31661555172023 @default.
• W3166155517 crossrefType "journal-article" @default.
• W3166155517 hasAuthorship W3166155517A5021448617 @default.
• W3166155517 hasAuthorship W3166155517A5037753197 @default.
• W3166155517 hasAuthorship W3166155517A5056896333 @default.
• W3166155517 hasAuthorship W3166155517A5071846201 @default.
• W3166155517 hasAuthorship W3166155517A5084970795 @default.
• W3166155517 hasBestOaLocation W31661555171 @default.
• W3166155517 hasConcept C153911025 @default.
• W3166155517 hasConcept C164027704 @default.
• W3166155517 hasConcept C170493617 @default.
• W3166155517 hasConcept C185592680 @default.
• W3166155517 hasConcept C190283241 @default.
• W3166155517 hasConcept C203014093 @default.
• W3166155517 hasConcept C2776151105 @default.
• W3166155517 hasConcept C2776914184 @default.
• W3166155517 hasConcept C2777209026 @default.
• W3166155517 hasConcept C2777550763 @default.
• W3166155517 hasConcept C2778024200 @default.
• W3166155517 hasConcept C2779719074 @default.
• W3166155517 hasConcept C2780827179 @default.
• W3166155517 hasConcept C48349386 @default.
• W3166155517 hasConcept C53227056 @default.
• W3166155517 hasConcept C55493867 @default.

• next