FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166155592> ?p ?o ?g. }

• W3166155592 abstract "Background Several rare and common variants are associated with Parkinson’s disease. However, there is still an incomplete penetrance in the carriers of rare variants associated with Parkinson’s disease. To address this issue, we investigated whether a PRS calculated from significant GWAS SNPs affects the penetrance of Parkinson’s disease among carriers of rare monogenic variants in known Parkinson’s disease genes and those with a family history. Methods We calculated the PRS based on common variants and selected the carriers of rare monogenic variants by using the exome data from UK Biobank. Individuals were divided into three risk categories based on PRS: low (<10%), intermediate (10%-90%), and high (>90%) risk groups. We then compared how PRS affects Parkinson’s disease risk among carriers of rare monogenic variants and those with family-history. Results We observed a two-fold higher odds ratio for a carrier of a monogenic variant that had a high PRS (OR 4.07,95% CI, 1.72-8.08) compared to carriers with a low PRS (OR 1.91, 95% CI, 0.31-6.05). In the same line, carriers with a first-degree family history and with >90% PRS have even a higher risk of developing PD (OR 23.53, 95%CI 5.39-71.54) compared to those with <90% PRS (OR 9.54, 95% CI 3.32-21.65). Conclusions Our results show that PRS, carrier status, and family history contribute independently and additively to the Parkinson’s disease risk." @default.
• W3166155592 created "2021-06-22" @default.
• W3166155592 creator A5013713722 @default.
• W3166155592 creator A5016006994 @default.
• W3166155592 creator A5032669663 @default.
• W3166155592 creator A5051454986 @default.
• W3166155592 creator A5057437092 @default.
• W3166155592 creator A5061914842 @default.
• W3166155592 date "2021-06-09" @default.
• W3166155592 modified "2023-10-17" @default.
• W3166155592 title "Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson’s disease" @default.
• W3166155592 cites W1591882542 @default.
• W3166155592 cites W1984068087 @default.
• W3166155592 cites W1988494453 @default.
• W3166155592 cites W1997887791 @default.
• W3166155592 cites W2051978340 @default.
• W3166155592 cites W2099085143 @default.
• W3166155592 cites W2130187979 @default.
• W3166155592 cites W2154866190 @default.
• W3166155592 cites W2156289764 @default.
• W3166155592 cites W2178497502 @default.
• W3166155592 cites W2768406646 @default.
• W3166155592 cites W2782297377 @default.
• W3166155592 cites W2782715767 @default.
• W3166155592 cites W2895486342 @default.
• W3166155592 cites W2899124231 @default.
• W3166155592 cites W2901728784 @default.
• W3166155592 cites W2909714593 @default.
• W3166155592 cites W2958615822 @default.
• W3166155592 cites W2972937106 @default.
• W3166155592 cites W2986932567 @default.
• W3166155592 cites W2993040769 @default.
• W3166155592 cites W2996732250 @default.
• W3166155592 cites W3000974767 @default.
• W3166155592 cites W3001337291 @default.
• W3166155592 cites W3005546653 @default.
• W3166155592 cites W3029661147 @default.
• W3166155592 cites W3038648294 @default.
• W3166155592 cites W3046684455 @default.
• W3166155592 cites W3052902836 @default.
• W3166155592 cites W3084651803 @default.
• W3166155592 cites W3087930232 @default.
• W3166155592 cites W3134515557 @default.
• W3166155592 cites W2895909123 @default.
• W3166155592 doi "https://doi.org/10.1101/2021.06.06.21253270" @default.
• W3166155592 hasPublicationYear "2021" @default.
• W3166155592 type Work @default.
• W3166155592 sameAs 3166155592 @default.
• W3166155592 citedByCount "3" @default.
• W3166155592 countsByYear W31661555922022 @default.
• W3166155592 countsByYear W31661555922023 @default.
• W3166155592 crossrefType "posted-content" @default.
• W3166155592 hasAuthorship W3166155592A5013713722 @default.
• W3166155592 hasAuthorship W3166155592A5016006994 @default.
• W3166155592 hasAuthorship W3166155592A5032669663 @default.
• W3166155592 hasAuthorship W3166155592A5051454986 @default.
• W3166155592 hasAuthorship W3166155592A5057437092 @default.
• W3166155592 hasAuthorship W3166155592A5061914842 @default.
• W3166155592 hasBestOaLocation W31661555921 @default.
• W3166155592 hasConcept C104317684 @default.
• W3166155592 hasConcept C126322002 @default.
• W3166155592 hasConcept C127716648 @default.
• W3166155592 hasConcept C135763542 @default.
• W3166155592 hasConcept C137916694 @default.
• W3166155592 hasConcept C143998085 @default.
• W3166155592 hasConcept C144621757 @default.
• W3166155592 hasConcept C153209595 @default.
• W3166155592 hasConcept C156957248 @default.
• W3166155592 hasConcept C200544954 @default.
• W3166155592 hasConcept C2779134260 @default.
• W3166155592 hasConcept C2779734285 @default.
• W3166155592 hasConcept C2781179581 @default.
• W3166155592 hasConcept C54355233 @default.
• W3166155592 hasConcept C71924100 @default.
• W3166155592 hasConcept C86803240 @default.
• W3166155592 hasConceptScore W3166155592C104317684 @default.
• W3166155592 hasConceptScore W3166155592C126322002 @default.
• W3166155592 hasConceptScore W3166155592C127716648 @default.
• W3166155592 hasConceptScore W3166155592C135763542 @default.
• W3166155592 hasConceptScore W3166155592C137916694 @default.
• W3166155592 hasConceptScore W3166155592C143998085 @default.
• W3166155592 hasConceptScore W3166155592C144621757 @default.
• W3166155592 hasConceptScore W3166155592C153209595 @default.
• W3166155592 hasConceptScore W3166155592C156957248 @default.
• W3166155592 hasConceptScore W3166155592C200544954 @default.
• W3166155592 hasConceptScore W3166155592C2779134260 @default.
• W3166155592 hasConceptScore W3166155592C2779734285 @default.
• W3166155592 hasConceptScore W3166155592C2781179581 @default.
• W3166155592 hasConceptScore W3166155592C54355233 @default.
• W3166155592 hasConceptScore W3166155592C71924100 @default.
• W3166155592 hasConceptScore W3166155592C86803240 @default.
• W3166155592 hasLocation W31661555921 @default.
• W3166155592 hasLocation W31661555922 @default.
• W3166155592 hasLocation W31661555923 @default.
• W3166155592 hasOpenAccess W3166155592 @default.
• W3166155592 hasPrimaryLocation W31661555921 @default.
• W3166155592 hasRelatedWork W1988415656 @default.
• W3166155592 hasRelatedWork W1995885164 @default.
• W3166155592 hasRelatedWork W2079259619 @default.
• W3166155592 hasRelatedWork W2145882589 @default.

• next