FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166157660> ?p ?o ?g. }

• W3166157660 endingPage "1972" @default.
• W3166157660 startingPage "1959" @default.
• W3166157660 abstract "Circular RNAs (circRNAs) are covalently closed RNAs and are implicated in the development of non-small cell lung cancer (NSCLC). Here, we identified the precise actions of circRNA LIM domain binding 2 (circLDB2, hsa_circ_0069244) in non-squamous NSCLC development and drug sensitivity.CircLDB2, microRNA (miR)-346, and LIM and calponin-homology domains 1 (LIMCH1) were quantified by quantitative real-time polymerase chain reaction (qRT-PCR) or western blot. Ribonuclease R (RNase R), actinomycin D, and subcellular localization assays were used to characterize circLDB2. Cell proliferation and viability, colony formation, apoptosis, migration, and invasion were gauged by Cell Counting Kit-8 (CCK-8), colony formation, flow cytometry, wound-healing, and transwell assays, respectively. RNA immunoprecipitation (RIP), RNA pull-down, and dual-luciferase reporter assays were used to verify the direct relationship between miR-346 and circLDB2 or LIMCH1. Animal studies were performed to evaluate the impact of circLDB2 in vivo.CircLDB2 was underexpressed in non-squamous NSCLC and was identified as a bona fide circular transcript. Overexpression of circLDB2 impeded cell proliferation, migration, invasion, and enhanced apoptosis and cisplatin sensitivity in vitro, as well as promoted the antitumor effect of cisplatin in vivo. CircLDB2 regulated cell functional behaviors and cisplatin sensitivity by sponging miR-346. LIMCH1 was a direct and functional target of miR-346. Furthermore, circLDB2 acted as a competing endogenous RNA (ceRNA) for miR-346 to induce LIMCH1 expression.Our findings demonstrated that circLDB2 impeded non-squamous NSCLC development and enhanced cisplatin sensitivity partially by acting as a ceRNA, highlighting circLDB2 as a promising candidate for the development of novel antitumor therapies." @default.
• W3166157660 created "2021-06-22" @default.
• W3166157660 creator A5021058186 @default.
• W3166157660 creator A5031958075 @default.
• W3166157660 creator A5034942869 @default.
• W3166157660 creator A5065418938 @default.
• W3166157660 date "2021-06-06" @default.
• W3166157660 modified "2023-10-17" @default.
• W3166157660 title "Circular <scp>RNA circLDB2</scp> functions as a competing endogenous <scp>RNA</scp> to suppress development and promote cisplatin sensitivity in non‐squamous non‐small cell lung cancer" @default.
• W3166157660 cites W1892182006 @default.
• W3166157660 cites W2058835062 @default.
• W3166157660 cites W2130357378 @default.
• W3166157660 cites W2130687298 @default.
• W3166157660 cites W2137135650 @default.
• W3166157660 cites W2138885372 @default.
• W3166157660 cites W2160068229 @default.
• W3166157660 cites W2507722418 @default.
• W3166157660 cites W2538191697 @default.
• W3166157660 cites W2558335088 @default.
• W3166157660 cites W2559156610 @default.
• W3166157660 cites W2589289345 @default.
• W3166157660 cites W2591171938 @default.
• W3166157660 cites W2738581806 @default.
• W3166157660 cites W2743956930 @default.
• W3166157660 cites W2889646458 @default.
• W3166157660 cites W2892900345 @default.
• W3166157660 cites W2894150395 @default.
• W3166157660 cites W2914398011 @default.
• W3166157660 cites W2944131868 @default.
• W3166157660 cites W2946847644 @default.
• W3166157660 cites W2954261580 @default.
• W3166157660 cites W2955501917 @default.
• W3166157660 cites W2973095792 @default.
• W3166157660 cites W2982980789 @default.
• W3166157660 cites W2991370712 @default.
• W3166157660 cites W3023391621 @default.
• W3166157660 cites W3032392295 @default.
• W3166157660 cites W3045743937 @default.
• W3166157660 cites W3092020182 @default.
• W3166157660 cites W3097101725 @default.
• W3166157660 cites W3101151623 @default.
• W3166157660 doi "https://doi.org/10.1111/1759-7714.13993" @default.
• W3166157660 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8258361" @default.
• W3166157660 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34096174" @default.
• W3166157660 hasPublicationYear "2021" @default.
• W3166157660 type Work @default.
• W3166157660 sameAs 3166157660 @default.
• W3166157660 citedByCount "5" @default.
• W3166157660 countsByYear W31661576602021 @default.
• W3166157660 countsByYear W31661576602022 @default.
• W3166157660 countsByYear W31661576602023 @default.
• W3166157660 crossrefType "journal-article" @default.
• W3166157660 hasAuthorship W3166157660A5021058186 @default.
• W3166157660 hasAuthorship W3166157660A5031958075 @default.
• W3166157660 hasAuthorship W3166157660A5034942869 @default.
• W3166157660 hasAuthorship W3166157660A5065418938 @default.
• W3166157660 hasBestOaLocation W31661576602 @default.
• W3166157660 hasConcept C104317684 @default.
• W3166157660 hasConcept C145059251 @default.
• W3166157660 hasConcept C153911025 @default.
• W3166157660 hasConcept C2775893923 @default.
• W3166157660 hasConcept C2776694085 @default.
• W3166157660 hasConcept C2778239845 @default.
• W3166157660 hasConcept C502942594 @default.
• W3166157660 hasConcept C54355233 @default.
• W3166157660 hasConcept C55493867 @default.
• W3166157660 hasConcept C60365752 @default.
• W3166157660 hasConcept C62112901 @default.
• W3166157660 hasConcept C62203573 @default.
• W3166157660 hasConcept C67705224 @default.
• W3166157660 hasConcept C86803240 @default.
• W3166157660 hasConcept C95444343 @default.
• W3166157660 hasConceptScore W3166157660C104317684 @default.
• W3166157660 hasConceptScore W3166157660C145059251 @default.
• W3166157660 hasConceptScore W3166157660C153911025 @default.
• W3166157660 hasConceptScore W3166157660C2775893923 @default.
• W3166157660 hasConceptScore W3166157660C2776694085 @default.
• W3166157660 hasConceptScore W3166157660C2778239845 @default.
• W3166157660 hasConceptScore W3166157660C502942594 @default.
• W3166157660 hasConceptScore W3166157660C54355233 @default.
• W3166157660 hasConceptScore W3166157660C55493867 @default.
• W3166157660 hasConceptScore W3166157660C60365752 @default.
• W3166157660 hasConceptScore W3166157660C62112901 @default.
• W3166157660 hasConceptScore W3166157660C62203573 @default.
• W3166157660 hasConceptScore W3166157660C67705224 @default.
• W3166157660 hasConceptScore W3166157660C86803240 @default.
• W3166157660 hasConceptScore W3166157660C95444343 @default.
• W3166157660 hasIssue "13" @default.
• W3166157660 hasLocation W31661576601 @default.
• W3166157660 hasLocation W31661576602 @default.
• W3166157660 hasLocation W31661576603 @default.
• W3166157660 hasOpenAccess W3166157660 @default.
• W3166157660 hasPrimaryLocation W31661576601 @default.
• W3166157660 hasRelatedWork W2782607110 @default.
• W3166157660 hasRelatedWork W2795917193 @default.
• W3166157660 hasRelatedWork W2890741937 @default.
• W3166157660 hasRelatedWork W2954767213 @default.
• W3166157660 hasRelatedWork W3024154810 @default.

• next