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- W3166177718 abstract "To develop a safer immunosuppressant for organ transplantation and autoimmune disease treatment, in this study, several of novel amino alcohol derivatives containing thioether moiety were synthesized with 7-bromo-tetralin-2-one as starting material, and Suzuki coupling reaction and Bucherer-Bergs reaction as key steps. Their activity as sphingosine 1-phosphate receptor type 1 (S1P 1 ) agonists were evaluated by [γ- 35 S] GTP binding assay. Among the thioether substituted compounds, compound 10 showed good activity as S1P 1 agonist at low micromolar concentration (EC50 = 0.698 μmol/L). The result suggested that it has potential activity against autoimmune diseases and immunosuppressant of organ transplantations." @default.
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- W3166177718 date "2021-05-01" @default.
- W3166177718 modified "2023-09-23" @default.
- W3166177718 title "Design, synthesis and biological evaluation as immunosuppressant of amino alcohol derivatives containing thioether" @default.
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- W3166177718 doi "https://doi.org/10.1166/mex.2021.1947" @default.
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