Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166180310> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W3166180310 endingPage "125" @default.
- W3166180310 startingPage "125" @default.
- W3166180310 abstract "125 Background: Accurate clinical staging is crucial to managing gastrointestinal cancer. But 18F-fluorodoxyglucose (FDG) PET/CT has limitations. Targeting fibroblast-activation-protein (FAP) is a newer diagnostic approach for the visualization of tumor stroma, and 68Ga-labeled FAP-inhibitors (68Ga-FAPI) present a promising alternative to 18F-FDG. Purpose: To evaluate the diagnostic efficacy of 68Ga-FAPI PET/CT in the primary and metastatic lesions of gastrointestinal malignancies, compared with 18F-FDG PET/CT.Materials and Methods: Participants with gastric, duodenal and colorectal cancers, who received contemporaneous 18F-FDG and 68Ga-FAPI PET/CT between October 2019 through June 2020, were retrospectively analyzed. 18F-FDG and 68Ga-FAPI uptakes were compared using the Wilcoxon signed-rank test. McNemar’s test was used to compare the diagnostic performance between the two scans. Results: 35 participants (median, 64 years; interquartile range (IQR), 53-68 years; 18 men) were evaluated. In treatment-naive participants (n = 19), 68Ga-FAPI PET/CT upstaged the clinical TNM (tumor-node-metastasis) staging in 4 (21%) participants, compared with 18F-FDG PET/CT. 68Ga-FAPI PET/CT showed a higher tracer uptake in primary lesions (gastric cancer, 12.7 vs. 3.7, P = 0.003; colorectal cancer, 15.9 vs. 7.9, P = 0.03), involved lymph nodes (6.7 vs. 2.4, P < 0.001), bone and visceral metastases (liver-mets: 9.7 vs. 5.2, P < 0.001; peritoneal-mets: 8.4 vs. 3.6, P < 0.001; bone-mets: 4.3 vs. 2.2, P < 0.001; lung-mets: 4.4 vs. 1.9, P = 0.01) than 18F-FDG PET/CT, with higher sensitivities in the detection of primary tumors (100% [19/19] vs. 53% [10/19], P = 0.004), lymph nodes (79% [22/28] vs. 54% [15/28], P < 0.001), bone and visceral metastases (89% [31/35] vs. 57% [20/35], P < 0.001). Conclusions: 68Ga-FAPI PET/CT was superior to 18F-FDG PET/CT in the detection of primary and metastatic lesions in gastric, duodenal, and colorectal cancers, with higher tracer uptakes of most primary and metastatic lesions." @default.
- W3166180310 created "2021-06-22" @default.
- W3166180310 creator A5009857183 @default.
- W3166180310 creator A5012278970 @default.
- W3166180310 creator A5031029049 @default.
- W3166180310 creator A5063331794 @default.
- W3166180310 creator A5080169127 @default.
- W3166180310 date "2021-05-01" @default.
- W3166180310 modified "2023-10-07" @default.
- W3166180310 title "Comparison of 68Ga-FAPI and 18F-FDG uptake in gastric, duodenal, and colorectal cancers" @default.
- W3166180310 hasPublicationYear "2021" @default.
- W3166180310 type Work @default.
- W3166180310 sameAs 3166180310 @default.
- W3166180310 citedByCount "0" @default.
- W3166180310 crossrefType "journal-article" @default.
- W3166180310 hasAuthorship W3166180310A5009857183 @default.
- W3166180310 hasAuthorship W3166180310A5012278970 @default.
- W3166180310 hasAuthorship W3166180310A5031029049 @default.
- W3166180310 hasAuthorship W3166180310A5063331794 @default.
- W3166180310 hasAuthorship W3166180310A5080169127 @default.
- W3166180310 hasConcept C105795698 @default.
- W3166180310 hasConcept C111798993 @default.
- W3166180310 hasConcept C119060515 @default.
- W3166180310 hasConcept C121608353 @default.
- W3166180310 hasConcept C126322002 @default.
- W3166180310 hasConcept C126838900 @default.
- W3166180310 hasConcept C127077266 @default.
- W3166180310 hasConcept C186282968 @default.
- W3166180310 hasConcept C2775842073 @default.
- W3166180310 hasConcept C2780849966 @default.
- W3166180310 hasConcept C2989005 @default.
- W3166180310 hasConcept C33923547 @default.
- W3166180310 hasConcept C526805850 @default.
- W3166180310 hasConcept C71924100 @default.
- W3166180310 hasConceptScore W3166180310C105795698 @default.
- W3166180310 hasConceptScore W3166180310C111798993 @default.
- W3166180310 hasConceptScore W3166180310C119060515 @default.
- W3166180310 hasConceptScore W3166180310C121608353 @default.
- W3166180310 hasConceptScore W3166180310C126322002 @default.
- W3166180310 hasConceptScore W3166180310C126838900 @default.
- W3166180310 hasConceptScore W3166180310C127077266 @default.
- W3166180310 hasConceptScore W3166180310C186282968 @default.
- W3166180310 hasConceptScore W3166180310C2775842073 @default.
- W3166180310 hasConceptScore W3166180310C2780849966 @default.
- W3166180310 hasConceptScore W3166180310C2989005 @default.
- W3166180310 hasConceptScore W3166180310C33923547 @default.
- W3166180310 hasConceptScore W3166180310C526805850 @default.
- W3166180310 hasConceptScore W3166180310C71924100 @default.
- W3166180310 hasLocation W31661803101 @default.
- W3166180310 hasOpenAccess W3166180310 @default.
- W3166180310 hasPrimaryLocation W31661803101 @default.
- W3166180310 hasRelatedWork W130695825 @default.
- W3166180310 hasRelatedWork W2166226643 @default.
- W3166180310 hasRelatedWork W2292433342 @default.
- W3166180310 hasRelatedWork W2319410810 @default.
- W3166180310 hasRelatedWork W2364348303 @default.
- W3166180310 hasRelatedWork W2789665558 @default.
- W3166180310 hasRelatedWork W3014088713 @default.
- W3166180310 hasRelatedWork W3031745930 @default.
- W3166180310 hasRelatedWork W3109525285 @default.
- W3166180310 hasRelatedWork W3153204783 @default.
- W3166180310 hasRelatedWork W3164206095 @default.
- W3166180310 hasRelatedWork W3168005648 @default.
- W3166180310 hasRelatedWork W3169770153 @default.
- W3166180310 hasRelatedWork W3184932247 @default.
- W3166180310 hasRelatedWork W3185979786 @default.
- W3166180310 hasRelatedWork W3188283715 @default.
- W3166180310 hasRelatedWork W3199726744 @default.
- W3166180310 hasRelatedWork W3205608405 @default.
- W3166180310 hasRelatedWork W3207353663 @default.
- W3166180310 hasRelatedWork W4225607496 @default.
- W3166180310 hasVolume "62" @default.
- W3166180310 isParatext "false" @default.
- W3166180310 isRetracted "false" @default.
- W3166180310 magId "3166180310" @default.
- W3166180310 workType "article" @default.