Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166184109> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3166184109 endingPage "251" @default.
- W3166184109 startingPage "250" @default.
- W3166184109 abstract "Left ventricular (LV) replacement myocardial fibrosis has been described in MVP. We aimed at assessing the prevalence, pathophysiological and prognostic significance of LV replacement myocardial fibrosis through late gadolinium enhancement (LGE) by cardiac magnetic resonance (CMR) in MVP Four hundred patients (53 ± 15 years, 55% male) with MVP underwent echocardiography and CMR. Correlates of replacement myocardial fibrosis (LGE + ), influence of MR degree, and ventricular arrhythmia were assessed. The primary outcome was a composite of cardiovascular events. LGE+ was observed in 110 patients (28%; 91 myocardial wall including 71 basal inferolateral wall, 29 papillary muscle). LGE+ prevalence was 13% in trace-mild MR, 28% in moderate and 37% in severe MR, and was associated with specific features of mitral valve apparatus, more dilated LV and more frequent ventricular arrhythmias (45 vs. 26%, P < 0.0001). In trace-mild MR, despite the absence of significant volume overload, abnormal LV dilatation was observed in 16% of patients and ventricular arrhythmia in 25%. Correlates of LGE+ in multivariable analysis were LV mass [OR 1.01, 95% CI (1.002–1.017), P = 0.009] and moderate-severe MR [OR: 2.28, 95% CI (1.21–4.31), P = 0.011]. LGE+ was associated with worse 4-year cardiovascular event-free survival (49.6 ± 11.7 in LGE+ vs. 73.3 ± 6.5% in LGE-, P < 0.0001). In a stepwise multivariable Cox model, MR volume and LGE+ [HR: 2.6 (1.4–4.9), P = 0.002] were associated with poor outcome (Fig. 1). LV replacement myocardial fibrosis is frequent in patients with MVP, is associated with mitral valve apparatus alteration, more dilated LV, MR grade, ventricular arrhythmia, and is independently associated with cardiovascular events. These findings suggest a MVP-related myocardial disease. Finally, CMR provides additional information to echocardiography in MVP." @default.
- W3166184109 created "2021-06-22" @default.
- W3166184109 creator A5017622466 @default.
- W3166184109 creator A5039379911 @default.
- W3166184109 creator A5050357586 @default.
- W3166184109 creator A5054869764 @default.
- W3166184109 creator A5058491810 @default.
- W3166184109 creator A5068621143 @default.
- W3166184109 creator A5071935586 @default.
- W3166184109 creator A5076141799 @default.
- W3166184109 creator A5078873342 @default.
- W3166184109 creator A5087165255 @default.
- W3166184109 date "2021-06-01" @default.
- W3166184109 modified "2023-10-15" @default.
- W3166184109 title "Replacement myocardial fibrosis in patients with mitral valve prolapse. Relation to mitral regurgitation, ventricular remodeling and arrhythmia" @default.
- W3166184109 doi "https://doi.org/10.1016/j.acvdsp.2021.04.028" @default.
- W3166184109 hasPublicationYear "2021" @default.
- W3166184109 type Work @default.
- W3166184109 sameAs 3166184109 @default.
- W3166184109 citedByCount "0" @default.
- W3166184109 crossrefType "journal-article" @default.
- W3166184109 hasAuthorship W3166184109A5017622466 @default.
- W3166184109 hasAuthorship W3166184109A5039379911 @default.
- W3166184109 hasAuthorship W3166184109A5050357586 @default.
- W3166184109 hasAuthorship W3166184109A5054869764 @default.
- W3166184109 hasAuthorship W3166184109A5058491810 @default.
- W3166184109 hasAuthorship W3166184109A5068621143 @default.
- W3166184109 hasAuthorship W3166184109A5071935586 @default.
- W3166184109 hasAuthorship W3166184109A5076141799 @default.
- W3166184109 hasAuthorship W3166184109A5078873342 @default.
- W3166184109 hasAuthorship W3166184109A5087165255 @default.
- W3166184109 hasBestOaLocation W31661841091 @default.
- W3166184109 hasConcept C126322002 @default.
- W3166184109 hasConcept C126838900 @default.
- W3166184109 hasConcept C143409427 @default.
- W3166184109 hasConcept C164705383 @default.
- W3166184109 hasConcept C24595384 @default.
- W3166184109 hasConcept C2775854548 @default.
- W3166184109 hasConcept C2776008845 @default.
- W3166184109 hasConcept C2777543888 @default.
- W3166184109 hasConcept C2778198053 @default.
- W3166184109 hasConcept C2780559512 @default.
- W3166184109 hasConcept C2781030672 @default.
- W3166184109 hasConcept C2993373945 @default.
- W3166184109 hasConcept C3018763269 @default.
- W3166184109 hasConcept C71924100 @default.
- W3166184109 hasConceptScore W3166184109C126322002 @default.
- W3166184109 hasConceptScore W3166184109C126838900 @default.
- W3166184109 hasConceptScore W3166184109C143409427 @default.
- W3166184109 hasConceptScore W3166184109C164705383 @default.
- W3166184109 hasConceptScore W3166184109C24595384 @default.
- W3166184109 hasConceptScore W3166184109C2775854548 @default.
- W3166184109 hasConceptScore W3166184109C2776008845 @default.
- W3166184109 hasConceptScore W3166184109C2777543888 @default.
- W3166184109 hasConceptScore W3166184109C2778198053 @default.
- W3166184109 hasConceptScore W3166184109C2780559512 @default.
- W3166184109 hasConceptScore W3166184109C2781030672 @default.
- W3166184109 hasConceptScore W3166184109C2993373945 @default.
- W3166184109 hasConceptScore W3166184109C3018763269 @default.
- W3166184109 hasConceptScore W3166184109C71924100 @default.
- W3166184109 hasIssue "3" @default.
- W3166184109 hasLocation W31661841091 @default.
- W3166184109 hasOpenAccess W3166184109 @default.
- W3166184109 hasPrimaryLocation W31661841091 @default.
- W3166184109 hasRelatedWork W1969122194 @default.
- W3166184109 hasRelatedWork W1999649910 @default.
- W3166184109 hasRelatedWork W2047359258 @default.
- W3166184109 hasRelatedWork W2096589181 @default.
- W3166184109 hasRelatedWork W2344842521 @default.
- W3166184109 hasRelatedWork W2404582479 @default.
- W3166184109 hasRelatedWork W2417870057 @default.
- W3166184109 hasRelatedWork W2999890088 @default.
- W3166184109 hasRelatedWork W3134205874 @default.
- W3166184109 hasRelatedWork W4323363286 @default.
- W3166184109 hasVolume "13" @default.
- W3166184109 isParatext "false" @default.
- W3166184109 isRetracted "false" @default.
- W3166184109 magId "3166184109" @default.
- W3166184109 workType "article" @default.