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- W3166187930 abstract "Background The Zinc fingers and homeoboxes 2(Zhx2) gene has been identified as being responsible for the mouse Hyplip2 trait characterized by hyperlipidemia and atherosclerosis. This finding is supported by a recent human GWAS study identifying ZHX2 as an important risk factor for carotid intima media thickness, a measure of subclinical atherosclerosis. Mice with mutated Zhx2 incur less cardiovascular damage from a high-fat diet than wildtype mice. Objective To explore the role of Zhx2 on lipid metabolism and homeostasis, as well as its impact on cardiovascular and hepatic health. Methods Wild-type and Zhx2-mutant mice were fed either a control or high-fat (15%) diet for 8 weeks. Body weight was measured and serum was collected during this period, and tissues were collected post-sacrifice. Quantitative RT-PCR analysis was performed to assess gene expression. Results Mice with low Zhx2 levels have elevated serum ALT levels, increased hepatic AFP mRNA, and elevated liver pathology and lipid accumulation. Additionally, Lpl, Elovl3, and Cyp8B1, genes involved in cholesterol/lipid metabolism, were identified as Zhx2 targets. Conclusions These data indicate that reduced Zhx2 levels may be cardioprotective but at the same time lead to increased liver damage in mice on a high-fat diet. Further studies will investigate the role of Zhx2 in human cardiovascular and liver disease. This research is supported by PHS Grants DK074816 and RR021954 from the NIH." @default.
- W3166187930 created "2021-06-22" @default.
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- W3166187930 date "2013-04-01" @default.
- W3166187930 modified "2023-10-16" @default.
- W3166187930 title "Zhx2 and the balance between cardiovascular and hepatic health" @default.
- W3166187930 doi "https://doi.org/10.1096/fasebj.27.1_supplement.794.14" @default.
- W3166187930 hasPublicationYear "2013" @default.
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