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• W3166204582 abstract "Alterations in activity and connectivity of brain circuits implicated in emotion processing and emotion regulation have been observed during resting-state for different clinical phases of bipolar disorders (BD), but longitudinal investigations across different mood states in the same patients are still rare. Furthermore, measuring dynamics of functional connectivity patterns offers a powerful method to explore changes in the brain's intrinsic functional organization across mood states. We used a novel co-activation pattern (CAP) analysis to explore the dynamics of amygdala connectivity at rest in a cohort of 20 BD patients prospectively followed-up and scanned across distinct mood states: euthymia (20 patients; 39 sessions), depression (12 patients; 18 sessions), or mania/hypomania (14 patients; 18 sessions). We compared them to 41 healthy controls scanned once or twice (55 sessions). We characterized temporal aspects of dynamic fluctuations in amygdala connectivity over the whole brain as a function of current mood. We identified six distinct networks describing amygdala connectivity, among which an interoceptive-sensorimotor CAP exhibited more frequent occurrences during hypomania compared to other mood states, and predicted more severe symptoms of irritability and motor agitation. In contrast, a default-mode CAP exhibited more frequent occurrences during depression compared to other mood states and compared to controls, with a positive association with depression severity. Our results reveal distinctive interactions between amygdala and distributed brain networks in different mood states, and foster research on interoception and default-mode systems especially during the manic and depressive phase, respectively. Our study also demonstrates the benefits of assessing brain dynamics in BD." @default.
• W3166204582 created "2021-06-22" @default.
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• W3166204582 date "2021-06-07" @default.
• W3166204582 modified "2023-10-17" @default.
• W3166204582 title "Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states" @default.
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• W3166204582 doi "https://doi.org/10.1038/s41386-021-01038-x" @default.
• W3166204582 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8280117" @default.
• W3166204582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34099869" @default.
• W3166204582 hasPublicationYear "2021" @default.
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