Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166223795> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3166223795 endingPage "e21020" @default.
- W3166223795 startingPage "e21020" @default.
- W3166223795 abstract "e21020 Background: Here we assessed TMB level, PD-L1 expression, and their correlation in 9649 Chinese NSCLC patients with or without EGFR mutation, and different subtypes of EGFR mutations, to find out the underlying mechanisms that different outcomes of ICI for EGFR wild type and EGFR mutation NSCLC patients, and the possibility of ICI therapy for NSCLC patients of different EGFR mutation subtypes. Methods: Tumor tissue samples of 9649 NSCLC patients were collected from Janary 2018, expression of PD-L1 were detected by using Dako PD-L1 IHC 22C3 pharmDx, Tumor Proportion Score (TPS) was used to determine expression of PD-L1. Gene mutation was detected by means of next generation sequencing (NGS). Performed Whole-Exome Sequencing (WES) on 70 tissue samples and corresponding White Blood Cells (WBCs) as matched control. Other samples were detected with panel covering whole exon regions of 733 cancer related genes. All these detections were performed in a College of American Pathologists (CAP)-certified and Clinical Laboratory Improvement Amendments (CLIA)-accredited lab for gene mutation analysis (3D Medicines Inc.,Shanghai, China). Statistical analysis was performed using GraphPad Prism (version 7.01) and SPSS version 21.0 (SPSS,Inc.). Results: Results showed that the proportion of EGFR mutation in Chinese patients with NSCLC was 51.3%, and the proportion of EGFR mutation subtypes were 42.6% L858R, 39.5% exon 19del, 2.3% exon 20in, 4.3% T790M. These samples were divided into different groups according to EGFR mutation, both WES based and panel-based results showed that EGFR wild type group displayed higher TMB level than EGFR mutation group (P < 0.05). However, except for exon 19del, L858R, exon 20in, no significant differences were found between wild type and other EGFR mutation subtypes. Furthermore, results of IHC revealed that, higher proportion of strong positive PD-L1 expression (TPS≥50) were found in EGFR wild type than exon 19del, L858R and exon 20in, no significant correlation was found between TMB level and PD-L1 expression. Conclusions: EGFR mutations account for half of Chinese NSCLC patients. The biomarkers of immune checkpoint inhibitors (such as TMB and PD-L1) are different in various EGFR mutation subtypes, which may indicate that for some NSCLC patients with EGFR mutation subtypes, they may also respond to ICI treatment as wild-type." @default.
- W3166223795 created "2021-06-22" @default.
- W3166223795 creator A5001199287 @default.
- W3166223795 creator A5004648803 @default.
- W3166223795 creator A5024830909 @default.
- W3166223795 creator A5030488812 @default.
- W3166223795 creator A5063206909 @default.
- W3166223795 creator A5072315951 @default.
- W3166223795 creator A5086940264 @default.
- W3166223795 creator A5088640614 @default.
- W3166223795 date "2021-05-20" @default.
- W3166223795 modified "2023-10-16" @default.
- W3166223795 title "Exploring the applicability of immunotherapy in different EGFR mutation subgroups based on data analysis of 9,659 Chinese patients with NSCLC." @default.
- W3166223795 doi "https://doi.org/10.1200/jco.2021.39.15_suppl.e21020" @default.
- W3166223795 hasPublicationYear "2021" @default.
- W3166223795 type Work @default.
- W3166223795 sameAs 3166223795 @default.
- W3166223795 citedByCount "0" @default.
- W3166223795 crossrefType "journal-article" @default.
- W3166223795 hasAuthorship W3166223795A5001199287 @default.
- W3166223795 hasAuthorship W3166223795A5004648803 @default.
- W3166223795 hasAuthorship W3166223795A5024830909 @default.
- W3166223795 hasAuthorship W3166223795A5030488812 @default.
- W3166223795 hasAuthorship W3166223795A5063206909 @default.
- W3166223795 hasAuthorship W3166223795A5072315951 @default.
- W3166223795 hasAuthorship W3166223795A5086940264 @default.
- W3166223795 hasAuthorship W3166223795A5088640614 @default.
- W3166223795 hasConcept C104317684 @default.
- W3166223795 hasConcept C121608353 @default.
- W3166223795 hasConcept C126322002 @default.
- W3166223795 hasConcept C143998085 @default.
- W3166223795 hasConcept C163565370 @default.
- W3166223795 hasConcept C2775999482 @default.
- W3166223795 hasConcept C2776256026 @default.
- W3166223795 hasConcept C2777930144 @default.
- W3166223795 hasConcept C2779177807 @default.
- W3166223795 hasConcept C2781182431 @default.
- W3166223795 hasConcept C2994225774 @default.
- W3166223795 hasConcept C36823959 @default.
- W3166223795 hasConcept C501734568 @default.
- W3166223795 hasConcept C54355233 @default.
- W3166223795 hasConcept C71924100 @default.
- W3166223795 hasConcept C81729549 @default.
- W3166223795 hasConcept C86803240 @default.
- W3166223795 hasConceptScore W3166223795C104317684 @default.
- W3166223795 hasConceptScore W3166223795C121608353 @default.
- W3166223795 hasConceptScore W3166223795C126322002 @default.
- W3166223795 hasConceptScore W3166223795C143998085 @default.
- W3166223795 hasConceptScore W3166223795C163565370 @default.
- W3166223795 hasConceptScore W3166223795C2775999482 @default.
- W3166223795 hasConceptScore W3166223795C2776256026 @default.
- W3166223795 hasConceptScore W3166223795C2777930144 @default.
- W3166223795 hasConceptScore W3166223795C2779177807 @default.
- W3166223795 hasConceptScore W3166223795C2781182431 @default.
- W3166223795 hasConceptScore W3166223795C2994225774 @default.
- W3166223795 hasConceptScore W3166223795C36823959 @default.
- W3166223795 hasConceptScore W3166223795C501734568 @default.
- W3166223795 hasConceptScore W3166223795C54355233 @default.
- W3166223795 hasConceptScore W3166223795C71924100 @default.
- W3166223795 hasConceptScore W3166223795C81729549 @default.
- W3166223795 hasConceptScore W3166223795C86803240 @default.
- W3166223795 hasIssue "15_suppl" @default.
- W3166223795 hasLocation W31662237951 @default.
- W3166223795 hasOpenAccess W3166223795 @default.
- W3166223795 hasPrimaryLocation W31662237951 @default.
- W3166223795 hasRelatedWork W2007661090 @default.
- W3166223795 hasRelatedWork W2024276281 @default.
- W3166223795 hasRelatedWork W2144709843 @default.
- W3166223795 hasRelatedWork W2363458739 @default.
- W3166223795 hasRelatedWork W2369479061 @default.
- W3166223795 hasRelatedWork W2549506770 @default.
- W3166223795 hasRelatedWork W2776113720 @default.
- W3166223795 hasRelatedWork W2972608234 @default.
- W3166223795 hasRelatedWork W3031478545 @default.
- W3166223795 hasRelatedWork W3133995256 @default.
- W3166223795 hasVolume "39" @default.
- W3166223795 isParatext "false" @default.
- W3166223795 isRetracted "false" @default.
- W3166223795 magId "3166223795" @default.
- W3166223795 workType "article" @default.