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- W3166248497 abstract "Abstract Owing to species-specific differences in liver pathways, in vitro human liver models are utilized for elucidating mechanisms underlying disease pathogenesis, drug development, and regenerative medicine. To mitigate limitations with de-differentiated cultures, bioengineers have developed advanced techniques/platforms, including micropatterned cocultures, spheroids/organoids, bioprinting, and microfluidic devices, for perfusing cell cultures and liver slices. Such techniques improve mature functions and culture lifetime of primary and stem-cell human liver cells. Furthermore, bioengineered liver models display several features of liver diseases including infections with pathogens (e.g., malaria, hepatitis C/B viruses, Zika, dengue, yellow fever), alcoholic/nonalcoholic fatty liver disease, and cancer. Here, we discuss features of bioengineered human liver models, their uses for modeling aforementioned diseases, and how such models are being augmented/adapted for fabricating implantable human liver tissues for clinical therapy. Ultimately, continued advances in bioengineered human liver models have the potential to aid the development of novel, safe, and efficacious therapies for liver disease." @default.
- W3166248497 created "2021-06-22" @default.
- W3166248497 creator A5022695150 @default.
- W3166248497 creator A5036799597 @default.
- W3166248497 date "2021-06-17" @default.
- W3166248497 modified "2023-09-25" @default.
- W3166248497 title "Bioengineered Liver Models for Investigating Disease Pathogenesis and Regenerative Medicine" @default.
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