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- W3166276947 abstract "We have reviewed current understanding of ischemic brain damage and the main therapeutic approaches. Pathological factors affecting the survival of neurons and glial cells in the focus of ischemia are outlined: depolarization, cytotoxic and vasogenic edema, calcium overload, excitotoxicity, inflammation, free radical damage. Effective and rapid reperfusion significantly improves patient’s survival and functional outcomes, but other approaches to brain infarction treatment did not approve their effectiveness in large clinical trials. Dozens of drugs (neuroprotectors) are being studied in order to compensate isolated pathological brain ischemia pathways and to increase cellular survival, but they were ineffective in large clinical trials.The reason for the ineffectiveness of neuroprotective drugs may be a lack of understanding of the drug targets real importance. Many drugs that have shown promising results in preclinical studies have not been studied in large clinical trials until now. Additional pathogenetic mechanisms revealed in the last decade expand our knowledge about the brain infarction and may become promising directions for the development of new therapeutic approaches." @default.
- W3166276947 created "2021-06-22" @default.
- W3166276947 creator A5013522858 @default.
- W3166276947 creator A5016216473 @default.
- W3166276947 creator A5026083799 @default.
- W3166276947 date "2021-06-13" @default.
- W3166276947 modified "2023-10-04" @default.
- W3166276947 title "Brain acute ischemia mechanisms: implications to experimental and clinical treatment" @default.
- W3166276947 cites W14748109 @default.
- W3166276947 cites W1494319831 @default.
- W3166276947 cites W1513883393 @default.
- W3166276947 cites W1571985114 @default.
- W3166276947 cites W1695543549 @default.
- W3166276947 cites W186716551 @default.
- W3166276947 cites W1933215500 @default.
- W3166276947 cites W1972468341 @default.
- W3166276947 cites W1974294728 @default.
- W3166276947 cites W1975915247 @default.
- W3166276947 cites W1980311878 @default.
- W3166276947 cites W1982289718 @default.
- W3166276947 cites W1985538633 @default.
- W3166276947 cites W1986449271 @default.
- W3166276947 cites W1988100193 @default.
- W3166276947 cites W1990527302 @default.
- W3166276947 cites W1994413017 @default.
- W3166276947 cites W1994682771 @default.
- W3166276947 cites W1995037165 @default.
- W3166276947 cites W2006558385 @default.
- W3166276947 cites W2007076123 @default.
- W3166276947 cites W2010980945 @default.
- W3166276947 cites W2016646182 @default.
- W3166276947 cites W2023749167 @default.
- W3166276947 cites W2026741596 @default.
- W3166276947 cites W2028151610 @default.
- W3166276947 cites W2034861293 @default.
- W3166276947 cites W2040389158 @default.
- W3166276947 cites W2041477377 @default.
- W3166276947 cites W2045445343 @default.
- W3166276947 cites W2048047884 @default.
- W3166276947 cites W2048903425 @default.
- W3166276947 cites W2050190084 @default.
- W3166276947 cites W2065957706 @default.
- W3166276947 cites W2069546586 @default.
- W3166276947 cites W2069634387 @default.
- W3166276947 cites W2070980267 @default.
- W3166276947 cites W2072853625 @default.
- W3166276947 cites W2073923875 @default.
- W3166276947 cites W2078779087 @default.
- W3166276947 cites W2080203024 @default.
- W3166276947 cites W2080901528 @default.
- W3166276947 cites W2082879602 @default.
- W3166276947 cites W2083004303 @default.
- W3166276947 cites W2083581277 @default.
- W3166276947 cites W2089592952 @default.
- W3166276947 cites W2090095365 @default.
- W3166276947 cites W2093580567 @default.
- W3166276947 cites W2094869269 @default.
- W3166276947 cites W2096118264 @default.
- W3166276947 cites W2103525815 @default.
- W3166276947 cites W2106274476 @default.
- W3166276947 cites W2113608265 @default.
- W3166276947 cites W2114604887 @default.
- W3166276947 cites W2115772647 @default.
- W3166276947 cites W2118901526 @default.
- W3166276947 cites W2124335748 @default.
- W3166276947 cites W2124743446 @default.
- W3166276947 cites W2130190017 @default.
- W3166276947 cites W2134366767 @default.
- W3166276947 cites W2136030857 @default.
- W3166276947 cites W2136280619 @default.
- W3166276947 cites W2137653998 @default.
- W3166276947 cites W2140175924 @default.
- W3166276947 cites W2141683458 @default.
- W3166276947 cites W2146336916 @default.
- W3166276947 cites W2159103481 @default.
- W3166276947 cites W2159744102 @default.
- W3166276947 cites W2161296178 @default.
- W3166276947 cites W2162580040 @default.
- W3166276947 cites W2164224870 @default.
- W3166276947 cites W2164394064 @default.
- W3166276947 cites W2165064047 @default.
- W3166276947 cites W2168109100 @default.
- W3166276947 cites W2174687859 @default.
- W3166276947 cites W2199978366 @default.
- W3166276947 cites W2345329114 @default.
- W3166276947 cites W2345409531 @default.
- W3166276947 cites W2347147930 @default.
- W3166276947 cites W2351673993 @default.
- W3166276947 cites W2430451014 @default.
- W3166276947 cites W2460289322 @default.
- W3166276947 cites W2508320459 @default.
- W3166276947 cites W2520095852 @default.
- W3166276947 cites W2542414179 @default.
- W3166276947 cites W2563063938 @default.
- W3166276947 cites W2581649270 @default.
- W3166276947 cites W2590458460 @default.
- W3166276947 cites W2602576689 @default.
- W3166276947 cites W2606004110 @default.