Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166301930> ?p ?o ?g. }
- W3166301930 endingPage "6418" @default.
- W3166301930 startingPage "6418" @default.
- W3166301930 abstract "Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in survivors. TBI induces multiple secondary injuries, including neuroinflammation, disruption of the blood–brain barrier (BBB), and brain edema. Despite these emergent conditions, current therapies for TBI are limited or insufficient in some cases. Although several candidate drugs exerted beneficial effects in TBI animal models, most of them failed to show significant effects in clinical trials. Multiple studies have suggested that astrocytes play a key role in the pathogenesis of TBI. Increased reactive astrocytes and astrocyte-derived factors are commonly observed in both TBI patients and experimental animal models. Astrocytes have beneficial and detrimental effects on TBI, including promotion and restriction of neurogenesis and synaptogenesis, acceleration and suppression of neuroinflammation, and disruption and repair of the BBB via multiple bioactive factors. Additionally, astrocytic aquaporin-4 is involved in the formation of cytotoxic edema. Thus, astrocytes are attractive targets for novel therapeutic drugs for TBI, although astrocyte-targeting drugs have not yet been developed. This article reviews recent observations of the roles of astrocytes and expected astrocyte-targeting drugs in TBI." @default.
- W3166301930 created "2021-06-22" @default.
- W3166301930 creator A5039434669 @default.
- W3166301930 creator A5091267274 @default.
- W3166301930 date "2021-06-15" @default.
- W3166301930 modified "2023-10-12" @default.
- W3166301930 title "Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury" @default.
- W3166301930 cites W1197243746 @default.
- W3166301930 cites W1480468820 @default.
- W3166301930 cites W1510059371 @default.
- W3166301930 cites W1519585367 @default.
- W3166301930 cites W172954148 @default.
- W3166301930 cites W1818228426 @default.
- W3166301930 cites W1833381290 @default.
- W3166301930 cites W1848568713 @default.
- W3166301930 cites W1972210292 @default.
- W3166301930 cites W1979916433 @default.
- W3166301930 cites W1982685163 @default.
- W3166301930 cites W1986764072 @default.
- W3166301930 cites W1998419839 @default.
- W3166301930 cites W1999890575 @default.
- W3166301930 cites W2001327092 @default.
- W3166301930 cites W2005401338 @default.
- W3166301930 cites W2005830956 @default.
- W3166301930 cites W2007701595 @default.
- W3166301930 cites W2011398156 @default.
- W3166301930 cites W2015551349 @default.
- W3166301930 cites W2019610319 @default.
- W3166301930 cites W2020030788 @default.
- W3166301930 cites W2022621268 @default.
- W3166301930 cites W2023250693 @default.
- W3166301930 cites W2025849462 @default.
- W3166301930 cites W2028662192 @default.
- W3166301930 cites W2034035188 @default.
- W3166301930 cites W2036924440 @default.
- W3166301930 cites W2043526429 @default.
- W3166301930 cites W2044692802 @default.
- W3166301930 cites W2046037876 @default.
- W3166301930 cites W2052172724 @default.
- W3166301930 cites W2062004077 @default.
- W3166301930 cites W2064839996 @default.
- W3166301930 cites W2065518048 @default.
- W3166301930 cites W2066865589 @default.
- W3166301930 cites W2073260128 @default.
- W3166301930 cites W2079456489 @default.
- W3166301930 cites W2082920313 @default.
- W3166301930 cites W2083581277 @default.
- W3166301930 cites W2091296234 @default.
- W3166301930 cites W2092814867 @default.
- W3166301930 cites W2098893487 @default.
- W3166301930 cites W2103037576 @default.
- W3166301930 cites W2108794373 @default.
- W3166301930 cites W2112462557 @default.
- W3166301930 cites W2121860798 @default.
- W3166301930 cites W2124892998 @default.
- W3166301930 cites W2130198578 @default.
- W3166301930 cites W2134186952 @default.
- W3166301930 cites W2135014287 @default.
- W3166301930 cites W2145695478 @default.
- W3166301930 cites W2157887795 @default.
- W3166301930 cites W2159026586 @default.
- W3166301930 cites W2166851454 @default.
- W3166301930 cites W2168457371 @default.
- W3166301930 cites W2199142894 @default.
- W3166301930 cites W2292924020 @default.
- W3166301930 cites W2323636201 @default.
- W3166301930 cites W2327714939 @default.
- W3166301930 cites W2343601674 @default.
- W3166301930 cites W2412971846 @default.
- W3166301930 cites W2413506410 @default.
- W3166301930 cites W2488581011 @default.
- W3166301930 cites W2500109500 @default.
- W3166301930 cites W2560014610 @default.
- W3166301930 cites W2586518645 @default.
- W3166301930 cites W2613830934 @default.
- W3166301930 cites W2620694208 @default.
- W3166301930 cites W2727957981 @default.
- W3166301930 cites W2728577001 @default.
- W3166301930 cites W2734710590 @default.
- W3166301930 cites W2739211306 @default.
- W3166301930 cites W2749056675 @default.
- W3166301930 cites W2754554955 @default.
- W3166301930 cites W2755388034 @default.
- W3166301930 cites W2757065242 @default.
- W3166301930 cites W2765953433 @default.
- W3166301930 cites W2770237093 @default.
- W3166301930 cites W2770590892 @default.
- W3166301930 cites W2784015117 @default.
- W3166301930 cites W2788807220 @default.
- W3166301930 cites W2790955930 @default.
- W3166301930 cites W2796054699 @default.
- W3166301930 cites W2804503506 @default.
- W3166301930 cites W2807705689 @default.
- W3166301930 cites W2886166995 @default.
- W3166301930 cites W2887138305 @default.
- W3166301930 cites W2888922379 @default.
- W3166301930 cites W2891402596 @default.
- W3166301930 cites W2899673666 @default.