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- W3166350060 abstract "ABSTRACT The selectivity filter (SF) determines which ions are efficiently conducted through ion channel pores. NaK is a non-selective cation channel that conducts Na + and K + with equal efficiency. Crystal structures of NaK suggested a rigid SF structure, but later solid-state NMR and MD simulations questioned this interpretation. Here, we use solution NMR to characterize how bound Na + vs. K + affects NaK SF structure and dynamics. We find that the extracellular end of the SF is flexible on the ps-ns timescale regardless of bound ion. On a slower timescale, we observe a structural change between the Na + and K + -bound states, accompanied by increased structural heterogeneity in Na + . We also show direct evidence that the SF structure is communicated to the pore via I88 on the M2 helix. These results support a dynamic SF with multiple conformations involved in non-selective conduction. Our data also demonstrate allosteric coupling between the SF and pore-lining helices in a non-selective cation channel that is analogous to the allosteric coupling previously demonstrated for K + -selective channels, supporting the generality of this model." @default.
- W3166350060 created "2021-06-22" @default.
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- W3166350060 date "2021-06-16" @default.
- W3166350060 modified "2023-09-25" @default.
- W3166350060 title "Ion-dependent structure, dynamics, and allosteric coupling in a non-selective cation channel" @default.
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- W3166350060 doi "https://doi.org/10.1101/2021.06.16.448691" @default.
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