Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166355756> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3166355756 abstract "Abstract The neuroplastic mechanism of sex reversal in the fish brain remains unclear due to the difficulty in identifying the key neurons involved. Mozambique tilapia show different reproductive behaviours between sexes; males build circular breeding nests while females hold and brood fertilized eggs in their mouth. In tilapia, gonadotropin-releasing hormone 3 (GnRH3) neurons, located in the terminal nerve, regulate male reproductive behaviour. Mature males have more GnRH3 neurons than mature females, and these neurons have been indicated to play a key role in the androgen-induced female-to-male sex reversal of the brain. We aimed to elucidate the signalling pathway involved in the androgen-induced increase in GnRH3 neurons in mature female tilapia. Applying inhibitors to organotypic cultures of brain slices, we showed that the insulin-like growth factor (IGF)-1 receptor (IGF-1R)/PI3K/AKT/mTOR pathway contributed to the androgen-induced increase in GnRH3 neurons. The involvement of IGF-1 and IGF-1R in 11-ketotestosterone (11-KT)-induced development of GnRH3 neurons was supported by an increase in Igf-1 mRNA shortly after 11-KT treatment, the increase of GnRH3 neurons after IGF-1 treatment and the expression of IGF-1 in GnRH3 neurons. Our findings highlight the involvement of IGF-1 and its downstream signalling pathway in the sex reversal of the tilapia brain." @default.
- W3166355756 created "2021-06-22" @default.
- W3166355756 creator A5002254556 @default.
- W3166355756 creator A5030236791 @default.
- W3166355756 creator A5033591657 @default.
- W3166355756 creator A5047520703 @default.
- W3166355756 creator A5056551591 @default.
- W3166355756 creator A5071023264 @default.
- W3166355756 creator A5080576164 @default.
- W3166355756 creator A5080639868 @default.
- W3166355756 date "2021-06-15" @default.
- W3166355756 modified "2023-10-01" @default.
- W3166355756 title "Involvement of IGF-1R-PI3K-AKT-mTOR Pathway in Increased Number of GnRH3 Neurons During Androgen-induced Sex Reversal of the Brain in Female Tilapia" @default.
- W3166355756 doi "https://doi.org/10.21203/rs.3.rs-601252/v1" @default.
- W3166355756 hasPublicationYear "2021" @default.
- W3166355756 type Work @default.
- W3166355756 sameAs 3166355756 @default.
- W3166355756 citedByCount "0" @default.
- W3166355756 crossrefType "posted-content" @default.
- W3166355756 hasAuthorship W3166355756A5002254556 @default.
- W3166355756 hasAuthorship W3166355756A5030236791 @default.
- W3166355756 hasAuthorship W3166355756A5033591657 @default.
- W3166355756 hasAuthorship W3166355756A5047520703 @default.
- W3166355756 hasAuthorship W3166355756A5056551591 @default.
- W3166355756 hasAuthorship W3166355756A5071023264 @default.
- W3166355756 hasAuthorship W3166355756A5080576164 @default.
- W3166355756 hasAuthorship W3166355756A5080639868 @default.
- W3166355756 hasBestOaLocation W31663557561 @default.
- W3166355756 hasConcept C126322002 @default.
- W3166355756 hasConcept C134018914 @default.
- W3166355756 hasConcept C146819174 @default.
- W3166355756 hasConcept C169760540 @default.
- W3166355756 hasConcept C2777911890 @default.
- W3166355756 hasConcept C2778575703 @default.
- W3166355756 hasConcept C2778894405 @default.
- W3166355756 hasConcept C2779286987 @default.
- W3166355756 hasConcept C2909208804 @default.
- W3166355756 hasConcept C505870484 @default.
- W3166355756 hasConcept C62478195 @default.
- W3166355756 hasConcept C71315377 @default.
- W3166355756 hasConcept C71924100 @default.
- W3166355756 hasConcept C75217442 @default.
- W3166355756 hasConcept C86554907 @default.
- W3166355756 hasConcept C86803240 @default.
- W3166355756 hasConcept C95444343 @default.
- W3166355756 hasConceptScore W3166355756C126322002 @default.
- W3166355756 hasConceptScore W3166355756C134018914 @default.
- W3166355756 hasConceptScore W3166355756C146819174 @default.
- W3166355756 hasConceptScore W3166355756C169760540 @default.
- W3166355756 hasConceptScore W3166355756C2777911890 @default.
- W3166355756 hasConceptScore W3166355756C2778575703 @default.
- W3166355756 hasConceptScore W3166355756C2778894405 @default.
- W3166355756 hasConceptScore W3166355756C2779286987 @default.
- W3166355756 hasConceptScore W3166355756C2909208804 @default.
- W3166355756 hasConceptScore W3166355756C505870484 @default.
- W3166355756 hasConceptScore W3166355756C62478195 @default.
- W3166355756 hasConceptScore W3166355756C71315377 @default.
- W3166355756 hasConceptScore W3166355756C71924100 @default.
- W3166355756 hasConceptScore W3166355756C75217442 @default.
- W3166355756 hasConceptScore W3166355756C86554907 @default.
- W3166355756 hasConceptScore W3166355756C86803240 @default.
- W3166355756 hasConceptScore W3166355756C95444343 @default.
- W3166355756 hasLocation W31663557561 @default.
- W3166355756 hasLocation W31663557562 @default.
- W3166355756 hasOpenAccess W3166355756 @default.
- W3166355756 hasPrimaryLocation W31663557561 @default.
- W3166355756 hasRelatedWork W1973988117 @default.
- W3166355756 hasRelatedWork W2026333686 @default.
- W3166355756 hasRelatedWork W2027690364 @default.
- W3166355756 hasRelatedWork W2034250624 @default.
- W3166355756 hasRelatedWork W2063133456 @default.
- W3166355756 hasRelatedWork W2074431763 @default.
- W3166355756 hasRelatedWork W2078538260 @default.
- W3166355756 hasRelatedWork W2114291118 @default.
- W3166355756 hasRelatedWork W2525536472 @default.
- W3166355756 hasRelatedWork W3093395452 @default.
- W3166355756 isParatext "false" @default.
- W3166355756 isRetracted "false" @default.
- W3166355756 magId "3166355756" @default.
- W3166355756 workType "article" @default.