FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166362886> ?p ?o ?g. }

• W3166362886 abstract "Sepsis is a common life-threatening disease in the intensive care unit (ICU) that is usually treated empirically without pathogen identification. As a non-invasive and high-throughput technology, plasma microbial cell-free DNA (mcfDNA) sequencing can detect unknown pathogens independent of previous clinical or laboratory information. In this study, a total of 199 cases suspected of bloodstream infection (BSI) from January 2020 to June 2020 were collected, and potential pathogens were detected by simultaneous blood culture and plasma mcfDNA sequencing. Other clinical microbiological assays were performed within 7 days of plasma mcfDNA sequencing, including smear, culture of samples taken from relevant infected sites, and β-D-glucan/galactomannan (BDG/GM) tests, among others. The diagnoses were classified as sepsis [94 (47.2%)], non-sepsis [87 (43.7%)], and non-infectious disease [18 (9.0%)]. The sensitivity and specificity of plasma mcfDNA sequencing for diagnosing sepsis were 68.1 and 63.2%, respectively, which were significantly better than those of blood culture, especially for the common bacteria that cause hospital-acquired infection, namely, Acinetobacter baumannii ( p &lt; 0.01) and Klebsiella pneumoniae ( p &lt; 0.01), and DNA viruses (plasma mcfDNA sequencing only, p &lt; 0.01). However, there was no significant difference in the rate of positivity between plasma mcfDNA sequencing and blood culture for antibiotic-non-exposed cases (43.6 vs. 30.9%, p = 0.17). In the non-sepsis group, 44.8% of cases (13/29) detected only by plasma mcfDNA sequencing showed infections in other parts of the body, such as lower respiratory infection (LRI), intra-abdominal infection (IAI) and central nervous system infection (CNSI). For some common pathogens (not including anaerobes), turnaround time (TAT) 3 (TAT from the initiation of blood sample processing by nucleic acid extraction to the completion of sequencing analysis) was longer than TAT1 (TAT from blood culture bottles in Virtuo to off Virtuo). With disease progression, significant dynamic changes in microbial species were clearly detected by plasma mcfDNA sequencing." @default.
• W3166362886 created "2021-06-22" @default.
• W3166362886 creator A5003457826 @default.
• W3166362886 creator A5010249213 @default.
• W3166362886 creator A5019912790 @default.
• W3166362886 creator A5023492006 @default.
• W3166362886 creator A5040981785 @default.
• W3166362886 creator A5054172647 @default.
• W3166362886 creator A5065019668 @default.
• W3166362886 date "2021-05-28" @default.
• W3166362886 modified "2023-10-11" @default.
• W3166362886 title "Plasma Microbial Cell-Free DNA Sequencing Technology for the Diagnosis of Sepsis in the ICU" @default.
• W3166362886 cites W2273527755 @default.
• W3166362886 cites W2463042271 @default.
• W3166362886 cites W2517894594 @default.
• W3166362886 cites W2519453043 @default.
• W3166362886 cites W2761489767 @default.
• W3166362886 cites W2801360758 @default.
• W3166362886 cites W2807517165 @default.
• W3166362886 cites W2896770224 @default.
• W3166362886 cites W2925016229 @default.
• W3166362886 cites W2953017819 @default.
• W3166362886 cites W2958994975 @default.
• W3166362886 cites W2980950402 @default.
• W3166362886 cites W2994455367 @default.
• W3166362886 cites W3000477794 @default.
• W3166362886 cites W3015658621 @default.
• W3166362886 cites W3016555942 @default.
• W3166362886 cites W3021366144 @default.
• W3166362886 cites W3023620462 @default.
• W3166362886 cites W3049554052 @default.
• W3166362886 cites W3099584446 @default.
• W3166362886 cites W3116903175 @default.
• W3166362886 doi "https://doi.org/10.3389/fmolb.2021.659390" @default.
• W3166362886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8194294" @default.
• W3166362886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34124149" @default.
• W3166362886 hasPublicationYear "2021" @default.
• W3166362886 type Work @default.
• W3166362886 sameAs 3166362886 @default.
• W3166362886 citedByCount "11" @default.
• W3166362886 countsByYear W31663628862022 @default.
• W3166362886 countsByYear W31663628862023 @default.
• W3166362886 crossrefType "journal-article" @default.
• W3166362886 hasAuthorship W3166362886A5003457826 @default.
• W3166362886 hasAuthorship W3166362886A5010249213 @default.
• W3166362886 hasAuthorship W3166362886A5019912790 @default.
• W3166362886 hasAuthorship W3166362886A5023492006 @default.
• W3166362886 hasAuthorship W3166362886A5040981785 @default.
• W3166362886 hasAuthorship W3166362886A5054172647 @default.
• W3166362886 hasAuthorship W3166362886A5065019668 @default.
• W3166362886 hasBestOaLocation W31663628861 @default.
• W3166362886 hasConcept C126322002 @default.
• W3166362886 hasConcept C203014093 @default.
• W3166362886 hasConcept C2776315533 @default.
• W3166362886 hasConcept C2776376669 @default.
• W3166362886 hasConcept C2776460866 @default.
• W3166362886 hasConcept C2777637488 @default.
• W3166362886 hasConcept C2778384902 @default.
• W3166362886 hasConcept C2779473907 @default.
• W3166362886 hasConcept C501593827 @default.
• W3166362886 hasConcept C51679486 @default.
• W3166362886 hasConcept C523546767 @default.
• W3166362886 hasConcept C54355233 @default.
• W3166362886 hasConcept C552990157 @default.
• W3166362886 hasConcept C71924100 @default.
• W3166362886 hasConcept C86803240 @default.
• W3166362886 hasConcept C89423630 @default.
• W3166362886 hasConceptScore W3166362886C126322002 @default.
• W3166362886 hasConceptScore W3166362886C203014093 @default.
• W3166362886 hasConceptScore W3166362886C2776315533 @default.
• W3166362886 hasConceptScore W3166362886C2776376669 @default.
• W3166362886 hasConceptScore W3166362886C2776460866 @default.
• W3166362886 hasConceptScore W3166362886C2777637488 @default.
• W3166362886 hasConceptScore W3166362886C2778384902 @default.
• W3166362886 hasConceptScore W3166362886C2779473907 @default.
• W3166362886 hasConceptScore W3166362886C501593827 @default.
• W3166362886 hasConceptScore W3166362886C51679486 @default.
• W3166362886 hasConceptScore W3166362886C523546767 @default.
• W3166362886 hasConceptScore W3166362886C54355233 @default.
• W3166362886 hasConceptScore W3166362886C552990157 @default.
• W3166362886 hasConceptScore W3166362886C71924100 @default.
• W3166362886 hasConceptScore W3166362886C86803240 @default.
• W3166362886 hasConceptScore W3166362886C89423630 @default.
• W3166362886 hasLocation W31663628861 @default.
• W3166362886 hasLocation W31663628862 @default.
• W3166362886 hasOpenAccess W3166362886 @default.
• W3166362886 hasPrimaryLocation W31663628861 @default.
• W3166362886 hasRelatedWork W10007496 @default.
• W3166362886 hasRelatedWork W1968602861 @default.
• W3166362886 hasRelatedWork W2028386564 @default.
• W3166362886 hasRelatedWork W2418976210 @default.
• W3166362886 hasRelatedWork W2613215671 @default.
• W3166362886 hasRelatedWork W2766491151 @default.
• W3166362886 hasRelatedWork W3166362886 @default.
• W3166362886 hasRelatedWork W3178472217 @default.
• W3166362886 hasRelatedWork W3429368 @default.
• W3166362886 hasRelatedWork W4283313781 @default.
• W3166362886 hasVolume "8" @default.
• W3166362886 isParatext "false" @default.
• W3166362886 isRetracted "false" @default.

• next