FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166393072> ?p ?o ?g. }

• W3166393072 endingPage "3992" @default.
• W3166393072 startingPage "3974" @default.
• W3166393072 abstract "Here, we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparum in humans. This study was conducted in an area of high seasonal malaria transmission in Bongo District, Ghana. IRS was implemented during the dry season (November-May) in three consecutive years between 2013 and 2015 to reduce transmission and attempt to bottleneck the parasite population in humans towards lower diversity with greater linkage disequilibrium. The study was done against a background of widespread use of long-lasting insecticidal nets, typical for contemporary malaria control in West Africa. Microsatellite genotyping with 10 loci was used to construct 392 P. falciparum multilocus infection haplotypes collected from two age-stratified cross-sectional surveys at the end of the wet seasons pre- and post-IRS. Three-rounds of IRS, under operational conditions, led to a >90% reduction in transmission intensity and a 35.7% reduction in the P. falciparum prevalence (p < .001). Despite these declines, population genetic analysis of the infection haplotypes revealed no dramatic changes with only a slight, but significant increase in genetic diversity (He : pre-IRS = 0.79 vs. post-IRS = 0.81, p = .048). Reduced relatedness of the parasite population (p < .001) was observed post-IRS, probably due to decreased opportunities for outcrossing. Spatiotemporal genetic differentiation between the pre- and post-IRS surveys (D = 0.0329 [95% CI: 0.0209 - 0.0473], p = .034) was identified. These data provide a genetic explanation for the resilience of P. falciparum to short-term IRS programmes in high-transmission settings in sub-Saharan Africa." @default.
• W3166393072 created "2021-06-22" @default.
• W3166393072 creator A5002494920 @default.
• W3166393072 creator A5004050368 @default.
• W3166393072 creator A5004594547 @default.
• W3166393072 creator A5009051661 @default.
• W3166393072 creator A5016184211 @default.
• W3166393072 creator A5029353419 @default.
• W3166393072 creator A5038441670 @default.
• W3166393072 creator A5047487804 @default.
• W3166393072 creator A5048534219 @default.
• W3166393072 creator A5057762285 @default.
• W3166393072 creator A5090957946 @default.
• W3166393072 date "2021-07-16" @default.
• W3166393072 modified "2023-10-16" @default.
• W3166393072 title "The impact of indoor residual spraying on <i>Plasmodium falciparum</i> microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa" @default.
• W3166393072 cites W1497104559 @default.
• W3166393072 cites W1593524879 @default.
• W3166393072 cites W1729017034 @default.
• W3166393072 cites W1913281388 @default.
• W3166393072 cites W1984690219 @default.
• W3166393072 cites W1998019829 @default.
• W3166393072 cites W2001835403 @default.
• W3166393072 cites W2016603972 @default.
• W3166393072 cites W2033407752 @default.
• W3166393072 cites W2035839217 @default.
• W3166393072 cites W2039227742 @default.
• W3166393072 cites W2050811145 @default.
• W3166393072 cites W2052410578 @default.
• W3166393072 cites W2055463904 @default.
• W3166393072 cites W2056531240 @default.
• W3166393072 cites W2059189547 @default.
• W3166393072 cites W2062584673 @default.
• W3166393072 cites W2077053002 @default.
• W3166393072 cites W2083813474 @default.
• W3166393072 cites W2092963097 @default.
• W3166393072 cites W2094649888 @default.
• W3166393072 cites W2098126593 @default.
• W3166393072 cites W2103571367 @default.
• W3166393072 cites W2114680446 @default.
• W3166393072 cites W2116729094 @default.
• W3166393072 cites W2120143001 @default.
• W3166393072 cites W2121301868 @default.
• W3166393072 cites W2122002897 @default.
• W3166393072 cites W2123284622 @default.
• W3166393072 cites W2127005727 @default.
• W3166393072 cites W2142644281 @default.
• W3166393072 cites W2144573758 @default.
• W3166393072 cites W2146290595 @default.
• W3166393072 cites W2147299002 @default.
• W3166393072 cites W2153014491 @default.
• W3166393072 cites W2159748604 @default.
• W3166393072 cites W2160517750 @default.
• W3166393072 cites W2161339576 @default.
• W3166393072 cites W2165672288 @default.
• W3166393072 cites W2167394796 @default.
• W3166393072 cites W2167464793 @default.
• W3166393072 cites W2170093840 @default.
• W3166393072 cites W2170874271 @default.
• W3166393072 cites W2171787842 @default.
• W3166393072 cites W2205470162 @default.
• W3166393072 cites W2259556556 @default.
• W3166393072 cites W2331001974 @default.
• W3166393072 cites W2536811010 @default.
• W3166393072 cites W2588184413 @default.
• W3166393072 cites W2610356758 @default.
• W3166393072 cites W2727240830 @default.
• W3166393072 cites W2740563942 @default.
• W3166393072 cites W2781714584 @default.
• W3166393072 cites W2782845311 @default.
• W3166393072 cites W2788650779 @default.
• W3166393072 cites W2884817568 @default.
• W3166393072 cites W2908798784 @default.
• W3166393072 cites W2951460048 @default.
• W3166393072 cites W2964792508 @default.
• W3166393072 cites W3088286028 @default.
• W3166393072 cites W3166393072 @default.
• W3166393072 cites W4237230653 @default.
• W3166393072 cites W4243658490 @default.
• W3166393072 cites W4297845758 @default.
• W3166393072 cites W4385786843 @default.
• W3166393072 doi "https://doi.org/10.1111/mec.16029" @default.
• W3166393072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8456823" @default.
• W3166393072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34143538" @default.
• W3166393072 hasPublicationYear "2021" @default.
• W3166393072 type Work @default.
• W3166393072 sameAs 3166393072 @default.
• W3166393072 citedByCount "5" @default.
• W3166393072 countsByYear W31663930722021 @default.
• W3166393072 countsByYear W31663930722022 @default.
• W3166393072 countsByYear W31663930722023 @default.
• W3166393072 crossrefType "journal-article" @default.
• W3166393072 hasAuthorship W3166393072A5002494920 @default.
• W3166393072 hasAuthorship W3166393072A5004050368 @default.
• W3166393072 hasAuthorship W3166393072A5004594547 @default.
• W3166393072 hasAuthorship W3166393072A5009051661 @default.
• W3166393072 hasAuthorship W3166393072A5016184211 @default.
• W3166393072 hasAuthorship W3166393072A5029353419 @default.

• next