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- W3166505953 abstract "Purpose: To assess colour vision in Age-related macular degeneration (AMD) while relating chromatic sensitivity to the severity of AMD and AMD morphologies such as drusen and reticular pseudodrusen. To evaluate if chromatic functional loss precedes structural changes in initial stages of AMD, and if it can be a valuable risk stratification tool for advanced AMD. Methods: Chromatic sensitivity was tested using the Colour Assessment and Diagnosis (CAD) test developed by City, University of London and correlated to the structural changes from fundus photography and spectral domain OCT. All patients were asymptomatic with a visual acuity of 6/12 or better. CAD thresholds were compared to clinical classification in all AMD eyes (Ferris et al., 2013); Soft drusen and Reticular drusen (RPD); Central macular thickness (CMT); Fundus autofluorescence (FAF) pattern (Einbock et al., 2005; Wong et al., 2014) and Soft drusen characteristics (Bird et al., 1995). Cases of conversion to ‘Wet’ AMD were identified through a repeat clinical assessment after the first 12 months. Chromatic sensitivity in early onset drusen (EOD) included comparing their colour thresholds to AMD eyes. Student t-test were used for correlation and P 200 μm was statistically significant with P<0.01 for RG and <0.002 for YB. Review of baseline CAD thresholds in cases converted to wet AMD at the end of 12 months, revealed six eyes had converted to wet AMD. The baseline CAD thresholds of these eyes were not conclusive of being predictive of the impending change to wet AMD. Conclusions: The visual acuity and hence the integrity of cone photoreceptors remains relatively unaffected in early and intermediate stages of AMD. The processing of cone signals in the retina can however be heavily disrupted with subsequent loss of both YB and RG chromatic sensitivity in the eyes. The greatest losses relate to eyes with reticular pseudodrusen. Chromatic sensitivity change was indicative in early macular thinning but failed to herald the onset of wet AMD in our study sample." @default.
- W3166505953 created "2021-06-22" @default.
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- W3166505953 date "2018-01-01" @default.
- W3166505953 modified "2023-09-27" @default.
- W3166505953 title "Loss of chromatic sensitivity in patients with age-related maculopathy - correlation with structural changes in the retina" @default.
- W3166505953 hasPublicationYear "2018" @default.
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