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• W3166509563 endingPage "113606" @default.
• W3166509563 startingPage "113606" @default.
• W3166509563 abstract "Leishmaniasis is a parasitic neglected tropical disease caused by various species of Leishmania parasite. Despite tremendous advancements in the therapeutic sector and drug development strategies, still the existing anti-leishmanial agents are associated with some clinical issues like drug resistance, toxicity and selectivity. Therefore, several research groups are continuously working towards the development of new therapeutic candidates to overcome these issues. Many potential heterocyclic moieties have been explored for this purpose including triazoles, chalcones, chromone, thiazoles, thiosemicarbazones, indole, quinolines, etc. It is evident from the literature that the majority of anti-leishmanial agents act by interacting with key regulators including PTR-I, DHFR, Ld MetAP1, MAPK, 14 α-demethylase and pteridine reductase-I, etc. Also, these tend to induce the production of ROS which causes damage to parasites. In the present compilation, authors have summarized various significant synthetic procedures for anti-leishmanial agents reported in recent years. A brief description of the pharmacological potentials of synthesized compounds along with important aspects related to structural activity relationship has been provided. Important docking outcomes highlighting the possible mode of interaction for the reported compounds have also been included. This review would be helpful to the scientific community to design newer strategies and also to develop novel therapeutic candidates against leishmaniasis. • Leishmaniasis is a tropical neglected disease with worldwide prevalence. • There are drug resistance, toxicity and selectivity issues with the existing drugs. • Heterocyclics exhibit anti-leishmanial action by interacting with various targets. • This review has focussed on synthetic strategies and SAR studies of various heterocyclic classes as anti-leishmanial agents." @default.
• W3166509563 created "2021-06-22" @default.
• W3166509563 creator A5002296992 @default.
• W3166509563 creator A5057084080 @default.
• W3166509563 creator A5078763625 @default.
• W3166509563 creator A5082736233 @default.
• W3166509563 date "2021-11-01" @default.
• W3166509563 modified "2023-10-04" @default.
• W3166509563 title "Recent advancements in anti-leishmanial research: Synthetic strategies and structural activity relationships" @default.
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