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• W3166572063 startingPage "113838" @default.
• W3166572063 abstract "Restoring effective anti-tumor immune responses to cure cancer is a promising strategy, but challenging to achieve due to the intricate crosstalk between tumor and immune cells. While it is established that tumor cells acquire traits to escape immune recognition, the involvement of extracellular vesicles (EVs) in curbing immune cell activation is rapidly emerging. By assisting cancer cells in spreading immunomodulatory signals in the form of (glyco)proteins, lipids, nucleic acids and metabolic regulators, EVs recently emerged as versatile mediators of immune suppression. Blocking their action might reactivate immune cell function and natural antitumor immune responses. Alternatively, EV communication may be exploited to boost anti-tumor immunity. Indeed, novel insights into EV biology paved the way for efficient ex vivo production of 'rationally engineered' EVs that function as potent antitumor vaccines or carry out specific functional tasks. In this review we discuss the latest findings on immune regulation by cancer EVs and explore how EV-mediated communication can be either targeted or harnessed to restore immunity as a means for cancer therapy." @default.
• W3166572063 created "2021-06-22" @default.
• W3166572063 creator A5006175155 @default.
• W3166572063 creator A5032550764 @default.
• W3166572063 creator A5063415290 @default.
• W3166572063 creator A5073249757 @default.
• W3166572063 date "2021-09-01" @default.
• W3166572063 modified "2023-10-16" @default.
• W3166572063 title "Harnessing EV communication to restore antitumor immunity." @default.
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