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• W3166691512 endingPage "181" @default.
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• W3166691512 abstract "• We synthesize ADHD neuroimaging findings on the reward system with findings in obesity, depression, and substance use disorder. • We analyze findings from monetary incentive delay (MID) and delay discounting (DD) tasks, and striatal connectivity and volumetry. • We discuss these neuroimaging features in ADHD, obesity, depression and substance use disorder and ask whether ADHD heterogeneity and comorbidity are reflected by a common dysregulation in the reward system. • We highlight conceptual issues related to heterogeneous paradigms, different phenotyping, and longitudinal prediction. ADHD is a disorder characterized by changes in the reward system and which is highly comorbid with other mental disorders, suggesting common neurobiological pathways. Transdiagnostic neuroimaging findings could help to understand whether a dysregulated reward pathway might be the actual link between ADHD and its comorbidities. We here synthesize ADHD neuroimaging findings on the reward system with findings in obesity, depression, and substance use disorder including their comorbid appearance regarding neuroanatomical features (structural MRI) and activation patterns (resting-state and functional MRI). We focus on findings from monetary-incentive-delay (MID) and delay-discounting (DD) tasks and then review data on striatal connectivity and volumetry. Next, for better understanding of comorbidity in adult ADHD, we discuss these neuroimaging features in ADHD, obesity, depression and substance use disorder and ask whether ADHD heterogeneity and comorbidity are reflected by a common dysregulation in the reward system. Finally, we highlight conceptual issues related to heterogeneous paradigms, different phenotyping, longitudinal prediction and highlight some promising future directions for using striatal reward functioning as a clinical biomarker." @default.
• W3166691512 created "2021-06-22" @default.
• W3166691512 creator A5008957581 @default.
• W3166691512 creator A5009149756 @default.
• W3166691512 creator A5037306868 @default.
• W3166691512 creator A5038874292 @default.
• W3166691512 creator A5039784552 @default.
• W3166691512 creator A5052673298 @default.
• W3166691512 creator A5056475905 @default.
• W3166691512 creator A5064720379 @default.
• W3166691512 date "2021-09-01" @default.
• W3166691512 modified "2023-10-16" @default.
• W3166691512 title "Transdiagnostic neuroimaging of reward system phenotypes in ADHD and comorbid disorders" @default.
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