FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166708124> ?p ?o ?g. }

• W3166708124 endingPage "73" @default.
• W3166708124 startingPage "64" @default.
• W3166708124 abstract "In this work, to improve the solubility and bioavailability of the rosuvastatin (RSV) drug, chitosan-coated mesoporous silica nanoparticles (CS-MSNs) as a drug delivery system were fabricated.To do this, first MSNs with a maximum specific surface area were synthesized from sodium silicate as silica source and different molar ratios of cethyl trimethylammonium bromide (CTAB) and pluronics (P123, PEO20PPO17PEO20) as surfactants via the sol-gel process. Then, the synthesized MSNs were coated by CS polymer with the help of (3-glycidoxypropyl)methyldiethoxysilane (GPTMS) as a linker between MSNs and CS. Subsequently, the RSV drug was loaded into the synthesized CS-coated MSNs. The products were characterized by different techniques, including X-ray diffraction (XRD), the Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FTIR). The in vitro drug release profile of the fabricated DDS was evaluated in a typical phosphate-buffered saline (PBS) solution at different pH values (i.e., 4, 6, and 7.4) for 48 h. To assess the cytotoxicity, the viability of the human fibroblast cells exposed to the fabricated DDS was also examined.The results showed that at an optimal molar ratio of P123/CTAB, the amorphous MSNs with a specific surface area of about 1080 m2/g, a pore diameter of 4 nm, a pore volume of 1.1 cm3/g, and an average size of about 30 nm were synthesized. Also, the presence of all the components, including the CS coating and the RSV drug, was confirmed in the structure of the fabricated DDS by FTIR analysis. Due to the pH-responsive feature of the CS coating, the RSV drug release from the fabricated DDS showed a reasonable environmental response; as the pH value of the PBS solution decreased, the degree of drug release increased.The CS coating enhanced the cytotoxicity of the fabricated DDS and led to sustainable drug release behavior, which would provide a beneficial approach for drug delivery technology." @default.
• W3166708124 created "2021-06-22" @default.
• W3166708124 creator A5027128717 @default.
• W3166708124 creator A5037305029 @default.
• W3166708124 creator A5051253514 @default.
• W3166708124 date "2022-01-01" @default.
• W3166708124 modified "2023-10-15" @default.
• W3166708124 title "Fabrication of Chitosan-coated Mesoporous Silica Nanoparticles Bearing Rosuvastatin as a Drug Delivery System" @default.
• W3166708124 cites W1971859416 @default.
• W3166708124 cites W1987202454 @default.
• W3166708124 cites W1994640985 @default.
• W3166708124 cites W2006053802 @default.
• W3166708124 cites W2011086083 @default.
• W3166708124 cites W2015757465 @default.
• W3166708124 cites W2016128248 @default.
• W3166708124 cites W2018333796 @default.
• W3166708124 cites W2021479394 @default.
• W3166708124 cites W2034410263 @default.
• W3166708124 cites W2034854042 @default.
• W3166708124 cites W2058293286 @default.
• W3166708124 cites W2069573714 @default.
• W3166708124 cites W2078522289 @default.
• W3166708124 cites W2079439851 @default.
• W3166708124 cites W2085448021 @default.
• W3166708124 cites W2085605828 @default.
• W3166708124 cites W2089701454 @default.
• W3166708124 cites W2090349378 @default.
• W3166708124 cites W2090726202 @default.
• W3166708124 cites W2098343793 @default.
• W3166708124 cites W2102699720 @default.
• W3166708124 cites W2108190197 @default.
• W3166708124 cites W2111423624 @default.
• W3166708124 cites W2118236535 @default.
• W3166708124 cites W2130166533 @default.
• W3166708124 cites W2143463421 @default.
• W3166708124 cites W2161560309 @default.
• W3166708124 cites W2167577902 @default.
• W3166708124 cites W2294185571 @default.
• W3166708124 cites W2416986263 @default.
• W3166708124 cites W2564707058 @default.
• W3166708124 cites W2801902427 @default.
• W3166708124 cites W2805467235 @default.
• W3166708124 cites W2886762477 @default.
• W3166708124 cites W2941493172 @default.
• W3166708124 cites W2944164211 @default.
• W3166708124 cites W2964582591 @default.
• W3166708124 cites W2971028128 @default.
• W3166708124 cites W2982248578 @default.
• W3166708124 cites W2998027796 @default.
• W3166708124 cites W3016013889 @default.
• W3166708124 cites W3035485113 @default.
• W3166708124 cites W3045826004 @default.
• W3166708124 cites W3048582256 @default.
• W3166708124 cites W3055754872 @default.
• W3166708124 cites W3083092498 @default.
• W3166708124 cites W3088002445 @default.
• W3166708124 cites W3121782531 @default.
• W3166708124 cites W3126022562 @default.
• W3166708124 cites W3127637304 @default.
• W3166708124 doi "https://doi.org/10.2174/1567201818666210609165630" @default.
• W3166708124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34151762" @default.
• W3166708124 hasPublicationYear "2022" @default.
• W3166708124 type Work @default.
• W3166708124 sameAs 3166708124 @default.
• W3166708124 citedByCount "2" @default.
• W3166708124 countsByYear W31667081242022 @default.
• W3166708124 countsByYear W31667081242023 @default.
• W3166708124 crossrefType "journal-article" @default.
• W3166708124 hasAuthorship W3166708124A5027128717 @default.
• W3166708124 hasAuthorship W3166708124A5037305029 @default.
• W3166708124 hasAuthorship W3166708124A5051253514 @default.
• W3166708124 hasConcept C127413603 @default.
• W3166708124 hasConcept C13965031 @default.
• W3166708124 hasConcept C14631669 @default.
• W3166708124 hasConcept C155672457 @default.
• W3166708124 hasConcept C160892712 @default.
• W3166708124 hasConcept C161790260 @default.
• W3166708124 hasConcept C171250308 @default.
• W3166708124 hasConcept C178790620 @default.
• W3166708124 hasConcept C185592680 @default.
• W3166708124 hasConcept C192562407 @default.
• W3166708124 hasConcept C2777496208 @default.
• W3166708124 hasConcept C2779732960 @default.
• W3166708124 hasConcept C2779820397 @default.
• W3166708124 hasConcept C42360764 @default.
• W3166708124 hasConcept C82776694 @default.
• W3166708124 hasConceptScore W3166708124C127413603 @default.
• W3166708124 hasConceptScore W3166708124C13965031 @default.
• W3166708124 hasConceptScore W3166708124C14631669 @default.
• W3166708124 hasConceptScore W3166708124C155672457 @default.
• W3166708124 hasConceptScore W3166708124C160892712 @default.
• W3166708124 hasConceptScore W3166708124C161790260 @default.
• W3166708124 hasConceptScore W3166708124C171250308 @default.
• W3166708124 hasConceptScore W3166708124C178790620 @default.
• W3166708124 hasConceptScore W3166708124C185592680 @default.
• W3166708124 hasConceptScore W3166708124C192562407 @default.
• W3166708124 hasConceptScore W3166708124C2777496208 @default.
• W3166708124 hasConceptScore W3166708124C2779732960 @default.

• next