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- W3166838355 endingPage "826" @default.
- W3166838355 startingPage "807" @default.
- W3166838355 abstract "B cells express 4 phosphatidylinositol 3-kinase (PI3K) isoforms and have a dependence on p110δ for survival. The design of isoform-selective inhibitors is possible, and pharmacologic inhibition of p110δ is toxic to neoplastic chronic lymphocytic leukemia (CLL) cells for both cell-intrinsic and cell-extrinsic reasons. Idelalisib is a first-in-class p110δ inhibitor that exhibits efficacy for the treatment of relapsed CLL irrespective of adverse prognostic features. Duvelisib is a p110γ/δ inhibitor with a similar efficacy and safety profile to idelalisib. Recent data indicate that umbralisib, a p110δ/CK-1ε dual inhibitor, is safe and effective when administered to patients with CLL." @default.
- W3166838355 created "2021-06-22" @default.
- W3166838355 creator A5016570475 @default.
- W3166838355 creator A5017380326 @default.
- W3166838355 date "2021-08-01" @default.
- W3166838355 modified "2023-10-18" @default.
- W3166838355 title "The Evolving Use of Phosphatidylinositol 3-Kinase Inhibitors for the Treatment of Chronic Lymphocytic Leukemia" @default.
- W3166838355 cites W1511458616 @default.
- W3166838355 cites W1525326448 @default.
- W3166838355 cites W1535438232 @default.
- W3166838355 cites W1566581202 @default.
- W3166838355 cites W1600503988 @default.
- W3166838355 cites W1609120034 @default.
- W3166838355 cites W1945662522 @default.
- W3166838355 cites W1967215435 @default.
- W3166838355 cites W1980040544 @default.
- W3166838355 cites W2025786205 @default.
- W3166838355 cites W2026602389 @default.
- W3166838355 cites W2027971058 @default.
- W3166838355 cites W2032553162 @default.
- W3166838355 cites W2038053631 @default.
- W3166838355 cites W2057370954 @default.
- W3166838355 cites W2061440101 @default.
- W3166838355 cites W2066564017 @default.
- W3166838355 cites W2067064694 @default.
- W3166838355 cites W2070073293 @default.
- W3166838355 cites W2070487917 @default.
- W3166838355 cites W2077379867 @default.
- W3166838355 cites W2078948501 @default.
- W3166838355 cites W2080551472 @default.
- W3166838355 cites W2095447519 @default.
- W3166838355 cites W2116879609 @default.
- W3166838355 cites W2117438992 @default.
- W3166838355 cites W2120319857 @default.
- W3166838355 cites W2121510983 @default.
- W3166838355 cites W2122546986 @default.
- W3166838355 cites W2124593509 @default.
- W3166838355 cites W2125521670 @default.
- W3166838355 cites W2134861285 @default.
- W3166838355 cites W2140606816 @default.
- W3166838355 cites W2154992334 @default.
- W3166838355 cites W2163577434 @default.
- W3166838355 cites W2164932894 @default.
- W3166838355 cites W2169450835 @default.
- W3166838355 cites W2198189188 @default.
- W3166838355 cites W2337485820 @default.
- W3166838355 cites W2396328865 @default.
- W3166838355 cites W2408949002 @default.
- W3166838355 cites W2469555883 @default.
- W3166838355 cites W2520601585 @default.
- W3166838355 cites W2545309317 @default.
- W3166838355 cites W2581658669 @default.
- W3166838355 cites W2587810027 @default.
- W3166838355 cites W2594646846 @default.
- W3166838355 cites W2729141564 @default.
- W3166838355 cites W2775670706 @default.
- W3166838355 cites W2788838674 @default.
- W3166838355 cites W2885065879 @default.
- W3166838355 cites W2890522950 @default.
- W3166838355 cites W2895287765 @default.
- W3166838355 cites W2902472954 @default.
- W3166838355 cites W2902706178 @default.
- W3166838355 cites W2903942209 @default.
- W3166838355 cites W2907555512 @default.
- W3166838355 cites W2909281849 @default.
- W3166838355 cites W2911688003 @default.
- W3166838355 cites W2913393274 @default.
- W3166838355 cites W2913987637 @default.
- W3166838355 cites W2914691947 @default.
- W3166838355 cites W2917721259 @default.
- W3166838355 cites W2936399310 @default.
- W3166838355 cites W2938268271 @default.
- W3166838355 cites W2948436219 @default.
- W3166838355 cites W2952924845 @default.
- W3166838355 cites W2975095928 @default.
- W3166838355 cites W2980882408 @default.
- W3166838355 cites W2983019167 @default.
- W3166838355 cites W2983893848 @default.
- W3166838355 cites W2987791131 @default.
- W3166838355 cites W2997593504 @default.
- W3166838355 cites W2999142839 @default.
- W3166838355 cites W3001171775 @default.
- W3166838355 cites W3005820875 @default.
- W3166838355 cites W3016538158 @default.
- W3166838355 cites W3029637120 @default.
- W3166838355 cites W3030145128 @default.
- W3166838355 cites W3038551276 @default.
- W3166838355 cites W3041074236 @default.
- W3166838355 cites W3045571650 @default.
- W3166838355 cites W3058803995 @default.
- W3166838355 cites W3082899459 @default.
- W3166838355 cites W3095913856 @default.
- W3166838355 cites W3096617651 @default.
- W3166838355 cites W3097286939 @default.
- W3166838355 cites W3115218997 @default.
- W3166838355 cites W3133971371 @default.
- W3166838355 cites W4231547430 @default.
- W3166838355 cites W2049435118 @default.