FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166897333> ?p ?o ?g. }

• W3166897333 endingPage "558" @default.
• W3166897333 startingPage "558" @default.
• W3166897333 abstract "High mobility group box (HMGB)1 action contributes to late phases of sepsis, but the effects of increased endogenous plasma HMGB1 levels on brain cells during inflammation are unclear. Here, we aimed to further investigate the role of HMGB1 in the brain during septic-like lipopolysaccharide-induced inflammation in rats (LPS, 10 mg/kg, i.p.). HMGB-1 mRNA expression and release were measured in the periphery/brain by RT-PCR, immunohistochemistry and ELISA. In vitro experiments with disulfide-HMGB1 in primary neuro-glial cell cultures of the area postrema (AP), a circumventricular organ with a leaky blood–brain barrier and direct access to circulating mediators like HMGB1 and LPS, were performed to determine the direct influence of HMGB1 on this pivotal brain structure for immune-to-brain communication. Indeed, HMGB1 plasma levels stayed elevated after LPS injection. Immunohistochemistry of brains and AP cultures confirmed LPS-stimulated cytoplasmatic translocation of HMGB1 indicative of local HMGB1 release. Moreover, disulfide-HMGB1 stimulation induced nuclear factor (NF)-κB activation and a significant release of interleukin-6, but not tumor necrosis factor α, into AP culture supernatants. However, only a few AP cells directly responded to HMGB1 with increased intracellular calcium concentration. Interestingly, priming with LPS induced a seven-fold higher percentage of responsive cells to HMGB1. We conclude that, as a humoral and local mediator, HMGB1 enhances brain inflammatory responses, after LPS priming, linked to sustained sepsis symptoms." @default.
• W3166897333 created "2021-06-22" @default.
• W3166897333 creator A5001762552 @default.
• W3166897333 creator A5012460578 @default.
• W3166897333 creator A5020295523 @default.
• W3166897333 creator A5026610554 @default.
• W3166897333 creator A5044343178 @default.
• W3166897333 creator A5048356374 @default.
• W3166897333 creator A5056196765 @default.
• W3166897333 creator A5069546468 @default.
• W3166897333 creator A5069748517 @default.
• W3166897333 creator A5076407347 @default.
• W3166897333 creator A5082651939 @default.
• W3166897333 creator A5086779853 @default.
• W3166897333 date "2021-06-11" @default.
• W3166897333 modified "2023-09-27" @default.
• W3166897333 title "LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein" @default.
• W3166897333 cites W115939226 @default.
• W3166897333 cites W1274759939 @default.
• W3166897333 cites W1490007860 @default.
• W3166897333 cites W1503577663 @default.
• W3166897333 cites W1553707188 @default.
• W3166897333 cites W1627944730 @default.
• W3166897333 cites W1818081481 @default.
• W3166897333 cites W1847797033 @default.
• W3166897333 cites W1965764984 @default.
• W3166897333 cites W1969422685 @default.
• W3166897333 cites W1970606114 @default.
• W3166897333 cites W1972492106 @default.
• W3166897333 cites W1978256486 @default.
• W3166897333 cites W1980308944 @default.
• W3166897333 cites W1981037268 @default.
• W3166897333 cites W1984188107 @default.
• W3166897333 cites W1997531886 @default.
• W3166897333 cites W1999974520 @default.
• W3166897333 cites W2000849147 @default.
• W3166897333 cites W2003343375 @default.
• W3166897333 cites W2007948281 @default.
• W3166897333 cites W2014566626 @default.
• W3166897333 cites W2017916290 @default.
• W3166897333 cites W2018653121 @default.
• W3166897333 cites W2019916852 @default.
• W3166897333 cites W2019933158 @default.
• W3166897333 cites W2024811515 @default.
• W3166897333 cites W2029263000 @default.
• W3166897333 cites W2040862506 @default.
• W3166897333 cites W2042939195 @default.
• W3166897333 cites W2049450007 @default.
• W3166897333 cites W2050310411 @default.
• W3166897333 cites W2055481159 @default.
• W3166897333 cites W2055683372 @default.
• W3166897333 cites W2058565815 @default.
• W3166897333 cites W2062993799 @default.
• W3166897333 cites W2064510030 @default.
• W3166897333 cites W2067022007 @default.
• W3166897333 cites W2068474470 @default.
• W3166897333 cites W2073489092 @default.
• W3166897333 cites W2075035271 @default.
• W3166897333 cites W2075663643 @default.
• W3166897333 cites W2076143571 @default.
• W3166897333 cites W2077477270 @default.
• W3166897333 cites W2079112084 @default.
• W3166897333 cites W2080126967 @default.
• W3166897333 cites W2083294814 @default.
• W3166897333 cites W2083790597 @default.
• W3166897333 cites W2089373045 @default.
• W3166897333 cites W2092954858 @default.
• W3166897333 cites W2095917499 @default.
• W3166897333 cites W2097236514 @default.
• W3166897333 cites W2103590758 @default.
• W3166897333 cites W2104317921 @default.
• W3166897333 cites W2108522951 @default.
• W3166897333 cites W2114445825 @default.
• W3166897333 cites W2115206790 @default.
• W3166897333 cites W2129589735 @default.
• W3166897333 cites W2130775443 @default.
• W3166897333 cites W2138904303 @default.
• W3166897333 cites W2150279416 @default.
• W3166897333 cites W2150594596 @default.
• W3166897333 cites W2157031657 @default.
• W3166897333 cites W2157651734 @default.
• W3166897333 cites W2160369507 @default.
• W3166897333 cites W2164714222 @default.
• W3166897333 cites W2169465857 @default.
• W3166897333 cites W2177089859 @default.
• W3166897333 cites W2276556721 @default.
• W3166897333 cites W2462799656 @default.
• W3166897333 cites W2490024771 @default.
• W3166897333 cites W2517447208 @default.
• W3166897333 cites W2520908617 @default.
• W3166897333 cites W2529054203 @default.
• W3166897333 cites W2550580634 @default.
• W3166897333 cites W2556505330 @default.
• W3166897333 cites W2726337525 @default.
• W3166897333 cites W2746039086 @default.
• W3166897333 cites W2761428929 @default.
• W3166897333 cites W2769983882 @default.
• W3166897333 cites W2788246607 @default.

• next