Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166964904> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3166964904 abstract "Spinal mechanosensory neurons contacting the cerebrospinal fluid (CSF-cNs) respond to spinal curvature in an asymmetrical manner and contribute to enhancing locomotor speed and stabilizing active posture. In the spinal cord, CSF-cNs feedback inhibition onto primary motoneurons (CaP) and premotor excitatory interneurons (V0-v). Whether CSF-cNs project onto other premotor neurons in spinal cord remained unknown. Anatomical evidence also shows CSF-cNs of rostral spinal cord project axons into hindbrain, yet the hindbrain targets of CSF-cNs in rostral spinal cord are unknown. The goals of my PhD were to resolve the full pattern of projections of CSF-cNs in both spinal cord and hindbrain. In the spinal cord, I observed the CSF-cNs form putative synapses onto the V2a and V3 premotor interneurons. In the hindbrain, I confirmed with electrophysiology that CSF-cNs in the rostral spinal cord form GABAergic synapses onto hindbrain motoneurons controlling the occipital muscles and pectoral fin muscles. Furthermore, I discovered that CSF-cNs formed axo-axonic varicosities with descending axons of reticulospinal neurons that are specifically involved in producing escape behaviors and steering. Finally, ablating rostral CSF-cNs reduced the speed and increased the occurrence of rolling during fast swimming, indicating a role for these neurons in optimization of speed and postural control. Altogether, my work completed the connectivity map of CSF-cNs in both spinal cord and hindbrain and revealed that CSF-cNs provide important sensory feedback during active locomotion via their dense projections onto hindbrain targets." @default.
- W3166964904 created "2021-06-22" @default.
- W3166964904 creator A5042690020 @default.
- W3166964904 date "2020-06-29" @default.
- W3166964904 modified "2023-09-23" @default.
- W3166964904 title "Modulation of hindbrain and spinal locomotor circuits by interoceptive mechanosensory neurons" @default.
- W3166964904 hasPublicationYear "2020" @default.
- W3166964904 type Work @default.
- W3166964904 sameAs 3166964904 @default.
- W3166964904 citedByCount "0" @default.
- W3166964904 crossrefType "dissertation" @default.
- W3166964904 hasAuthorship W3166964904A5042690020 @default.
- W3166964904 hasConcept C105702510 @default.
- W3166964904 hasConcept C126322002 @default.
- W3166964904 hasConcept C135343436 @default.
- W3166964904 hasConcept C169453685 @default.
- W3166964904 hasConcept C169760540 @default.
- W3166964904 hasConcept C17077164 @default.
- W3166964904 hasConcept C2777075493 @default.
- W3166964904 hasConcept C2779177108 @default.
- W3166964904 hasConcept C2780775167 @default.
- W3166964904 hasConcept C529278444 @default.
- W3166964904 hasConcept C71924100 @default.
- W3166964904 hasConcept C86803240 @default.
- W3166964904 hasConceptScore W3166964904C105702510 @default.
- W3166964904 hasConceptScore W3166964904C126322002 @default.
- W3166964904 hasConceptScore W3166964904C135343436 @default.
- W3166964904 hasConceptScore W3166964904C169453685 @default.
- W3166964904 hasConceptScore W3166964904C169760540 @default.
- W3166964904 hasConceptScore W3166964904C17077164 @default.
- W3166964904 hasConceptScore W3166964904C2777075493 @default.
- W3166964904 hasConceptScore W3166964904C2779177108 @default.
- W3166964904 hasConceptScore W3166964904C2780775167 @default.
- W3166964904 hasConceptScore W3166964904C529278444 @default.
- W3166964904 hasConceptScore W3166964904C71924100 @default.
- W3166964904 hasConceptScore W3166964904C86803240 @default.
- W3166964904 hasLocation W31669649041 @default.
- W3166964904 hasOpenAccess W3166964904 @default.
- W3166964904 hasPrimaryLocation W31669649041 @default.
- W3166964904 hasRelatedWork W1477502482 @default.
- W3166964904 hasRelatedWork W1498298419 @default.
- W3166964904 hasRelatedWork W1522031635 @default.
- W3166964904 hasRelatedWork W1606718229 @default.
- W3166964904 hasRelatedWork W1975005112 @default.
- W3166964904 hasRelatedWork W1993875383 @default.
- W3166964904 hasRelatedWork W2005827706 @default.
- W3166964904 hasRelatedWork W2019906341 @default.
- W3166964904 hasRelatedWork W2020004483 @default.
- W3166964904 hasRelatedWork W2024163063 @default.
- W3166964904 hasRelatedWork W2060733811 @default.
- W3166964904 hasRelatedWork W2078474758 @default.
- W3166964904 hasRelatedWork W2199756704 @default.
- W3166964904 hasRelatedWork W2325821887 @default.
- W3166964904 hasRelatedWork W2411814268 @default.
- W3166964904 hasRelatedWork W2432758430 @default.
- W3166964904 hasRelatedWork W3080904564 @default.
- W3166964904 hasRelatedWork W3089980773 @default.
- W3166964904 hasRelatedWork W3137932907 @default.
- W3166964904 hasRelatedWork W3167979637 @default.
- W3166964904 isParatext "false" @default.
- W3166964904 isRetracted "false" @default.
- W3166964904 magId "3166964904" @default.
- W3166964904 workType "dissertation" @default.