Matches in SemOpenAlex for { <https://semopenalex.org/work/W3166994892> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W3166994892 abstract "Formation of the coronary vasculature requires the transformation and differentiation of cells that originate in the proepicardium and form the epicardium. The latter provides the cells that comprise the coronary vessels: endothelial, smooth muscle and pericytes. The first primitive (non-perfused) vasculature consists of endothelial tubes that develop via vasculogenesis. They branch and also fuse with adjacent tubes to form larger channels. The regulation of these events involves many regulating molecules, e.g., GATA, Wilm's Tumor 1, and VEGF and FGF family members. Recent studies document the interdependency of growth factors in this process and indicate that that at least 6 FGFs (1, 2, 4, 8, 9, 18) promote endothelial cell proliferation and tube formation primarily, but not exclusively via FGFR1 signaling. FGF is a key player in the activation of hedgehog which stimulates VEGF signaling. Moreover, stimulation of tubulogenesis requires the availability of both FGF and VEGF. Although VEGF-A and VEGFR-2 are important for vasculogenesis and angiogenesis, VEGF-B and its receptor, VEGFR-1 as well as VEGF–C each contributes to coronary vessel development. Formation of the coronary ostia and main coronary arteries requires VEGF signaling at the precise sites on the aorta where the capillary plexus penetrates the wall of the artery to establish perfusion of the coronary vasculature. Smooth muscle recruitment to the vascular channels is facilitated by FGFs, VEGFs, TGF-β. These signaling events are temporally and spatially regulated and are also influenced by other factors, e.g., neural crest cells, and tissue O2 levels." @default.
- W3166994892 created "2021-06-22" @default.
- W3166994892 creator A5026800037 @default.
- W3166994892 date "2010-04-01" @default.
- W3166994892 modified "2023-09-27" @default.
- W3166994892 title "Signaling and the Progression of Coronary Vessel Formation" @default.
- W3166994892 doi "https://doi.org/10.1096/fasebj.24.1_supplement.62.2" @default.
- W3166994892 hasPublicationYear "2010" @default.
- W3166994892 type Work @default.
- W3166994892 sameAs 3166994892 @default.
- W3166994892 citedByCount "0" @default.
- W3166994892 crossrefType "journal-article" @default.
- W3166994892 hasAuthorship W3166994892A5026800037 @default.
- W3166994892 hasBestOaLocation W31669948921 @default.
- W3166994892 hasConcept C126322002 @default.
- W3166994892 hasConcept C170493617 @default.
- W3166994892 hasConcept C201750760 @default.
- W3166994892 hasConcept C2780394083 @default.
- W3166994892 hasConcept C28328180 @default.
- W3166994892 hasConcept C60781801 @default.
- W3166994892 hasConcept C71924100 @default.
- W3166994892 hasConcept C74373430 @default.
- W3166994892 hasConcept C86803240 @default.
- W3166994892 hasConcept C95444343 @default.
- W3166994892 hasConceptScore W3166994892C126322002 @default.
- W3166994892 hasConceptScore W3166994892C170493617 @default.
- W3166994892 hasConceptScore W3166994892C201750760 @default.
- W3166994892 hasConceptScore W3166994892C2780394083 @default.
- W3166994892 hasConceptScore W3166994892C28328180 @default.
- W3166994892 hasConceptScore W3166994892C60781801 @default.
- W3166994892 hasConceptScore W3166994892C71924100 @default.
- W3166994892 hasConceptScore W3166994892C74373430 @default.
- W3166994892 hasConceptScore W3166994892C86803240 @default.
- W3166994892 hasConceptScore W3166994892C95444343 @default.
- W3166994892 hasIssue "S1" @default.
- W3166994892 hasLocation W31669948921 @default.
- W3166994892 hasOpenAccess W3166994892 @default.
- W3166994892 hasPrimaryLocation W31669948921 @default.
- W3166994892 hasRelatedWork W1973374695 @default.
- W3166994892 hasRelatedWork W1996160446 @default.
- W3166994892 hasRelatedWork W2012753522 @default.
- W3166994892 hasRelatedWork W2034239247 @default.
- W3166994892 hasRelatedWork W2041302684 @default.
- W3166994892 hasRelatedWork W2053290954 @default.
- W3166994892 hasRelatedWork W2122125734 @default.
- W3166994892 hasRelatedWork W2167039827 @default.
- W3166994892 hasRelatedWork W2169406351 @default.
- W3166994892 hasRelatedWork W23803901 @default.
- W3166994892 hasVolume "24" @default.
- W3166994892 isParatext "false" @default.
- W3166994892 isRetracted "false" @default.
- W3166994892 magId "3166994892" @default.
- W3166994892 workType "article" @default.