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• W3167011675 abstract "Emerging evidence suggests that both central and peripheral immunological processes play an important role in the pathogenesis of Alzheimer's disease (AD), but regulatory mechanisms remain unknown. The gut microbiota and its key metabolites are known to affect neuroinflammation by modulating the activity of peripheral and brain-resident immune cells, yet an overview on how the gut microbiota contribute to immunological alterations in AD is lacking. In this review, we discuss current literature on microbiota composition in AD patients and relevant animal models. Next, we highlight how microbiota and their metabolites may contribute to peripheral and central immunological changes in AD. Finally, we offer a future perspective on the translation of these findings into clinical practice by targeting gut microbiota to modulate inflammation in AD. Since we find that gut microbiota alterations in AD can induce peripheral and central immunological changes via the release of microbial metabolites, we propose that modulating their composition may alter ongoing inflammation and could therefore be a promising future strategy to fight progression of AD." @default.
• W3167011675 created "2021-06-22" @default.
• W3167011675 creator A5001774953 @default.
• W3167011675 creator A5003951117 @default.
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• W3167011675 creator A5064354624 @default.
• W3167011675 creator A5073652037 @default.
• W3167011675 creator A5088378152 @default.
• W3167011675 creator A5091824986 @default.
• W3167011675 date "2021-05-31" @default.
• W3167011675 modified "2023-10-10" @default.
• W3167011675 title "Contribution of Gut Microbiota to Immunological Changes in Alzheimer’s Disease" @default.
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