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• W3167080945 abstract "Abstract Nociceptors are primary afferent neurons serving the reception of acute pain but also the transit into maladaptive pain disorders. Since native human nociceptors are hardly available for mechanistic functional research, and rodent models do not necessarily mirror human pathologies in all aspects, human iPSC-derived nociceptors (iDN) offer superior advantages as a human model system. Unbiased mRNA::microRNA co-sequencing, immunofluorescence staining and qPCR validations, revealed expression trajectories as well as miRNA target spaces throughout the transition of pluripotent cells into iDNs. mRNA and miRNA candidates emerged as regulatory hubs for neurite outgrowth, synapse development and ion channel expression. The exploratory data analysis tool NOCICEPTRA is provided as a containerized platform to retrieve experimentally determined expression trajectories, and to query custom gene sets for pathway and disease enrichments. Querying NOCICEPTRA for marker genes of cortical neurogenesis revealed distinct similarities and differences for cortical and peripheral neurons. The platform provides a public domain neuroresource to exploit the entire data sets and explore miRNA and mRNA as hubs regulating human nociceptor differentiation and function." @default.
• W3167080945 created "2021-06-22" @default.
• W3167080945 creator A5025153549 @default.
• W3167080945 creator A5032155895 @default.
• W3167080945 creator A5036753916 @default.
• W3167080945 creator A5040730141 @default.
• W3167080945 creator A5047821411 @default.
• W3167080945 creator A5076677928 @default.
• W3167080945 creator A5091186309 @default.
• W3167080945 date "2021-06-07" @default.
• W3167080945 modified "2023-09-26" @default.
• W3167080945 title "NOCICEPTRA: Gene and microRNA signatures and their trajectories characterizing human iPSC-derived nociceptor maturation" @default.
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