FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3167123103> ?p ?o ?g. }

• W3167123103 endingPage "718" @default.
• W3167123103 startingPage "706" @default.
• W3167123103 abstract "Benzene, a known occupational and environmental contaminant, has been recognized as the hematotoxin and human carcinogen. Lipids have a variety of important physiological functions and the abnormal lipid metabolism has been reported to be closely related to the occurrence and development of many diseases. In the present study, we aim to utilize LC-MS/MS lipidomic platform to identify novel biomarkers and provide scientific clues for mechanism study of benzene hematotoxicity. Results showed that a total of 294 differential metabolites were obtained from the comparison of benzene-treated group and control group. The glycerophospholipid pathway was altered involving the down-regulation of the levels of phosphatidylcholine and phosphatidylserine. In addition, phosphatidylethanolamine (PE) and 1-Acyl-sn-glycero-3-phosphocholine levels were increased in benzene-treated group. Based on the relationship between PE and autophagy, we then found that effective biomarker of autophagy, Beclin1 and LC3B, were increased remarkably. Furthermore, following benzene treatment, significant decreases in glucosylceramide (GlcCer) and phytosphingosine (PHS) levels in sphingolipid pathway were observed. Simultaneously, the levels of proliferation marker (PCNA and Ki67) and apoptosis regulator (Bax and Caspase-3) showed clear increases in benzene-exposed group. Based on our results, we speculate that disturbances in glycerophospholipid pathway play an important role in the process of benzene-induced hematopoietic toxicity by affecting autophagy, while sphingolipid pathway may also serve as a vital role in benzene-caused toxicity by regulating proliferation and apoptosis. Our study provides basic study information for the future biomarker and mechanism research underlying the development of benzene-induced blood toxicity." @default.
• W3167123103 created "2021-06-22" @default.
• W3167123103 creator A5002846482 @default.
• W3167123103 creator A5010165333 @default.
• W3167123103 creator A5010222527 @default.
• W3167123103 creator A5030956231 @default.
• W3167123103 creator A5037341631 @default.
• W3167123103 creator A5039300760 @default.
• W3167123103 creator A5045703368 @default.
• W3167123103 creator A5055614782 @default.
• W3167123103 creator A5058986351 @default.
• W3167123103 creator A5065481111 @default.
• W3167123103 date "2021-06-15" @default.
• W3167123103 modified "2023-10-14" @default.
• W3167123103 title "Lipidomic analysis reveals disturbances in glycerophospholipid and sphingolipid metabolic pathways in benzene-exposed mice" @default.
• W3167123103 cites W1653018988 @default.
• W3167123103 cites W1956167704 @default.
• W3167123103 cites W1986910845 @default.
• W3167123103 cites W2008849171 @default.
• W3167123103 cites W2009527232 @default.
• W3167123103 cites W2023600919 @default.
• W3167123103 cites W2036407540 @default.
• W3167123103 cites W2040157483 @default.
• W3167123103 cites W2044119772 @default.
• W3167123103 cites W2070650327 @default.
• W3167123103 cites W2075924764 @default.
• W3167123103 cites W2112698641 @default.
• W3167123103 cites W2165627875 @default.
• W3167123103 cites W2169859284 @default.
• W3167123103 cites W2260947841 @default.
• W3167123103 cites W2332689000 @default.
• W3167123103 cites W2463375138 @default.
• W3167123103 cites W2541855732 @default.
• W3167123103 cites W2560741245 @default.
• W3167123103 cites W2565766160 @default.
• W3167123103 cites W2588511207 @default.
• W3167123103 cites W2592804355 @default.
• W3167123103 cites W2606631613 @default.
• W3167123103 cites W2736124309 @default.
• W3167123103 cites W2746010707 @default.
• W3167123103 cites W2757029003 @default.
• W3167123103 cites W2788111171 @default.
• W3167123103 cites W2791096912 @default.
• W3167123103 cites W2794865171 @default.
• W3167123103 cites W2888190570 @default.
• W3167123103 cites W2889741216 @default.
• W3167123103 cites W2900111117 @default.
• W3167123103 cites W2901544883 @default.
• W3167123103 cites W2947316660 @default.
• W3167123103 cites W2947765622 @default.
• W3167123103 cites W2948632957 @default.
• W3167123103 cites W2949993838 @default.
• W3167123103 cites W2957721022 @default.
• W3167123103 cites W2979613684 @default.
• W3167123103 cites W2980344383 @default.
• W3167123103 cites W2990911143 @default.
• W3167123103 cites W2997722532 @default.
• W3167123103 cites W3004216030 @default.
• W3167123103 cites W3042474626 @default.
• W3167123103 cites W3045177602 @default.
• W3167123103 cites W3097197688 @default.
• W3167123103 doi "https://doi.org/10.1093/toxres/tfab053" @default.
• W3167123103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8403594" @default.
• W3167123103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34484662" @default.
• W3167123103 hasPublicationYear "2021" @default.
• W3167123103 type Work @default.
• W3167123103 sameAs 3167123103 @default.
• W3167123103 citedByCount "6" @default.
• W3167123103 countsByYear W31671231032022 @default.
• W3167123103 countsByYear W31671231032023 @default.
• W3167123103 crossrefType "journal-article" @default.
• W3167123103 hasAuthorship W3167123103A5002846482 @default.
• W3167123103 hasAuthorship W3167123103A5010165333 @default.
• W3167123103 hasAuthorship W3167123103A5010222527 @default.
• W3167123103 hasAuthorship W3167123103A5030956231 @default.
• W3167123103 hasAuthorship W3167123103A5037341631 @default.
• W3167123103 hasAuthorship W3167123103A5039300760 @default.
• W3167123103 hasAuthorship W3167123103A5045703368 @default.
• W3167123103 hasAuthorship W3167123103A5055614782 @default.
• W3167123103 hasAuthorship W3167123103A5058986351 @default.
• W3167123103 hasAuthorship W3167123103A5065481111 @default.
• W3167123103 hasBestOaLocation W31671231031 @default.
• W3167123103 hasConcept C185592680 @default.
• W3167123103 hasConcept C190283241 @default.
• W3167123103 hasConcept C203522944 @default.
• W3167123103 hasConcept C2776952329 @default.
• W3167123103 hasConcept C2778918659 @default.
• W3167123103 hasConcept C2779637612 @default.
• W3167123103 hasConcept C2781197716 @default.
• W3167123103 hasConcept C41625074 @default.
• W3167123103 hasConcept C55493867 @default.
• W3167123103 hasConcept C61705674 @default.
• W3167123103 hasConcept C86803240 @default.
• W3167123103 hasConcept C95444343 @default.
• W3167123103 hasConceptScore W3167123103C185592680 @default.
• W3167123103 hasConceptScore W3167123103C190283241 @default.
• W3167123103 hasConceptScore W3167123103C203522944 @default.
• W3167123103 hasConceptScore W3167123103C2776952329 @default.

• next