FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3167255552> ?p ?o ?g. }

• W3167255552 endingPage "266" @default.
• W3167255552 startingPage "255" @default.
• W3167255552 abstract "In cellular signaling, the diverse physiological actions of biological gases, including O2, CO, NO, and H2S, have attracted much interest. Hypoxia-inducible factors (HIFs), including HIF-1 and HIF-2, are transcription factors that respond to reduced intracellular O2 availability. Polysulfides are substances containing varying numbers of sulfur atoms (H2Sn) that are generated endogenously from H2S by 3-mercaptopyruvate sulfurtransferase in the presence of O2, and regulate ion channels, specific tumor suppressors, and protein kinases. However, the effect of polysulfides on HIF activation in hypoxic mammalian cells is largely unknown. Here, we have investigated the effect of polysulfide on cells in vitro. In established cell lines, polysulfide donors reversibly reduced cellular O2 consumption and inhibited hypoxia-induced HIF-1α protein accumulation and the expression of genes downstream of HIFs; however, these effects were not observed in anoxia. In Von Hippel-Lindau tumor suppressor (VHL)- and mitochondria-deficient cells, polysulfides did not affect HIF-1α protein synthesis but destabilized it in a VHL- and mitochondria-dependent manner. For the first time, we show that polysulfides modulate intracellular O2 homeostasis and regulate HIF activation and subsequent hypoxia-induced gene expression in a VHL- and mitochondria-dependent manner." @default.
• W3167255552 created "2021-06-22" @default.
• W3167255552 creator A5008948993 @default.
• W3167255552 creator A5025284070 @default.
• W3167255552 creator A5032488382 @default.
• W3167255552 creator A5044784409 @default.
• W3167255552 creator A5050801771 @default.
• W3167255552 creator A5064755348 @default.
• W3167255552 creator A5068420272 @default.
• W3167255552 creator A5069717767 @default.
• W3167255552 creator A5076764999 @default.
• W3167255552 creator A5079934306 @default.
• W3167255552 date "2021-07-01" @default.
• W3167255552 modified "2023-10-17" @default.
• W3167255552 title "Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner" @default.
• W3167255552 cites W1721827275 @default.
• W3167255552 cites W1964037605 @default.
• W3167255552 cites W1967503180 @default.
• W3167255552 cites W1977348409 @default.
• W3167255552 cites W1990509377 @default.
• W3167255552 cites W1991308916 @default.
• W3167255552 cites W1993198132 @default.
• W3167255552 cites W1998664010 @default.
• W3167255552 cites W2018008610 @default.
• W3167255552 cites W2018504915 @default.
• W3167255552 cites W2024206845 @default.
• W3167255552 cites W2027771823 @default.
• W3167255552 cites W2029353661 @default.
• W3167255552 cites W2033323717 @default.
• W3167255552 cites W2036897871 @default.
• W3167255552 cites W2050489252 @default.
• W3167255552 cites W2051215275 @default.
• W3167255552 cites W2060817767 @default.
• W3167255552 cites W2067683280 @default.
• W3167255552 cites W2080630504 @default.
• W3167255552 cites W2085609942 @default.
• W3167255552 cites W2091557653 @default.
• W3167255552 cites W2133258970 @default.
• W3167255552 cites W2165623186 @default.
• W3167255552 cites W2170788298 @default.
• W3167255552 cites W2257037353 @default.
• W3167255552 cites W2319680793 @default.
• W3167255552 cites W2478758015 @default.
• W3167255552 cites W2496791298 @default.
• W3167255552 cites W2525423766 @default.
• W3167255552 cites W2575515814 @default.
• W3167255552 cites W2592811885 @default.
• W3167255552 cites W2604960218 @default.
• W3167255552 cites W2618232647 @default.
• W3167255552 cites W2757554288 @default.
• W3167255552 cites W2903808414 @default.
• W3167255552 cites W2999018780 @default.
• W3167255552 cites W3006173328 @default.
• W3167255552 cites W3009721059 @default.
• W3167255552 cites W3100852364 @default.
• W3167255552 cites W4252417365 @default.
• W3167255552 doi "https://doi.org/10.1016/j.mito.2021.06.007" @default.
• W3167255552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34133955" @default.
• W3167255552 hasPublicationYear "2021" @default.
• W3167255552 type Work @default.
• W3167255552 sameAs 3167255552 @default.
• W3167255552 citedByCount "5" @default.
• W3167255552 countsByYear W31672555522021 @default.
• W3167255552 countsByYear W31672555522022 @default.
• W3167255552 countsByYear W31672555522023 @default.
• W3167255552 crossrefType "journal-article" @default.
• W3167255552 hasAuthorship W3167255552A5008948993 @default.
• W3167255552 hasAuthorship W3167255552A5025284070 @default.
• W3167255552 hasAuthorship W3167255552A5032488382 @default.
• W3167255552 hasAuthorship W3167255552A5044784409 @default.
• W3167255552 hasAuthorship W3167255552A5050801771 @default.
• W3167255552 hasAuthorship W3167255552A5064755348 @default.
• W3167255552 hasAuthorship W3167255552A5068420272 @default.
• W3167255552 hasAuthorship W3167255552A5069717767 @default.
• W3167255552 hasAuthorship W3167255552A5076764999 @default.
• W3167255552 hasAuthorship W3167255552A5079934306 @default.
• W3167255552 hasConcept C104317684 @default.
• W3167255552 hasConcept C147789679 @default.
• W3167255552 hasConcept C17525397 @default.
• W3167255552 hasConcept C178790620 @default.
• W3167255552 hasConcept C185592680 @default.
• W3167255552 hasConcept C2777379467 @default.
• W3167255552 hasConcept C28859421 @default.
• W3167255552 hasConcept C540031477 @default.
• W3167255552 hasConcept C55493867 @default.
• W3167255552 hasConcept C68801617 @default.
• W3167255552 hasConcept C7836513 @default.
• W3167255552 hasConcept C79879829 @default.
• W3167255552 hasConcept C86339819 @default.
• W3167255552 hasConcept C86803240 @default.
• W3167255552 hasConcept C95444343 @default.
• W3167255552 hasConceptScore W3167255552C104317684 @default.
• W3167255552 hasConceptScore W3167255552C147789679 @default.
• W3167255552 hasConceptScore W3167255552C17525397 @default.
• W3167255552 hasConceptScore W3167255552C178790620 @default.
• W3167255552 hasConceptScore W3167255552C185592680 @default.
• W3167255552 hasConceptScore W3167255552C2777379467 @default.
• W3167255552 hasConceptScore W3167255552C28859421 @default.

• next