Matches in SemOpenAlex for { <https://semopenalex.org/work/W3167271608> ?p ?o ?g. }
- W3167271608 endingPage "3035" @default.
- W3167271608 startingPage "3022" @default.
- W3167271608 abstract "Abstract Dysfunction of adipocytes and adipose tissue is a primary defect in obesity and obesity-associated metabolic diseases. Interferon regulatory factor 3 (IRF3) has been implicated in adipogenesis. However, the role of IRF3 in obesity and obesity-associated disorders remains unclear. Here, we show that IRF3 expression in human adipose tissues is positively associated with insulin sensitivity and negatively associated with type 2 diabetes. In mouse pre-adipocytes, deficiency of IRF3 results in increased expression of PPARγ and PPARγ-mediated adipogenic genes, leading to increased adipogenesis and altered adipocyte functionality. The IRF3 knockout (KO) mice develop obesity, insulin resistance, glucose intolerance, and eventually type 2 diabetes with aging, which is associated with the development of white adipose tissue (WAT) inflammation. Increased macrophage accumulation with M1 phenotype which is due to the loss of IFNβ-mediated IL-10 expression is observed in WAT of the KO mice compared to that in wild-type mice. Bone-marrow reconstitution experiments demonstrate that the nonhematopoietic cells are the primary contributors to the development of obesity and both hematopoietic and nonhematopoietic cells contribute to the development of obesity-related complications in IRF3 KO mice. This study demonstrates that IRF3 regulates the biology of multiple cell types including adipocytes and macrophages to prevent the development of obesity and obesity-related complications and hence, could be a potential target for therapeutic interventions for the prevention and treatment of obesity-associated metabolic disorders." @default.
- W3167271608 created "2021-06-22" @default.
- W3167271608 creator A5008204710 @default.
- W3167271608 creator A5008473414 @default.
- W3167271608 creator A5011069259 @default.
- W3167271608 creator A5013918402 @default.
- W3167271608 creator A5014810730 @default.
- W3167271608 creator A5015689468 @default.
- W3167271608 creator A5033116502 @default.
- W3167271608 creator A5036580258 @default.
- W3167271608 creator A5038204612 @default.
- W3167271608 creator A5044336943 @default.
- W3167271608 creator A5045915390 @default.
- W3167271608 creator A5047517310 @default.
- W3167271608 creator A5049845476 @default.
- W3167271608 creator A5058627240 @default.
- W3167271608 creator A5060002817 @default.
- W3167271608 creator A5079777621 @default.
- W3167271608 creator A5090258796 @default.
- W3167271608 date "2021-06-05" @default.
- W3167271608 modified "2023-10-18" @default.
- W3167271608 title "Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3" @default.
- W3167271608 cites W1917777024 @default.
- W3167271608 cites W1964873147 @default.
- W3167271608 cites W1969107610 @default.
- W3167271608 cites W1971279197 @default.
- W3167271608 cites W1976564408 @default.
- W3167271608 cites W1982709555 @default.
- W3167271608 cites W1994212260 @default.
- W3167271608 cites W2000054651 @default.
- W3167271608 cites W2008864204 @default.
- W3167271608 cites W2008869160 @default.
- W3167271608 cites W2010957046 @default.
- W3167271608 cites W2012460974 @default.
- W3167271608 cites W2019011732 @default.
- W3167271608 cites W2036528685 @default.
- W3167271608 cites W2040153748 @default.
- W3167271608 cites W2041544510 @default.
- W3167271608 cites W2045159219 @default.
- W3167271608 cites W2050052221 @default.
- W3167271608 cites W2052045899 @default.
- W3167271608 cites W2052609811 @default.
- W3167271608 cites W2060978273 @default.
- W3167271608 cites W2072087746 @default.
- W3167271608 cites W2076633494 @default.
- W3167271608 cites W2079691056 @default.
- W3167271608 cites W2086581449 @default.
- W3167271608 cites W2086667228 @default.
- W3167271608 cites W2089077517 @default.
- W3167271608 cites W2089766365 @default.
- W3167271608 cites W2108399976 @default.
- W3167271608 cites W2118194631 @default.
- W3167271608 cites W2121039744 @default.
- W3167271608 cites W2123371309 @default.
- W3167271608 cites W2130657795 @default.
- W3167271608 cites W2131094572 @default.
- W3167271608 cites W2135507245 @default.
- W3167271608 cites W2145697808 @default.
- W3167271608 cites W2147640266 @default.
- W3167271608 cites W2154324324 @default.
- W3167271608 cites W2157559566 @default.
- W3167271608 cites W2163270865 @default.
- W3167271608 cites W2164015929 @default.
- W3167271608 cites W2165334726 @default.
- W3167271608 cites W2166040410 @default.
- W3167271608 cites W2167485774 @default.
- W3167271608 cites W2170651583 @default.
- W3167271608 cites W2173681478 @default.
- W3167271608 cites W2299004983 @default.
- W3167271608 cites W2512695823 @default.
- W3167271608 cites W2888424085 @default.
- W3167271608 cites W2945335272 @default.
- W3167271608 cites W4249727000 @default.
- W3167271608 doi "https://doi.org/10.1038/s41418-021-00798-9" @default.
- W3167271608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8563729" @default.
- W3167271608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34091599" @default.
- W3167271608 hasPublicationYear "2021" @default.
- W3167271608 type Work @default.
- W3167271608 sameAs 3167271608 @default.
- W3167271608 citedByCount "11" @default.
- W3167271608 countsByYear W31672716082022 @default.
- W3167271608 countsByYear W31672716082023 @default.
- W3167271608 crossrefType "journal-article" @default.
- W3167271608 hasAuthorship W3167271608A5008204710 @default.
- W3167271608 hasAuthorship W3167271608A5008473414 @default.
- W3167271608 hasAuthorship W3167271608A5011069259 @default.
- W3167271608 hasAuthorship W3167271608A5013918402 @default.
- W3167271608 hasAuthorship W3167271608A5014810730 @default.
- W3167271608 hasAuthorship W3167271608A5015689468 @default.
- W3167271608 hasAuthorship W3167271608A5033116502 @default.
- W3167271608 hasAuthorship W3167271608A5036580258 @default.
- W3167271608 hasAuthorship W3167271608A5038204612 @default.
- W3167271608 hasAuthorship W3167271608A5044336943 @default.
- W3167271608 hasAuthorship W3167271608A5045915390 @default.
- W3167271608 hasAuthorship W3167271608A5047517310 @default.
- W3167271608 hasAuthorship W3167271608A5049845476 @default.
- W3167271608 hasAuthorship W3167271608A5058627240 @default.
- W3167271608 hasAuthorship W3167271608A5060002817 @default.