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- W3167367204 abstract "Abstract Background Long non-coding RNAs (lncRNAs) structurally resemble mRNAs and exert crucial effects on host immune defense against pathogen infection. Japanese flounder ( Paralichthys olivaceus ) is an economically important marine fish susceptible to Vibrio anguillarum infection. To date, study on lncRNAs in flounder is scarce. Results Here, we reported the first systematic identification and characterization of flounder lncRNAs induced by V . anguillarum infection at different time points. A total of 2,368 lncRNAs were identified, 414 of which were differentially expressed lncRNAs (DElncRNAs) that responded significantly to V . anguillarum infection. For these DElncRNAs, 3,990 target genes (named DETGs) and 42 target miRNAs (named DETmiRs) were identified based on integrated analyses of lncRNA-mRNA and lncRNA-miRNA expressions, respectively. The DETGs were enriched in a cohort of functional pathways associated with immunity. In addition to modulating mRNAs, 36 DElncRNAs were also found to act as competitive endogenous RNAs (ceRNAs) that regulate 37 DETGs through 16 DETmiRs. The DETmiRs, DElncRNAs, and DETGs formed ceRNA regulatory networks consisting of 114 interacting DElncRNAs-DETmiRs-DETGs trinities spanning 10 immune pathways. Conclusions This study provides a comprehensive picture of lncRNAs involved in V . anguillarum infection. The identified lncRNAs and ceRNA networks add new insights into the anti-bacterial immunity of flounder." @default.
- W3167367204 created "2021-06-22" @default.
- W3167367204 creator A5049415248 @default.
- W3167367204 creator A5055889919 @default.
- W3167367204 date "2021-06-15" @default.
- W3167367204 modified "2023-10-10" @default.
- W3167367204 title "Identification and characterization of immune-related lncRNAs and lncRNA-miRNA-mRNA networks of Paralichthys olivaceus involved in Vibrio anguillarum infection" @default.
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- W3167367204 doi "https://doi.org/10.1186/s12864-021-07780-2" @default.
- W3167367204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8204505" @default.
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- W3167367204 hasPublicationYear "2021" @default.
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