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• W3167422201 endingPage "653" @default.
• W3167422201 startingPage "653" @default.
• W3167422201 abstract "This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4+, CD8+ and FOXP3+ TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4+ and CD8+ TILs are significantly associated with smoking and alcohol habits. CD4+ and CD8+ TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3+ TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4+ and CD8+ TILs and a high tumoral CD8+/FOXP3+ ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3+ TILs and a low stromal CD8+/FOXP3+ ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8+/FOXP3+ TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8+/FOXP3+ TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC." @default.
• W3167422201 created "2021-06-22" @default.
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• W3167422201 date "2021-06-08" @default.
• W3167422201 modified "2023-10-18" @default.
• W3167422201 title "Prognostic Relevance of CD4+, CD8+ and FOXP3+ TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers" @default.
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• W3167422201 doi "https://doi.org/10.3390/biomedicines9060653" @default.
• W3167422201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8227658" @default.
• W3167422201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34201050" @default.
• W3167422201 hasPublicationYear "2021" @default.
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