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• W3167493109 endingPage "102648" @default.
• W3167493109 startingPage "102648" @default.
• W3167493109 abstract "Theranostic nanoparticles were developed using synthesized Gadolinium doped iron oxide nanoplatforms by polyol process. Lenalidomide was coated on the magnetic core using PLGA by nanoprecipitation technique. Modification of Polyethylenimine was done with targeting moieties to provide targeting against gliomas. The cell line studies were performed on U87MG glioblastoma cell lines. Toxicity evaluation was done by mucosal toxicity study and hemolysis test. The magnetic core had ultra-small particle size of <10 nm and were paramagnetic with in vitro hyperthermia ability. The theranostic nanoparticles had high entrapment efficiency of 97.82 ± 0.425% and low particle size of 122.26 ± 2.17 nm. Cell line studies revealed the anti-cancer activity of formulation with localization in mitochondria. Toxicity studies on nasal mucosa and hemolysis test proved that the formulation was non-toxic as compared to positive control. Biodistribution studies on Wistar rats revealed the potential of the theranostic nanoparticles in brain targeting by intranasal route. • The theranostic nanoparticles were developed using lanthanide doped iron oxide as template. • The gadolinium doped iron oxide nanoparticles were synthesized by polyol process. • The metallic core was coated with lenalidomide using PLGA along with modified PEI for targeting glioblastoma cell lines. • The developed theranostic nanoparticles showed mitochondrial localization and cytotoxicity in glioblastoma cell lines. • Biodistribution study showed the potential of intranasal delivery of theranostic nanoparticles." @default.
• W3167493109 created "2021-06-22" @default.
• W3167493109 creator A5015515160 @default.
• W3167493109 creator A5033664956 @default.
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• W3167493109 creator A5054273184 @default.
• W3167493109 creator A5064155814 @default.
• W3167493109 creator A5079856735 @default.
• W3167493109 creator A5087696004 @default.
• W3167493109 date "2021-08-01" @default.
• W3167493109 modified "2023-10-14" @default.
• W3167493109 title "Development of mitochondrial targeted theranostic nanocarriers for treatment of gliomas" @default.
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