FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3167555276> ?p ?o ?g. }

• W3167555276 abstract "Optogenetics has a lot of potential to become an effective neuromodulative therapy for clinical applications. Selecting the correct opsin is crucial to have an optimal optogenetic tool. With computational modeling, the neuronal response to the current dynamics of an opsin can be extensively and systematically tested. Unlike electrical stimulation where the effect is directly defined by the applied field, the stimulation in optogenetics is indirect, depending on the selected opsin's non-linear kinetics. With the continuous expansion of opsin possibilities, computational studies are difficult due to the need for an accurate model of the selected opsin first. To this end, we propose a double two-state opsin model as alternative to the conventional three and four state Markov models used for opsin modeling. Furthermore, we provide a fitting procedure, which allows for autonomous model fitting starting from a vast parameter space. With this procedure, we successfully fitted two distinctive opsins (ChR2(H134R) and MerMAID). Both models are able to represent the experimental data with great accuracy and were obtained within an acceptable time frame. This is due to the absence of differential equations in the fitting procedure, with an enormous reduction in computational cost as result. The performance of the proposed model with a fit to ChR2(H134R) was tested, by comparing the neural response in a regular spiking neuron to the response obtained with the non-instantaneous, four state Markov model (4SB), derived by Williams et al. ( 2013 ). Finally, a computational speed gain was observed with the proposed model in a regular spiking and sparse Pyramidal-Interneuron-Network-Gamma (sPING) network simulation with respect to the 4SB-model, due to the former having two differential equations less. Consequently, the proposed model allows for computationally efficient optogenetic neurostimulation and with the proposed fitting procedure will be valuable for further research in the field of optogenetics." @default.
• W3167555276 created "2021-06-22" @default.
• W3167555276 creator A5018341759 @default.
• W3167555276 creator A5019752497 @default.
• W3167555276 creator A5021159948 @default.
• W3167555276 creator A5021551548 @default.
• W3167555276 creator A5024310053 @default.
• W3167555276 creator A5058815082 @default.
• W3167555276 date "2021-06-16" @default.
• W3167555276 modified "2023-10-18" @default.
• W3167555276 title "Double Two-State Opsin Model With Autonomous Parameter Inference" @default.
• W3167555276 cites W1101348635 @default.
• W3167555276 cites W1965534758 @default.
• W3167555276 cites W1971766844 @default.
• W3167555276 cites W1975574255 @default.
• W3167555276 cites W1983972033 @default.
• W3167555276 cites W1997537106 @default.
• W3167555276 cites W2001406655 @default.
• W3167555276 cites W2017982457 @default.
• W3167555276 cites W2039347400 @default.
• W3167555276 cites W2042110107 @default.
• W3167555276 cites W2047627760 @default.
• W3167555276 cites W2056493740 @default.
• W3167555276 cites W2058082904 @default.
• W3167555276 cites W2058488568 @default.
• W3167555276 cites W2059485600 @default.
• W3167555276 cites W2062728762 @default.
• W3167555276 cites W2081752958 @default.
• W3167555276 cites W2102795260 @default.
• W3167555276 cites W2117453669 @default.
• W3167555276 cites W2129452432 @default.
• W3167555276 cites W2146831880 @default.
• W3167555276 cites W2159423248 @default.
• W3167555276 cites W2160961804 @default.
• W3167555276 cites W2163199750 @default.
• W3167555276 cites W2169600442 @default.
• W3167555276 cites W2175321621 @default.
• W3167555276 cites W2320438893 @default.
• W3167555276 cites W2732190457 @default.
• W3167555276 cites W2755627528 @default.
• W3167555276 cites W2769947821 @default.
• W3167555276 cites W2793359439 @default.
• W3167555276 cites W2905715657 @default.
• W3167555276 cites W2962702709 @default.
• W3167555276 doi "https://doi.org/10.3389/fncom.2021.688331" @default.
• W3167555276 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8243001" @default.
• W3167555276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34220478" @default.
• W3167555276 hasPublicationYear "2021" @default.
• W3167555276 type Work @default.
• W3167555276 sameAs 3167555276 @default.
• W3167555276 citedByCount "3" @default.
• W3167555276 countsByYear W31675552762023 @default.
• W3167555276 crossrefType "journal-article" @default.
• W3167555276 hasAuthorship W3167555276A5018341759 @default.
• W3167555276 hasAuthorship W3167555276A5019752497 @default.
• W3167555276 hasAuthorship W3167555276A5021159948 @default.
• W3167555276 hasAuthorship W3167555276A5021551548 @default.
• W3167555276 hasAuthorship W3167555276A5024310053 @default.
• W3167555276 hasAuthorship W3167555276A5058815082 @default.
• W3167555276 hasBestOaLocation W31675552761 @default.
• W3167555276 hasConcept C11413529 @default.
• W3167555276 hasConcept C119857082 @default.
• W3167555276 hasConcept C154945302 @default.
• W3167555276 hasConcept C169760540 @default.
• W3167555276 hasConcept C186060115 @default.
• W3167555276 hasConcept C202033177 @default.
• W3167555276 hasConcept C2776214188 @default.
• W3167555276 hasConcept C2780827179 @default.
• W3167555276 hasConcept C30028475 @default.
• W3167555276 hasConcept C41008148 @default.
• W3167555276 hasConcept C50738837 @default.
• W3167555276 hasConcept C55493867 @default.
• W3167555276 hasConcept C86803240 @default.
• W3167555276 hasConcept C98763669 @default.
• W3167555276 hasConceptScore W3167555276C11413529 @default.
• W3167555276 hasConceptScore W3167555276C119857082 @default.
• W3167555276 hasConceptScore W3167555276C154945302 @default.
• W3167555276 hasConceptScore W3167555276C169760540 @default.
• W3167555276 hasConceptScore W3167555276C186060115 @default.
• W3167555276 hasConceptScore W3167555276C202033177 @default.
• W3167555276 hasConceptScore W3167555276C2776214188 @default.
• W3167555276 hasConceptScore W3167555276C2780827179 @default.
• W3167555276 hasConceptScore W3167555276C30028475 @default.
• W3167555276 hasConceptScore W3167555276C41008148 @default.
• W3167555276 hasConceptScore W3167555276C50738837 @default.
• W3167555276 hasConceptScore W3167555276C55493867 @default.
• W3167555276 hasConceptScore W3167555276C86803240 @default.
• W3167555276 hasConceptScore W3167555276C98763669 @default.
• W3167555276 hasLocation W31675552761 @default.
• W3167555276 hasLocation W31675552762 @default.
• W3167555276 hasLocation W31675552763 @default.
• W3167555276 hasLocation W31675552764 @default.
• W3167555276 hasLocation W31675552765 @default.
• W3167555276 hasOpenAccess W3167555276 @default.
• W3167555276 hasPrimaryLocation W31675552761 @default.
• W3167555276 hasRelatedWork W1965534758 @default.
• W3167555276 hasRelatedWork W1981905570 @default.
• W3167555276 hasRelatedWork W2022228349 @default.
• W3167555276 hasRelatedWork W2166086184 @default.
• W3167555276 hasRelatedWork W2783624062 @default.

• next