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- W3167747496 endingPage "102604" @default.
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- W3167747496 abstract "This work aimed to develop, optimize, and evaluate the hypoglycemic activity of P. ligularis leaves extract (PLE) loaded self-emulsifying drug delivery system (SEDDS). The formulation components (oil, surfactant, and co-solvent) were selected based on the solubility studies. A Box-Behnken design (BBD) with 27 treatments was employed to find the optimal composition of PLE-SEDDS, analyzing the droplet size as the response variable. The polydispersity index (PDI) and zeta potential parameters were also measured. The pharmacological activity was evaluated through a glucose tolerance test. According to ANOVA for the droplet size variable, the linear model was highly significant (p < 0.001), and oil, surfactant, co-solvent, and silicone polymer (PDMSHEPMS) content and their interactions were statistically significant. The final composition of PLE-SEDDS was castor oil, Cremophor® EL, propylene glycol, PDMSHEPMS in proportions of 31: 120: 80: 30, respectively. The amount of P. ligularis extract incorporated in the formulation was 20%. The final formulation showed a 45.93 ± 1.02 nm droplet size with a PDI 0.27 ± 0.03 and zeta potential −10.92 ± 0.42 mV. Finally, in the in vivo glucose tolerance test, PLE-SEDDS improved hypoglycemic activity compared to the unformulated extract." @default.
- W3167747496 created "2021-06-22" @default.
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- W3167747496 date "2021-08-01" @default.
- W3167747496 modified "2023-10-14" @default.
- W3167747496 title "Development of a self-emulsifying drug delivery system (SEDDS) to improve the hypoglycemic activity of Passiflora ligularis leaves extract" @default.
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- W3167747496 doi "https://doi.org/10.1016/j.jddst.2021.102604" @default.
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