Matches in SemOpenAlex for { <https://semopenalex.org/work/W3167808045> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W3167808045 abstract "MMP-2 is expressed in almost all heart cells and is found in subcellular compartments including the nucleus. MMP-2 can be directly activated by oxidative stress (as peroxynitrite). Its activity is further regulated by its phosphorylation. To better study nuclear MMP-2 in the heart, we extracted the nuclear, cytosolic and membrane fractions from isolated rat hearts (briefly perfused to clear them of blood). Western Blots for lamin A/C (nucleus), GAPDH (cytosol) and VDAC/Porin (membrane) were used as specific markers to confirm fraction purity. Gelatin zymography of these fractions revealed MMP-2 but not MMP-9 activities and MMP-2 activity was about 15 times higher in the cytoplasm than in the nucleus. Interestingly, Western blot analysis showed that MMP-2 is present in similar amounts both in the nucleus and in the cytoplasm. In order to characterize possible regulators of MMP-2 activity, we analyzed for the presence of tissue inhibitors of metalloproteases (TIMPs). Western blots revealed that all forms of TIMPs (1–4) are found in the cytoplasm, TIMP-4 is also present in the membrane fraction, and no TIMP was detected in the nucleus. Our data suggest that myocardial MMP-2 activity in the nucleus is regulated by a mechanism different from inhibition by TIMPs, possibly by its phosphorylation. Funding: Canadian Institutes of Health Research." @default.
- W3167808045 created "2021-06-22" @default.
- W3167808045 creator A5018979908 @default.
- W3167808045 creator A5026696303 @default.
- W3167808045 creator A5062483057 @default.
- W3167808045 creator A5078744823 @default.
- W3167808045 date "2013-04-01" @default.
- W3167808045 modified "2023-09-23" @default.
- W3167808045 title "Nuclear MMP‐2: presence and activity in cardiac myocytes" @default.
- W3167808045 doi "https://doi.org/10.1096/fasebj.27.1_supplement.995.4" @default.
- W3167808045 hasPublicationYear "2013" @default.
- W3167808045 type Work @default.
- W3167808045 sameAs 3167808045 @default.
- W3167808045 citedByCount "0" @default.
- W3167808045 crossrefType "journal-article" @default.
- W3167808045 hasAuthorship W3167808045A5018979908 @default.
- W3167808045 hasAuthorship W3167808045A5026696303 @default.
- W3167808045 hasAuthorship W3167808045A5062483057 @default.
- W3167808045 hasAuthorship W3167808045A5078744823 @default.
- W3167808045 hasConcept C104317684 @default.
- W3167808045 hasConcept C105686024 @default.
- W3167808045 hasConcept C109523444 @default.
- W3167808045 hasConcept C11960822 @default.
- W3167808045 hasConcept C134792803 @default.
- W3167808045 hasConcept C150194340 @default.
- W3167808045 hasConcept C153911025 @default.
- W3167808045 hasConcept C179093185 @default.
- W3167808045 hasConcept C181199279 @default.
- W3167808045 hasConcept C185592680 @default.
- W3167808045 hasConcept C190062978 @default.
- W3167808045 hasConcept C2776415932 @default.
- W3167808045 hasConcept C2776879804 @default.
- W3167808045 hasConcept C2780114586 @default.
- W3167808045 hasConcept C2780723820 @default.
- W3167808045 hasConcept C28859421 @default.
- W3167808045 hasConcept C552990157 @default.
- W3167808045 hasConcept C55493867 @default.
- W3167808045 hasConcept C65871279 @default.
- W3167808045 hasConcept C83640560 @default.
- W3167808045 hasConcept C85265743 @default.
- W3167808045 hasConcept C86803240 @default.
- W3167808045 hasConcept C95444343 @default.
- W3167808045 hasConcept C98539663 @default.
- W3167808045 hasConceptScore W3167808045C104317684 @default.
- W3167808045 hasConceptScore W3167808045C105686024 @default.
- W3167808045 hasConceptScore W3167808045C109523444 @default.
- W3167808045 hasConceptScore W3167808045C11960822 @default.
- W3167808045 hasConceptScore W3167808045C134792803 @default.
- W3167808045 hasConceptScore W3167808045C150194340 @default.
- W3167808045 hasConceptScore W3167808045C153911025 @default.
- W3167808045 hasConceptScore W3167808045C179093185 @default.
- W3167808045 hasConceptScore W3167808045C181199279 @default.
- W3167808045 hasConceptScore W3167808045C185592680 @default.
- W3167808045 hasConceptScore W3167808045C190062978 @default.
- W3167808045 hasConceptScore W3167808045C2776415932 @default.
- W3167808045 hasConceptScore W3167808045C2776879804 @default.
- W3167808045 hasConceptScore W3167808045C2780114586 @default.
- W3167808045 hasConceptScore W3167808045C2780723820 @default.
- W3167808045 hasConceptScore W3167808045C28859421 @default.
- W3167808045 hasConceptScore W3167808045C552990157 @default.
- W3167808045 hasConceptScore W3167808045C55493867 @default.
- W3167808045 hasConceptScore W3167808045C65871279 @default.
- W3167808045 hasConceptScore W3167808045C83640560 @default.
- W3167808045 hasConceptScore W3167808045C85265743 @default.
- W3167808045 hasConceptScore W3167808045C86803240 @default.
- W3167808045 hasConceptScore W3167808045C95444343 @default.
- W3167808045 hasConceptScore W3167808045C98539663 @default.
- W3167808045 hasIssue "S1" @default.
- W3167808045 hasLocation W31678080451 @default.
- W3167808045 hasOpenAccess W3167808045 @default.
- W3167808045 hasPrimaryLocation W31678080451 @default.
- W3167808045 hasRelatedWork W1967804279 @default.
- W3167808045 hasRelatedWork W2150112961 @default.
- W3167808045 hasRelatedWork W2161063591 @default.
- W3167808045 hasRelatedWork W2348117125 @default.
- W3167808045 hasRelatedWork W2568733274 @default.
- W3167808045 hasRelatedWork W3048247788 @default.
- W3167808045 hasRelatedWork W3167808045 @default.
- W3167808045 hasRelatedWork W3205273114 @default.
- W3167808045 hasRelatedWork W655332150 @default.
- W3167808045 hasRelatedWork W952188103 @default.
- W3167808045 hasVolume "27" @default.
- W3167808045 isParatext "false" @default.
- W3167808045 isRetracted "false" @default.
- W3167808045 magId "3167808045" @default.
- W3167808045 workType "article" @default.